Page 513 - Concise Pathology for Exam Preparation ( PDFDrive )

498 SECTION II Diseases of Organ Systems

Gross Morphology
• Affected gland is enlarged; may weigh 300 gm or more.
• Cut surface shows multiple well-defined nodules that bulge from the surface.
• Two types of proliferation, glandular and stromal (fibromuscular), are seen.
• In nodules with primarily glandular proliferation, the cut surface is yellow-pink; consis-
tency is soft with milky-white fluid oozing out of it.
• In nodules with primarily stromal (fibromuscular) proliferation, surface is pale-grey,
tough without any fluid oozing out.
• True capsule is absent but plane of cleavage is present.

Microscopy (Fig. 17.3 A and B)

A

Fibromuscular
proliferation

B
FIGURE 17.3. (A) Section from NHP showing proliferation and cystic dilatation of glands
lined by two layers—inner layer of columnar cells and outer layer of cuboidal or flattened
epithelium. Multilayering and crowding of epithelium with formation of papillary infold-
ings is also seen (H&E; 1003). (B) Section from NHP showing stromal hyperplasia
(H&E; 1003).

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