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Chapter 107  Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies  1649


            Brunstein  C,  Barker  JN,  Weisdorf  DJ,  et al:  Umbilical  cord  blood  trans-  Liu  H,  Rich  ES,  Godley  L,  et al:  Reduced-intensity  conditioning  with
              plantation  after  non-myeloablative  conditioning:  impact  on  transplant   combined haploidentical and cord blood transplantation results in rapid
              outcomes  in  110  adults  with  hematological  disease.  Blood  110:3064,   engraftment, low GVHD, and durable remissions. Blood 118:6438, 2011.
              2007.                                               MacMillan ML, Weisdorf DJ, Brunstein CG, et al: Acute graft-versus-host
            Brunstein CG, Fuchs EJ, Carter SL, et al: Alternative donor transplantation:   disease  after  unrelated  donor  umbilical  cord  blood  transplantation:
              results  of  parallel  phase  II  trials  using  HLA-mismatched  related  bone   analysis of risk factors. Blood 113:2410, 2009.
              marrow or unrelated umbilical cord blood grafts. Blood 118:282, 2011.  Micklethwaite  KP,  Savoldo  B,  Hanley  PJ,  et al:  Derivation  of  human  T
            Brunstein CG, Gutman JA, Weisdorf DJ, et al: Allogeneic hematopoietic cell   lymphocytes  from  cord  blood  and  peripheral  blood  with  antiviral  and
              transplantation for hematological malignancy: relative risks and benefits   antileukemic specificity from a single culture as protection against infec-
              of double umbilical cord blood. Blood 116:4693, 2010.  tion and relapse after stem cell transplantation. Blood 115:2695, 2010.
            Christopherson  KW,  2nd,  Hangoc  G,  Mantel  CR,  et al:  Modulation  of   Ponce DM, Zheng J, Gonzales AM, et al: Reduced late mortality risk con-
              hematopoietic  stem  cell  homing  and  engraftment  by  CD26.  Science   tributes to similar survival after double-unit cord blood transplantation
              305:1000, 2004.                                       compared  with  related  and  unrelated  donor  hematopoietic  stem  cell
            Delaney C, Heimfeld S, Brashem-Stein C, et al: Notch-mediated expansion   transplantation. Biol Blood Marrow Transplant 17:1316, 2011.
              of human cord blood progenitor cells capable of rapid myeloid reconstitu-  Purtill D, Smith K, Devlin S, et al: Dominant unit CD34+ cell dose predicts
              tion. Nat Med 16:232, 2010.                           engraftment  after  double-unit  cord  blood  transplantation  and  is  influ-
            de Lima M, McNiece I, Robinson SN, et al: Cord-blood engraftment with   enced by bank practice. Blood 124(19):2905–2912, 2014.
              ex vivo mesenchymal-cell coculture. N Engl J Med 367(24):2305–2315,   Rocha V, Gluckman E: Improving outcomes of cord blood transplantation:
              2012.                                                 HLA  matching,  cell  dose  and  other  graft-  and  transplantation-related
            Eapen M, Klein JP, Sanz GF, et al: Effect of donor-recipient HLA matching   factors. Br J Haematol 147:262, 2009.
              at  HLA  A,  B,  C,  and  DRB1  on  outcomes  after  umbilical-cord  blood   Scaradavou  A,  Smith  KM,  Hawke  R,  et al:  Cord  blood  units  with  low
              transplantation for leukaemia and myelodysplastic syndrome: a retrospec-  CD34+ cell viability have a low probability of engraftment after double
              tive analysis. Lancet Oncol 11:653, 2010.             unit transplantation. Biol Blood Marrow Transplant 16:500, 2010.
            Eapen M, Rocha V, Sanz G, et al: Effect of graft source on unrelated donor   Stevens CE, Carrier C, Carpenter C, et al: HLA mismatch direction in cord
              haemopoietic stem-cell transplantation in adults with acute leukaemia: a   blood  transplantation:  impact  on  outcome  and  implications  for  cord
              retrospective analysis. Lancet Oncol 11:653, 2010.    blood unit selection. Blood 118:3969, 2011.
            Eapen  M,  Rubinstein  P,  Zhang  MJ,  et al:  Comparison  of  outcomes  after   van  Rood  JJ,  Stevens  CE,  Smits  J,  et al:  Reexposure  of  cord  blood  to
              transplantation  of  unrelated  donor  umbilical  cord  blood  and  bone   non-inherited maternal HLA antigens improves transplant outcome in
              marrow in children with acute leukemia. Lancet 369:1947, 2007.  hematological malignancies. Proc Natl Acad Sci USA 106:19952, 2009.
            Eldjerou LK, Chaudhury S, Baisre-de Leon A, et al: An in vivo model of   Verneris MR, Brunstein CG, Barker J, et al: Relapse risk after umbilical cord
              double  unit  cord  blood  transplantation  that  correlates  with  clinical   blood transplantation: enhanced graft-versus-leukemia effect in recipients
              engraftment. Blood 116:3999, 2010.                    of 2 units. Blood 114:4293, 2009.
            Gutman  JA,  Turtle  CJ,  Manley  TJ,  et al:  Single-unit  dominance  after     Wagner JE, Barker JN, DeFor TE, et al: Transplantation of unrelated donor
              double-unit umbilical cord blood transplantation coincides with a specific   umbilical cord blood in 102 patients with malignant and nonmalignant
              CD8+  T-cell  response  against  the  nonengrafted  unit.  Blood  115:757,   diseases: influence of CD34 cell dose and HLA disparity on treatment-
              2010.                                                 related mortality and survival. Blood 100:1611, 2002.
            Hanley PJ, Cruz CR, Savoldo B, et al: Functionally active virus-specific T   Wagner JE, Jr, Eapen M, Carter S, et al: One-unit versus two-unit cord-blood
              cells that target CMV, adenovirus, and EBV can be expanded from naive   transplantation for hematologic cancers. N Engl J Med 371(18):1685–
              T-cell populations in cord blood and will target a range of viral epitopes.   1694, 2014.
              Blood 114:2009, 1958.
            Kurtzberg J, Prasad VK, Carter SL, et al: Results of the Cord Blood Trans-
              plantation Study (COBLT): clinical outcomes of unrelated donor umbili-  REFERENCES
              cal  cord  blood  transplantation  in  pediatric  patients  with  hematologic
              malignancies. Blood 112:4318, 2008.                 For the complete list of references, log on to www.expertconsult.com.
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