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1186           Part IX:  Lymphocytes and Plasma Cells                                                                                              Chapter 76:  Functions of T Lymphocytes: T-cell Receptors for Antigen         1187




               in the redistribution of TCRs, costimulation, and accessory molecules     24.  Macian F: NFAT proteins: Key regulators of T-cell development and function. Nat Rev
               into the region beneath the T-cell:APC contact site.  These molecules   Immunol 5:472–484, 2005.
                                                     128
               are segregated into central (cSMAC), peripheral (pSMAC) and distal     25.  Devine L, Kieffer LJ, Aitken V, Kavathas PB: Human CD8β, but not mouse CD8β, can
                                                                         be expressed in the absence of CD8α as a ββ homodimer. J Immunol 164:833–838, 2000.
               (dSMAC) supramolecular activation clusters (SMACs). The cSMAC     26.  Zhu C, Jiang N, Huang J, et al: Insights from in situ analysis of TCR–pMHC recogni-
               contains a concentration of TCR:CD3:peptide:MHC complexes,   tion: Response of an interaction network. Immunol Rev 251:49–64, 2013.
               costimulatory molecules such as CD28, and signaling molecules such     27.  Gao GF, Rao Z, Bell JI: Molecular coordination of αβ T-cell receptors and corecep-
                                                                         tors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends Immunol 23:
               as PKCθ, while the pSMAC is enriched with adhesion molecules such   408–413, 2002.
                                                               129
               as LFA-1. The dSMAC contains large glycoproteins such as CD45.  In     28.  Reith W, Mach B: The bare lymphocyte syndrome and the regulation of MHC expres-
               addition to priming of T-cell responses, the immunological synapse is   sion. Annu Rev Immunol 19:331–373, 2001.
               also important for effector functions.  For example, the pSMAC has     29.  Artyomov MN, Lis M, Devadas S, et al: CD4 and CD8 binding to MHC molecules pri-
                                           130
                                                                         marily acts to enhance Lck delivery. Proc Natl Acad Sci U S A 107:16916–16921, 2010.
               been suggested to polarize cytotoxic granules released by cytotoxic CD8     30.  Ashorn PA, Berger EA, Moss B: Human immunodeficiency virus envelope glycopro-
               T cells toward the target cells, therefore preventing the leakage of cyto-  tein/CD4-mediated fusion of nonprimate cells with human cells. J Virol 64:2149–2156,
                                                                         1990.
               lytic granule contents to bystander cells, and the cSMAC is implicated     31.  Moir S, Chun T-W, Fauci AS: Pathogenic mechanisms of HIV disease. Annu Rev Pathol
               as a site for receptor internalization and degradation.   6:223–248, 2011.
                                                                        32.  Schols D: HIV co-receptors as targets for antiviral therapy. Curr Top Med Chem 4:
                                                                         883–893, 2004.
                                                                        33.  Singer A, Adoro S, Park J-H: Lineage fate and intense debate: Myths, models and mech-
               REFERENCES                                                anisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 8:788–801, 2008.
                                                                        34.  Kidd P: Th1/Th2 balance: The hypothesis, its limitations, and implications for health
                 1.  Garcia KC, Teyton L, Wilson IA: Structural basis of T cell recognition. Annu Rev Immunol   and disease. Altern Med Rev 8:223–246, 2003.
                  17:369–397, 1999.                                     35.  Annunziato F, Cosmi L, Galli G, et al: Assessment of chemokine receptor expression by
                 2.  O’Brien RL, Born WK: γδ T cell subsets: A link between TCR and function? Semin   human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol 65:691–699, 1999.
                  Immunol 22:193–198, 2010.                             36.  Annunziato F, Galli G, Cosmi L, et al: Molecules associated with human Th1 or Th2
                 3.  Chodaczek G, Papanna V, Zal MA, Zal T: Body-barrier surveillance by epidermal γδ   cells. Eur Cytokine Netw 9:12–16, 1998.
                  TCRs. Nat Immunol 13:272–282, 2012.                   37.  Bachelerie F, Ben-Baruch A, Burkhardt AM, et al: International Union of Pharmacol-
                 4.  Krangel MS: Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol   ogy. LXXXIX. Update on the extended family of chemokine receptors and introducing
                  21:133–139, 2009.                                      a new nomenclature for atypical chemokine receptors. Pharmacol Rev 66:1–79, 2014.
