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1612 Part XI: Malignant Lymphoid Diseases Chapter 97: Hodgkin Lymphoma 1613

TABLE 97–3. Combination Chemotherapy for Hodgkin Lymphoma
2
Drug Dose (mg/m ) Route Schedule (Days Administered) Cycle Length (Days)
ABVD 28
Doxorubicin 25 IV 1, 15
Bleomycin 10 IV 1, 15
Vinblastine 6 IV 1, 15
Dacarbazine 375 IV 1, 15
COPP 28
Cyclophosphamide 650 IV 1, 8
Vincristine 1.4* IV 1, 8
Procarbazine 100 PO 1–14
Prednisone 40 PO 1–14
COPP/ABVD 28
Alternate cycles of COPP with ABVD
BEACOPP (Standard) 21
Bleomycin 10 IV 8
Etoposide 100 IV 1–3
Doxorubicin 25 IV 1
Cyclophosphamide 650 IV 1
Vincristine 1.4* IV 8
Procarbazine 100 PO 1–7
Prednisone 40 PO 1–14
BEACOPP (Escalated) 21
Bleomycin 10 IV 8
Etoposide 200 IV 1–3
Doxorubicin 35 IV 1
Cyclophosphamide 1250 IV 1
Vincristine 1.4* IV 8
Procarbazine 100 PO 1–7
Prednisone 40 PO 1–14
G-CSF (+) SQ 8+
BEACOPP (14-day) 14
Standard BEACOPP given every 14 days with growth factor support.
STANFORD V 12 weeks
Nitrogen mustard 6 IV day 1 on wk 1, 5, 9
Doxorubicin 25 IV day 1 on wk 1, 3, 5, 7, 9, 11
Vinblastine 6 IV day 1 on wk 1, 3, 5, 7, 9, 11
Vincristine 1.4* IV day 1 on wk 2, 4, 6, 8, 10, 12
Bleomycin 5 IV day 1 on wk 2, 4, 6, 8, 10, 12
Etoposide 60 × 2 IV day 1 & 2 on wk 3, 7, 11
Prednisone 40 PO day 1 on wk 1–10, taper
G-CSF for dose reduction, delay
G-CSF, granulocyte colony-stimulating factor; SQ, subcutaneously.
*Capped at 2 mg.

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