Page 2144 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 126 Molecular Basis of Blood Coagulation 1905

Lu D, Kalafatis M, Mann KG, et al: Comparison of activated protein C/ Stafford DW: The vitamin K cycle. J Thromb Haemost 3:1873–1878, 2005.
protein S–mediated inactivation of human factor VIII and factor V. Blood Stenflo J, Ferlund P, Egan W, et al: Vitamin K dependent modifications
87:4708–4717, 1996. of glutamic acid residues in prothrombin. Proc Natl Acad Sci USA
Mann KG, Jenny RJ, Krishnaswamy S: Cofactor proteins in the assembly 71:2730–2733, 1974.
and expression of blood clotting enzyme complexes. Annu Rev Biochem van’t Veer C, Mann KG: Regulation of tissue factor initiated thrombin gen-
57:915–956, 1988. eration by the stoichiometric inhibitors tissue factor pathway inhibitor,
Mann KG, Kalafatis M: Factor V: a combination of Dr Jekyll and Mr Hyde. antithrombin-III, and heparin cofactor-II. J Biol Chem 272:4367–4377,
Blood 101:20–30, 2003. 1997.
Mann KG, Nesheim ME, Church WR, et al: Surface-dependent reactions Weiler-Guettler H, Christie PD, Beeler DL, et al: A targeted point mutation
of the vitamin K–dependent enzyme complexes. Blood 76:1–16, 1990. in thrombomodulin generates viable mice with a prethrombotic state. J
Parker KA, Tollefsen DM: The protease specificity of heparin cofactor Clin Invest 101:1983–1991, 1998.
II. Inhibition of thrombin generated during coagulation. J Biol Chem
260:3501–3505, 1985.
Patthy L: Evolution of the proteases of blood coagulation and fibrinolysis by REFERENCES
assembly from modules. Cell 41:657–663, 1985.
Pittman DD, Tomkinson KN, Kaufman RJ: Post-translational requirements For the complete list of references, log on to www.expertconsult.com.
for functional factor V and factor VIII secretion in mammalian cells. J
Biol Chem 269:17329–17337, 1994.
Saenko EL, Scandella D: The acidic region of the factor VIII light chain
and the C2 domain together form the high affinity binding site for von
Willebrand factor. J Biol Chem 272:18007–18014, 1997.