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110 Part III: Epochal Hematology Chapter 7: Hematology of the Fetus and Newborn 111

12.4 (10.8–13.9) 0.89 (0.64–1.17) 33.5(26.6–40.3) 2.78 (1.56–4.00) 1.08(0.70–1.46) 1.06(0.62–1.50) 1.05(0.67–1.43)0 0.99(0.50–1.49) 0.92(0.50–1.58) 1.09(0.55–1.63) 1.06(0.70–1.52) 0.97(0.67–1.27) 1.08(0.52–1.64) 1.12(0.62–1.62) 0.92(0.50–1.36) 1.05(0.55–1.55) 0.97(0.57–1.37)

Adults

Day 180 12.3 (10.7–13.9) 0.88 (0.61–1.17) 35.5(28.1–42.9) 25.0 (19.7–30.3) 2.51 (1.50–3.87) 0.88(0.60–1.16) 0.91(0.55–1.27) 0.87(0.47–1.27) 0.73(0.50–1.09) 1.07(0.50–1.97) 0.86(0.36–1.36) 0.78(0.38–1.18) 0.86(0.49–1.34) 0.77(0.39–1.15) 0.86(0.56–1.16) 0.82(0.36–1.28) 1.04(0.46–1.62) 1.10(0.50–1.70)

Full-Term Infants Day 30 11.8 (10.0–14.3) 0.79 (0.53–1.26) 40.4(32.0–55.2) 25.5 (19.8–31.2) 2.70 (1.62–3.78) 0.68(0.34–1.02) 0.98(0.62–1.34) 0.90(0.42–1.38) 0.91(0.50–1.57) 1.28(0.50–2.46) 0.51(0.21–0.81) 0.59(0.31–0.87) 0.53(0.27–0.79) 0.49(0.17–0.81) 0.57(0.23–0.91) 0.77(0.33–1.21) 0.93(0.39–1.47) 1.11(0.39–1.73)

13.0 (10.1–15.9) 1.00 (0.53–1.62) 42.9(31.3–54.5) 24.3 (19.4–29.2) 2.83 (1.67–3.99) 0.48(0.26–0.70) 0.72(0.34–1.08) 0.66(0.28–1.04) 1.00(0.50–1.78) 1.53(0.50–2.87) 0.53(0.15–0.91) 0.40(0.12–0.68) 0.38(0.10–0.66) 0.53(0.13–0.93) 0.37(0.18–0.69) 0.54(0.06–1.02) 0.79(0.27–1.31) 0.76(0.30–1.22)

Day 1

Reference Values for Coagulation Tests in Preterm and Full-Term Infants*

Day 180 12.5 (10.0–15.0) 0.91 (0.53–1.48) 37.5(27.2–53.5) 23.5 (19.0–28.3) 2.28 (1.50–3.60) 0.87(0.51–1.23) 1.02(0.58–1.46) 0.99(0.47–1.51) 0.99(0.50–1.87) 0.98(0.54–1.58) 0.81(0.50–1.20) 0.77(0.35–1.19) 0.78(0.46–1.10) 0.82(0.22–1.42) 0.78(0.40–1.16) 0.83(0.41–1.25) 1.13(0.65–1.61) 1.15(0.67–1.63) APTT, activated partial thromboplastin time; HK, high-molecular-weight kininogen; INR, international normalized ratio; PK, prekallikrein; PT, prothrombin time; TCT, thrombin clotting *All factors except fibrinogen are expressed as units per milliliter (U/mL), where pooled plasma

Preterm 30–36-Week Infants Day 30 11.8 (10.0–13.6) 0.79 (0.53–1.11) 44.7(26.9–62.5) 25.2 (18.9–31.5) 2.54 (1.50–4.14) 0.57(0.36–0.95) 1.02(0.48–1.56) 0.83(0.21–1.45) 1.11(0.50–1.99) 1.36(0.66–2.16) 0.44(0.13–0.80) 0.56(0.20–0.92) 0.43(0.15–0.71) 0.43(0.11–0.75) 0.59(0.31–0.87) 0.64(0.16–1.12) 0.99(0.51–1.47) 1.07(0.57–1.57)

13.0 (10.6–16.2) 1.0 (0.61–1.70) 53.6(27.5–79.4) 24.4 (18.8–29.9) 2.43 (1.50–3.73) 0.45(0.20–0.77) 0.88(0.41–1.44) 0.67(0.21–1.13) 1.11(0.50–2.13) 1.36(0.78–2.10) 0.35(0.19–0.65) 0.41(0.11–0.71) 0.30(0.08–0.52) 0.38(0.10–0.66) 0.33(0.09–0.57) 0.49(0.09–0.89) 0.70(0.32–1.08) 0.81(0.35–1.27) population. The range of values encompassing 95 percent of the population is shown in parentheses.

Day 1 haemostasis: Secondary haemostasis. Sem in Fetal and Neonatal Medicine 16:294–300, 2011.

Preterm 28–31-Week Infants Day 1 15.4 (14.6–16.9) 108(80.0–168) 24.8 (19.2–30.4) 2.56 (1.60–5.50) 0.31(0.19–0.54) 0.65(0.43–0.80) 0.37(0.24–0.76) 0.79(0.37–1.26) 1.41(0.83–2.23) 0.18(0.17–0.20) 0.36(0.25–0.64) 0.23(0.11–0.33) 0.25(0.05–0.35) 0.26(0.15–0.32) 0.32(0.19–0.52)

TABLE 7–6. Coagulation Test PT(s) INR APTT(s) TCT(s) Fibrinogen (g/L) II (U/mL) V (U/mL) VII (U/mL) VIII (U/mL) VWF (U/mL) IX (U/mL) X (U/mL) XI (U/mL) XII (U/mL) PK (U/mL) HK (U/mL) XIIIa (U/mL) XIIIb (U/mL) time; VWF, von Willebrand factor.

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