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1649.e4 Part X Transplantation
(UCBT) Accelerates Engraftment and Improves 100 Day Survival In microvessels but not homing to bone marrow. Blood 105(2):567–575,
Myeloablated Patients Compared To a Registry Cohort Undergoing 2005.
Double Unit UCBT: Results Of a Multicenter Study Of 101 Patients 133. Robinson SN, Simmons PJ, Thomas MW, et al: Ex vivo fucosyl-
With Hematologic Malignancies. Blood 122(21):2013. ation improves human cord blood engraftment in NOD-SCID
117. de Lima M, McNiece I, Robinson SN, et al: Cord-blood engraftment IL-2Rgamma(null) mice. Exp Hematol 40(6):445–456, 2012.
with ex vivo mesenchymal-cell coculture. N Engl J Med 367(24):2305– 134. Somers JA, Brand A, van Hensbergen Y, et al: Double umbilical cord
2315, 2012. blood transplantation: a study of early engraftment kinetics in leukocyte
118. Horwitz ME, Chao NJ, Rizzieri DA, et al: Umbilical cord blood expan- subsets using HLA-specific monoclonal antibodies. Biol Blood Marrow
sion with nicotinamide provides long-term multilineage engraftment. Transplant 19(2):266–273, 2013.
J Clin Invest 124(7):3121–3128, 2014. 135. Ruggeri A, Peffault de Latour R, Carmagnat M, et al: Outcomes, infec-
119. Wagner JE, Brunstein C, McKenna D, et al: StemRegenin-1 (SR1) tions, and immune reconstitution after double cord blood transplanta-
Expansion Culture Abrogates the Engraftment Barrier Associated with tion in patients with high-risk hematological diseases. Transpl Infect Dis
Umbilical Cord Blood Transplantation (UCBT) 56th American Society of 13(5):456–465, 2011.
Hematology Annual Meeting; 2014; San Francisco, CA. 136. Saliba RM, Rezvani K, Leen A, et al: General and Virus-Specific
120. Campbell TB, Hangoc G, Liu Y, et al: Inhibition of CD26 in human Immune Cell Reconstitution Following Double Cord Blood Trans-
cord blood CD34+ cells enhances their engraftment of nonobese plantation. Biol Blood Marrow Transplant 2015.
diabetic/severe combined immunodeficiency mice. Stem Cells Dev 137. Hanley PJ, Cruz CR, Shpall EJ, et al: Improving clinical outcomes
16(3):347–354, 2007. using adoptively transferred immune cells from umbilical cord blood.
121. Christopherson KW, 2nd, Hangoc G, Mantel CR, et al: Modulation Cytotherapy 12(6):713–720, 2010.
of hematopoietic stem cell homing and engraftment by CD26. Science 138. Sun Q, Burton RL, Pollok KE, et al: CD4(+) Epstein-Barr virus-
305(5686):1000–1003, 2004. specific cytotoxic T-lymphocytes from human umbilical cord blood.
122. Christopherson KW, 2nd, Paganessi LA, Napier S, et al: CD26 Cell Immunol 195(2):81–88, 1999.
inhibition on CD34+ or lineage- human umbilical cord blood donor 139. Park KD, Marti L, Kurtzberg J, et al: In vitro priming and expansion
hematopoietic stem cells/hematopoietic progenitor cells improves long- of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood
term engraftment into NOD/SCID/Beta2null immunodeficient mice. lymphocytes. Blood 108(5):1770–1773, 2006.
Stem Cells Dev 16(3):355–360, 2007. 140. Barker JN, Doubrovina E, Sauter C, et al: Successful treatment of
123. Cutler C, Multani P, Robbins D, et al: Prostaglandin-modulated EBV-associated posttransplantation lymphoma after cord blood trans-
umbilical cord blood hematopoietic stem cell transplantation. Blood plantation using third-party EBV-specific cytotoxic T lymphocytes.
122(17):3074–3081, 2013. Blood 116(23):5045–5049, 2010.