                 5.  Langerak AW, Groenen PJTA, Bruggemann M, et al: EuroClonality/BIOMED-2 guide-    38.  Zhu J, Paul WE: Peripheral CD4+ T-cell differentiation regulated by networks of cytok-
                  lines for interpretation and reporting of Ig/TCR clonality testing in suspected lymph-  ines and transcription factors. Immunol Rev 238:247–262, 2010.
                  oproliferations. Leukemia 26:2159–2171, 2012.         39.  Oestreich KJ, Weinmann AS: Transcriptional mechanisms that regulate T helper 1 cell
                 6.  van der Velden VHJ, Cazzaniga G, Schrauder A, et al: Analysis of minimal residual   differentiation. Curr Opin Immunol 24:191–195, 2012.
                  disease by Ig//TCR gene rearrangements: Guidelines for interpretation of real-time     40.  Yagi R, Zhu J, Paul WE: An updated view on transcription factor GATA3-mediated
                  quantitative PCR data. Leukemia 21:604–611, 2007.      regulation of Th1 and Th2 cell differentiation. Int Immunol 23:415–420, 2011.
                 7.  Schrappe M, Valsecchi MG, Bartram CR, et al: Late MRD response determines relapse     41.  Maggi E: The TH1/TH2 paradigm in allergy. Immunotechnology 3:233–244, 1998.
                  risk overall and in subsets of childhood T-cell ALL: Results of the AIEOP-BFM-ALL     42.  Allen JE, Sutherland TE: Host protective roles of type 2 immunity: Parasite killing and
                  2000 study. Blood 118:2077–2084, 2011.                 tissue repair, flip sides of the same coin. Semin Immunol 26:329–340, 2014.
                 8.  Zinkernagel RM, Doherty PC: Immunological surveillance against altered self com-    43.  Schramm G, Haas H: Th2 immune response against Schistosoma mansoni infection.
                  ponents by sensitised T lymphocytes in lymphocytic choriomeningitis.  Nature 251:   Microbes Infect 12:881–888, 2010.
                  547–548, 1974.                                        44.  Singh RP: Immunoregulation of cytokines in infectious diseases (leprosy), future strat-
                 9.  Zinkernagel RM, Doherty PC: Restriction of in vitro T cell-mediated cytotoxicity in   egies. Nihon Hansenbyo Gakkai Zasshi 67:263–268, 1998.
                  lymphocytic  choriomeningitis  within  a  syngeneic  or  semiallogeneic  system.  Nature     45.  Lienhardt C, Azzurri A, Amedei A, et al: Active tuberculosis in Africa is associated with
                  248:701–702, 1974.                                     reduced Th1 and increased Th2 activity in vivo. Eur J Immunol 32:1605–1613, 2002.
                 10.  Garcia KC, Degano M, Stanfield RL, et al: An alphabeta T cell receptor structure at 2.5     46.  Galindo CL, Rosenzweig JA, Kirtley ML, Chopra AK: Pathogenesis of Y. enterocolitica
                  A and its orientation in the TCR-MHC complex. Science 274:209–219, 1996.  and Y. pseudotuberculosis in human yersiniosis. J Pathog 2011:16, 2011.
                 11.  Baker BM, Scott DR, Blevins SJ, Hawse WF: Structural and dynamic control of T-cell     47.  Steere AC, Drouin EE, Glickstein LJ: Relationship between Immunity to Borrelia burg-
                  receptor specificity, cross-reactivity, and binding mechanism. Immunol Rev 250:10–31,   dorferi outer-surface protein A (OspA) and Lyme arthritis. Clin Infect Dis 52:s259–s265,
                  2012.                                                  2011.
                 12.  Wang J-H, Reinherz EL: The structural basis of αβ T-lineage immune recognition: TCR     48.  D’Elios MM, Amedei A, Benagiano M, et al: Helicobacter pylori, T cells and cytokines:
                  docking topologies, mechanotransduction, and co-receptor function.  Immunol Rev   The “dangerous liaisons.” FEMS Immunol Med Microbiol 44:113–119, 2005.
