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Chapter 107 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies 1649
Brunstein C, Barker JN, Weisdorf DJ, et al: Umbilical cord blood trans- Liu H, Rich ES, Godley L, et al: Reduced-intensity conditioning with
plantation after non-myeloablative conditioning: impact on transplant combined haploidentical and cord blood transplantation results in rapid
outcomes in 110 adults with hematological disease. Blood 110:3064, engraftment, low GVHD, and durable remissions. Blood 118:6438, 2011.
2007. MacMillan ML, Weisdorf DJ, Brunstein CG, et al: Acute graft-versus-host
Brunstein CG, Fuchs EJ, Carter SL, et al: Alternative donor transplantation: disease after unrelated donor umbilical cord blood transplantation:
results of parallel phase II trials using HLA-mismatched related bone analysis of risk factors. Blood 113:2410, 2009.
marrow or unrelated umbilical cord blood grafts. Blood 118:282, 2011. Micklethwaite KP, Savoldo B, Hanley PJ, et al: Derivation of human T
Brunstein CG, Gutman JA, Weisdorf DJ, et al: Allogeneic hematopoietic cell lymphocytes from cord blood and peripheral blood with antiviral and
transplantation for hematological malignancy: relative risks and benefits antileukemic specificity from a single culture as protection against infec-
of double umbilical cord blood. Blood 116:4693, 2010. tion and relapse after stem cell transplantation. Blood 115:2695, 2010.
Christopherson KW, 2nd, Hangoc G, Mantel CR, et al: Modulation of Ponce DM, Zheng J, Gonzales AM, et al: Reduced late mortality risk con-
hematopoietic stem cell homing and engraftment by CD26. Science tributes to similar survival after double-unit cord blood transplantation
305:1000, 2004. compared with related and unrelated donor hematopoietic stem cell
Delaney C, Heimfeld S, Brashem-Stein C, et al: Notch-mediated expansion transplantation. Biol Blood Marrow Transplant 17:1316, 2011.
of human cord blood progenitor cells capable of rapid myeloid reconstitu- Purtill D, Smith K, Devlin S, et al: Dominant unit CD34+ cell dose predicts
tion. Nat Med 16:232, 2010. engraftment after double-unit cord blood transplantation and is influ-
de Lima M, McNiece I, Robinson SN, et al: Cord-blood engraftment with enced by bank practice. Blood 124(19):2905–2912, 2014.
ex vivo mesenchymal-cell coculture. N Engl J Med 367(24):2305–2315, Rocha V, Gluckman E: Improving outcomes of cord blood transplantation:
2012. HLA matching, cell dose and other graft- and transplantation-related
Eapen M, Klein JP, Sanz GF, et al: Effect of donor-recipient HLA matching factors. Br J Haematol 147:262, 2009.
at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood Scaradavou A, Smith KM, Hawke R, et al: Cord blood units with low
transplantation for leukaemia and myelodysplastic syndrome: a retrospec- CD34+ cell viability have a low probability of engraftment after double
tive analysis. Lancet Oncol 11:653, 2010. unit transplantation. Biol Blood Marrow Transplant 16:500, 2010.
Eapen M, Rocha V, Sanz G, et al: Effect of graft source on unrelated donor Stevens CE, Carrier C, Carpenter C, et al: HLA mismatch direction in cord
haemopoietic stem-cell transplantation in adults with acute leukaemia: a blood transplantation: impact on outcome and implications for cord
retrospective analysis. Lancet Oncol 11:653, 2010. blood unit selection. Blood 118:3969, 2011.
Eapen M, Rubinstein P, Zhang MJ, et al: Comparison of outcomes after van Rood JJ, Stevens CE, Smits J, et al: Reexposure of cord blood to
transplantation of unrelated donor umbilical cord blood and bone non-inherited maternal HLA antigens improves transplant outcome in
marrow in children with acute leukemia. Lancet 369:1947, 2007. hematological malignancies. Proc Natl Acad Sci USA 106:19952, 2009.
Eldjerou LK, Chaudhury S, Baisre-de Leon A, et al: An in vivo model of Verneris MR, Brunstein CG, Barker J, et al: Relapse risk after umbilical cord
double unit cord blood transplantation that correlates with clinical blood transplantation: enhanced graft-versus-leukemia effect in recipients
engraftment. Blood 116:3999, 2010. of 2 units. Blood 114:4293, 2009.
Gutman JA, Turtle CJ, Manley TJ, et al: Single-unit dominance after Wagner JE, Barker JN, DeFor TE, et al: Transplantation of unrelated donor
double-unit umbilical cord blood transplantation coincides with a specific umbilical cord blood in 102 patients with malignant and nonmalignant
CD8+ T-cell response against the nonengrafted unit. Blood 115:757, diseases: influence of CD34 cell dose and HLA disparity on treatment-
2010. related mortality and survival. Blood 100:1611, 2002.
Hanley PJ, Cruz CR, Savoldo B, et al: Functionally active virus-specific T Wagner JE, Jr, Eapen M, Carter S, et al: One-unit versus two-unit cord-blood
cells that target CMV, adenovirus, and EBV can be expanded from naive transplantation for hematologic cancers. N Engl J Med 371(18):1685–
T-cell populations in cord blood and will target a range of viral epitopes. 1694, 2014.
Blood 114:2009, 1958.
Kurtzberg J, Prasad VK, Carter SL, et al: Results of the Cord Blood Trans-
plantation Study (COBLT): clinical outcomes of unrelated donor umbili- REFERENCES
cal cord blood transplantation in pediatric patients with hematologic
malignancies. Blood 112:4318, 2008. For the complete list of references, log on to www.expertconsult.com.