124. Popat U, Mehta RS, Rezvani K, et al: Enforced fucosylation of cord 141. Hanley PJ, Cruz CR, Savoldo B, et al: Functionally active virus-specific
blood hematopoietic cells accelerates neutrophil and platelet engraft- T cells that target CMV, adenovirus, and EBV can be expanded from
ment after transplantation. Blood Mar 16 2015. naive T-cell populations in cord blood and will target a range of viral
125. Fernandez MN, Regidor C, Cabrera R, et al: Unrelated umbilical cord epitopes. Blood 114(9):1958–1967, 2009.
blood transplants in adults: Early recovery of neutrophils by support- 142. Leen AM, Myers GD, Sili U, et al: Monoculture-derived T lymphocytes
ive co-transplantation of a low number of highly purified peripheral specific for multiple viruses expand and produce clinically relevant effects
blood CD34+ cells from an HLA-haploidentical donor. Exp Hematol in immunocompromised individuals. Nat Med 12(10):1160–1166,
31(6):535–544, 2003. 2006.
126. Sanchez ME, Ponce DM, Lauer Emily, et al: Double-unit cord blood 143. Hanley P, Leen A, Gee AP, et al: Multi-Virus-Specific T-Cell Therapy
(CB) transplantation (DCBT) combined with haplo-identical peripheral For Patients After Hematopoietic Stem Cell and Cord Blood Transplan-
blood CD34+ cells (HaploCD34+) is associated with enhanced neutro- tation. Blood 122(21):2013.
phil recovery, universal haplo rejection, and frequent pre-engraftment 144. Micklethwaite KP, Savoldo B, Hanley PJ, et al: Derivation of human
syndrome. Biol Blood Marrow Transplant 21(2):S43–S44, 2015. T lymphocytes from cord blood and peripheral blood with antivi-
127. Peled T, Landau E, Mandel J, et al: Linear polyamine copper chelator ral and antileukemic specificity from a single culture as protection
tetraethylenepentamine augments long-term ex vivo expansion of cord against infection and relapse after stem cell transplantation. Blood
blood-derived CD34+ cells and increases their engraftment potential 115(13):2695–2703, 2010.
in NOD/SCID mice. Exp Hematol 32(6):547–555, 2004. 145. Xing D, Ramsay AG, Gribben JG, et al: Cord blood natural killer cells
128. Peled T, Mandel J, Goudsmid RN, et al: Pre-clinical development of exhibit impaired lytic immunological synapse formation that is reversed
cord blood-derived progenitor cell graft expanded ex vivo with cytokines with IL-2 ex vivo expansion. J Immunother 33(7):684–696, 2010.
and the polyamine copper chelator tetraethylenepentamine. Cytotherapy 146. Weber G, Gerdemann U, Caruana I, et al: Generation of multi-
6(4):344–355, 2004. leukemia antigen-specific T cells to enhance the graft-versus-leukemia
129. Boitano AE, Wang J, Romeo R, et al: Aryl hydrocarbon receptor effect after allogeneic stem cell transplant. Leukemia 27(7):1538–1547,
antagonists promote the expansion of human hematopoietic stem cells. 2013.
Science 329(5997):1345–1348, 2010. 147. Shah N, Martin-Antonio B, Yang H, et al: Antigen presenting cell-
130. Himburg HA, Muramoto GG, Daher P, et al: Pleiotrophin regulates mediated expansion of human umbilical cord blood yields log-scale
the expansion and regeneration of hematopoietic stem cells. Nat Med expansion of natural killer cells with anti-myeloma activity. PLoS ONE
16(4):475–482, 2010. 8(10):e76781, 2013.
131. Zhang CC, Kaba M, Iizuka S, et al: Angiopoietin-like 5 and IGFBP2 148. Parmar S, Liu X, Najjar A, et al: Ex vivo fucosylation of third-party
stimulate ex vivo expansion of human cord blood hematopoietic stem human regulatory T cells enhances anti-graft-versus-host disease
cells as assayed by NOD/SCID transplantation. Blood 111(7):3415– potency in vivo. Blood 125(9):1502–1506, 2015.
3423, 2008.
132. Hidalgo A, Frenette PS: Enforced fucosylation of neonatal CD34+
cells generates selectin ligands that enhance the initial interactions with