                  250:102–119, 2012.                                    49.  Vignali DA, Collison LW, Workman CJ: How regulatory T cells work. Nat Rev Immunol
                 13.  Lever M, Maini PK, van der Merwe PA, Dushek O: Phenotypic models of T cell activa-  8:523–532, 2008.
                  tion. Nat Rev Immunol 14:619–629, 2014.               50.  Sakaguchi S, Yamaguchi T, Nomura T, Ono M: Regulatory T cells and immune toler-
                 14.  Barral DC, Brenner MB: CD1 antigen presentation: How it works. Nat Rev Immunol   ance. Cell 133:775–787, 2008.
                  7:929–941, 2007.                                      51.  Rudensky AY: Regulatory T cells and Foxp3. Immunol Rev 241:260–268, 2011.
                 15.  Cohen NR, Garg S, Brenner MB: Antigen presentation by CD1: Lipids, T Cells, and     52.  Fu W, Ergun A, Lu T, et al: A multiply redundant genetic switch “locks in” the transcrip-
                  NKT cells in microbial immunity, in Advances in Immunology, edited by Frederick WA,   tional signature of regulatory T cells. Nat Immunol 13:972–980, 2012.
                  pp 1–94.: Academic Press, 102:1–94, 2009.             53.  d’Hennezel E, Bin Dhuban K, Torgerson T, Piccirillo C: The immunogenetics of
                 16.  Ferreira LM: Gammadelta T cells: Innately adaptive immune cells? Int Rev Immunol   immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.
                  32:223–248, 2013.                                      J Med Genet 49:291–302, 2012.
                 17.  Godfrey DI, Rossjohn J, McCluskey J: The fidelity, occasional promiscuity, and versatil-    54.  Aaltonen J, Bjorses P, Perheentupa J, et al: An autoimmune disease, APECED, caused
                  ity of T cell receptor recognition. Immunity 28:304–314, 2008.  by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet
                 18.  Norell H, Moretta A, Silva-Santos B, Moretta L: At the bench: Preclinical rationale for   17:399–403, 1997.
                  exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias.      55.  Capalbo D, Giardino G, Martino LD, et al: Genetic basis of altered central tolerance and
                  J Leukoc Biol 94:1123–1139, 2013.                      autoimmune diseases: A lesson from AIRE mutations. Int Rev Immunol 31:344–362,
                 19.  Bonneville M, O’Brien RL, Born WK: γδ T cell effector functions: A blend of innate   2012.
                  programming and acquired plasticity. Nat Rev Immunol 10:467–478, 2010.    56.  Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY: A function for interleukin 2 in
                 20.  Wucherpfennig KW, Gagnon E, Call MJ, et al: Structural biology of the T-cell receptor:   Foxp3-expressing regulatory T cells. Nat Immunol 6:1142–1151, 2005.
                  Insights into receptor assembly, ligand recognition, and initiation of signaling. Cold     57.  Ohkura N, Hamaguchi M, Morikawa H, et al: T cell receptor stimulation-induced
                  Spring Harb Perspect Biol 2:a005140, 2010.             epigenetic changes and Foxp3 expression are independent and complementary events
                 21.  Chakraborty AK, Weiss A: Insights into the initiation of TCR signaling. Nat Immunol   required for Treg cell development. Immunity 37:785–799, 2012.
                  15:798–807, 2014.                                     58.  Abbas AK, Benoist C, Bluestone JA, et al: Regulatory T cells: Recommendations to sim-
                 22.  Guirado M, de Aós I, Orta T, et al: Phosphorylation of the N-terminal and C-terminal   plify the nomenclature. Nat Immunol 14:307–308, 2013.
                  CD3-ε–ITAM tyrosines is differentially regulated in T cells. Biochem Biophys Res Commun     59.  Curotto de Lafaille MA, Lafaille JJ: Natural and adaptive Foxp3+ regulatory T cells:
                  291:574–581, 2002.                                     More of the same or a division of labor? Immunity 30:626–635, 2009.
                 23.  Malissen B, Gregoire C, Malissen M, Roncagalli R: Integrative biology of T cell activa-    60.  Veiga-Parga T, Sehrawat S, Rouse BT: Role of regulatory T cells during virus infection.
                  tion. Nat Immunol 15:790–797, 2014.                    Immunol Rev 255:182–196, 2013.







          Kaushansky_chapter 76_p1175-1188.indd   1186                                                                  9/17/15   4:01 PM
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