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Chapter 61  Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults  980.e3


             77.  de Witte T, Brand R, van Biezen A, et al: Allogeneic stem cell trans-  93.  Koreth J, Pidala J, Perez WS, et al: Role of reduced-intensity condition-
                plantation for patients with refractory anaemia with matched related   ing allogeneic hematopoietic stem-cell transplantation in older patients
                and unrelated donors: delay of the transplant is associated with inferior   with de novo myelodysplastic syndromes: an international collaborative
                survival. Br J Haematol 146:627, 2009.                decision analysis. J Clin Oncol 31:2662, 2013.
             78.  Atallah E, Abrams J, Ayash L, et al: Long term follow-up of allogeneic   94.  Alessandrino  EP,  Porta  MG,  Malcovati  L,  et al:  Optimal  timing  of
                stem cell transplantation in patients with myelodysplastic syndromes   allogeneic  hematopoietic  stem  cell  transplantation  in  patients  with
                using  busulfan,  cytosine  arabinoside,  and  cyclophosphamide.  Am  J   myelodysplastic syndrome. Am J Hematol 88:581, 2013.
                Hematol 85:579, 2010.                              95.  Della Porta M, Alessandrino E, Jackson C, et al: Decision analysis of
             79.  Jurado M, Deeg HJ, Storer B, et al: Hematopoietic stem cell transplan-  allogeneic  stem  cell  transplantation  in  patients  with  myelodysplastic
                tation for advanced myelodysplastic syndrome after conditioning with   syndrome  stratified  according  to  the  revised  international  prognostic
                busulfan and fractionated total body irradiation is associated with low   scoring system (IPSS-R). Blood 124:531, 2014.
                relapse rate but considerable nonrelapse mortality. Biol Blood Marrow   96.  Malcovati L, Porta MG, Pascutto C, et al: Prognostic factors and life
                Transplant 8:161, 2002.                               expectancy in myelodysplastic syndromes classified according to who
             80.  Nakamura  R,  Rodriguez  R,  Palmer  J,  et al:  Reduced-intensity  con-  criteria:  a  basis  for  clinical  decision  making.  J  Clin  Oncol  23:7594,
                ditioning for allogeneic hematopoietic stem cell transplantation with   2005.
                fludarabine and melphalan is associated with durable disease control   97.  Alessandrino EP, Della Porta MG, Bacigalupo A, et al: WHO classifica-
                in  myelodysplastic  syndrome.  Bone  Marrow  Transplant  40:843,   tion and WPSS predict posttransplantation outcome in patients with
                2007.                                                 myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto
             81.  de Lima M, Couriel D, Thall PF, et al: Once-daily intravenous busulfan   di Midollo Osseo (GITMO). Blood 112:895, 2008.
                and fludarabine: clinical and pharmacokinetic results of a myeloabla-  98.  Bejar R, Levine R, Ebert BL: Unraveling the molecular pathophysiology
                tive,  reduced-toxicity  conditioning  regimen  for  allogeneic  stem  cell   of myelodysplastic syndromes. J Clin Oncol 29:504, 2011.
                transplantation in AML and MDS. Blood 104:857, 2004.  99.  Bejar R, Stevenson KE, Caughey B, et al: Somatic mutations predict
             82.  Alatrash G, de Lima M, Hamerschlak N, et al: Myeloablative reduced-  poor outcome in patients with myelodysplastic syndrome after hema-
                toxicity i.v. busulfan-fludarabine and allogeneic hematopoietic stem cell   topoietic stem-cell transplantation. J Clin Oncol 32:2691, 2014.
                transplant for patients with acute myeloid leukemia or myelodysplastic   100.  Della Porta MG, Malcovati L: Clinical relevance of extra-hematologic
                syndrome in the sixth through eighth decades of life. Biol Blood Marrow   comorbidity  in  the  management  of  patients  with  myelodysplastic
                Transplant 17:1490, 2011.                             syndrome. Haematologica 94:602, 2009.
             83.  Valcarcel  D,  Martino  R,  Caballero  D,  et al:  Sustained  remissions  of   101.  McClune  BL,  Weisdorf  DJ,  Pedersen  TL,  et al:  Effect  of  age  on
                high-risk acute myeloid leukemia and myelodysplastic syndrome after   outcome  of  reduced-intensity  hematopoietic  cell  transplantation
                reduced-intensity  conditioning  allogeneic  hematopoietic  transplanta-  for  older  patients  with  acute  myeloid  leukemia  in  first  complete
                tion: chronic graft-versus-host disease is the strongest factor improving   remission  or  with  myelodysplastic  syndrome.  J  Clin  Oncol  28:1878,
                survival. J Clin Oncol 26:577, 2008.                  2010.
