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280 Part III Immunologic Basis of Hematology

TABLE Monoclonal Antibodies Approved by the FDA as Therapies
24.4
Year Route of
Generic Name Trade Name Target Source Approved Indication Administration
Muromonab-CD3 Orthoclone CD3 Murine 1986 Transplant rejection Intravenous
Rituximab Rituxan CD20 Chimeric 1994 Lymphoma, CLL, Intravenous
microscopic polyarteritis
nodosa, Wegener,
rheumatoid arthritis
Abciximab ReoPro GPIIb/IIIa Chimeric Fab 1994 Angioplasty Intravenous
Daclizumab Zenapax CD25 Humanized 1997 Transplant rejection (no Intravenous
longer available)
Trastuzumab Herceptin HER-2 Humanized 1998 Breast cancer, gastric and Intravenous
GE junction tumors
Palivizumab Synagis RSV Humanized 1998 RSV prophylaxis Intramuscular
Basiliximab Simulect CD25 Chimeric 1998 Transplant rejection Intravenous
Infliximab Remicade TNF-α Chimeric 1998 Crohn disease, ankylosing Intravenous
spondylitis, plaque
psoriasis, psoriatic
arthritis, rheumatoid
arthritis, ulcerative
colitis
Gemtuzumab Mylotarg CD33 Humanized 2000 AML (no longer available) Intravenous
ozogamicin
Alemtuzumab Campath/ CD52 Humanized 2001 CLL, T-cell lymphoma, Intravenous or
Lemtrada multiple sclerosis subcutaneous
Adalimumab Humira TNF-α Human 2002 Rheumatoid arthritis, Subcutaneous
psoriatic arthritis, Crohn
disease
Ibritumomab Zevalin CD20 Mouse radioconjugate 2002 Lymphoma Intravenous
tiuxetan
Omalizumab Xolair IgE Humanized 2003 Severe (allergic) asthma, Subcutaneous
idiopathic urticaria
Tositumomab-I131 Bexxar CD20 Mouse radioconjugate 2003 Lymphoma (no longer Intravenous
available)
Cetuximab Erbitux EGFR Chimeric 2004 Colon cancer, head and Intravenous
neck cancer,
Natalizumab Tysabri α4β1 Humanized 2004 Multiple sclerosis, Crohn Intravenous
disease
Bevacizumab Avastin VEGF Humanized 2004 Colon, renal, cervical, Intravenous
ovarian, and lung cancer
Ranibizumab Lucentis VEGF Humanized Fab 2006 Wet AMD, diabetic macular Intravitreal
edema, macular edema
following retinal vein
occlusion
Panitumumab Vectibix EGFR Human 2006 Colorectal cancer Intravenous
Eculizumab Soliris C5 Humanized 2007 PNH, aHUS Intravenous
Certolizumab pegol Cimzia TNF-α Humanized Fab 2008 Crohn disease, psoriatic Subcutaneous
arthritis
Canakinumab Ilaris IL-1b Human 2009 Cryopyrin-associated Subcutaneous
periodic syndromes,
familial cold urticaria,
systemic onset juvenile
chronic arthritis,
Muckle-Wells syndrome
Golimumab Simponi TNF Human 2009 Rheumatoid and psoriatic Subcutaneous
arthritis, ankylosing
spondylitis