             84.  Cho  BS,  Kim  YJ,  Cho  SG,  et al:  The  beneficial  effect  of  chronic   102.  Sorror ML, Maris MB, Storb R, et al: Hematopoietic cell transplanta-
                graft-versus-host  disease  on  the  clinical  outcome  of  transplantation   tion (HCT)-specific comorbidity index: a new tool for risk assessment
                with  fludarabine/busulfan-based  reduced-intensity  conditioning  for   before allogeneic HCT. Blood 106:2912, 2005.
                patients with de novo myelodysplastic syndrome. Int J Hematol 85:446,   103.  Sorror ML, Sandmaier BM, Storer BE, et al: Comorbidity and disease
                2007.                                                 status based risk stratification of outcomes among patients with acute
             85.  Kroger  N,  Bornhauser  M,  Ehninger  G,  et al:  Allogeneic  stem  cell   myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic
                transplantation  after  a  fludarabine/busulfan-based  reduced-intensity   cell transplantation. J Clin Oncol 25:4246, 2007.
                conditioning in patients with myelodysplastic syndrome or secondary   104.  Zipperer  E,  Pelz  D,  Nachtkamp  K,  et al:  The  hematopoietic  stem
                acute myeloid leukemia. Ann Hematol 82:336, 2003.     cell  transplantation  comorbidity  index  is  of  prognostic  relevance
             86.  Martino R, Valcarcel D, Brunet S, et al: Comparable non-relapse mor-  for  patients  with  myelodysplastic  syndrome.  Haematologica  94:729,
                tality and survival after hla-identical sibling blood stem cell transplanta-  2009.
                tion with reduced or conventional-intensity preparative regimens for   105.  Sorror ML, Storb RF, Sandmaier BM, et al: Comorbidity-age index:
                high-risk myelodysplasia or acute myeloid leukemia in first remission.   a clinical measure of biologic age before allogeneic hematopoietic cell
                Bone Marrow Transplant 41:33, 2008.                   transplantation. J Clin Oncol 32:3249, 2014.
             87.  Lim Z, Brand R, Martino R, et al: Allogeneic hematopoietic stem-cell   106.  Pullarkat V, Blanchard S, Tegtmeier B, et al: Iron overload adversely
                transplantation  for  patients  50  years  or  older  with  myelodysplastic   affects outcome of allogeneic hematopoietic cell transplantation. Bone
                syndromes or secondary acute myeloid leukemia. J Clin Oncol 28:405,   Marrow Transplant 42:799, 2008.
                2010.                                             107.  Warlick ED, Cioc A, Defor T, et al: Allogeneic stem cell transplantation
             88.  Kröger  N,  Brand  R,  Niederwieser  D,  et al:  Reduced  intensity  vs.   for adults with myelodysplastic syndromes: importance of pretransplant
                Standard conditioning followed by allogeneic stem cell transplantation   disease burden. Biol Blood Marrow Transplant 15:30, 2009.
                for patients with MDS or secondary AML: a prospective, randomized   108.  Nakai K, Kanda Y, Fukuhara S, et al: Value of chemotherapy before
                phase iii study of the chronic malignancies working party of the EBMT   allogeneic  hematopoietic  stem  cell  transplantation  from  an  HLA-
                (RICMAC-trial). Blood 124:320, 2014.                  identical sibling donor for myelodysplastic syndrome. Leukemia 19:396,
             89.  Nachtkamp  K,  Kundgen  A,  Strupp  C,  et al:  Impact  on  survival  of   2005.
                different treatments for myelodysplastic syndromes (MDS). Leuk Res   109.  Field  T,  Perkins  J,  Huang  Y,  et al:  5-Azacitidine  for  myelodysplasia
                33:1024, 2009.                                        before  allogeneic  hematopoietic  cell  transplantation.  Bone  Marrow
             90.  Cutler CS, Lee SJ, Greenberg P, et al: A decision analysis of allogeneic   Transplant 45:255, 2010.
                bone  marrow  transplantation  for  the  myelodysplastic  syndromes:   110.  Gerds  AT,  Gooley  TA,  Estey  EH,  et al:  Pretransplantation  therapy
                delayed transplantation for low-risk myelodysplasia is associated with   with  azacitidine  vs  induction  chemotherapy  and  posttransplantation
                improved outcome. Blood 104:579, 2004.                outcome in patients with MDS. Biol Blood Marrow Transplant 18:1211,
             91.  Lee JH, Lee JH, Lim SN, et al: Allogeneic hematopoietic cell trans-  2012.
                plantation  for  myelodysplastic  syndrome:  prognostic  significance  of   111.  Damaj G, Duhamel A, Robin M, et al: Impact of azacitidine before
                pre-transplant  IPSS  score  and  comorbidity.  Bone  Marrow Transplant   allogeneic stem-cell transplantation for myelodysplastic syndromes: a
                45:450, 2010.                                         study  by  the  Societe  Francaise  de  Greffe  de  Moelle  et  de Therapie-
             92.  Della  Porta  MG,  Alessandrino  EP,  Bacigalupo  A,  et al:  Predictive   Cellulaire  and  the  Groupe-Francophone  des  Myelodysplasies.  J  Clin
                factors for the outcome of allogeneic transplantation in patients with   Oncol 30:4533, 2012.
                MDS  stratified  according  to  the  revised  IPSS-R.  Blood  123:2333,   112.  Almstedt  M,  Blagitko-Dorfs  N,  Duque-Afonso  J,  et al:  The  DNA
                2014.                                                 demethylating  agent  5-aza-2’-deoxycytidine  induces  expression  of
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