Page 1911 - Williams Hematology ( PDFDrive )

1886 Part XII: Hemostasis and Thrombosis Chapter 112: Platelet Morphology, Biochemistry, and Function 1887

leukemia, which may partially account for the thromboprotection noted 23. Kuijpers MJ, et al: Complementary roles of glycoprotein VI and alpha2beta1 integrin
in that disorder. 1803 CD39 is localized to lipid raft-like caveolae in the in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J
17(6):685–687, 2003.
plasma membrane, and the cholesterol content may control enzymatic 24. Matsuno K, et al: Inhibition of platelet adhesion to collagen by monoclonal anti-CD36
activity. It contains two putative transmembrane regions separated by antibodies. Br J Haematol 92(4):960–967, 1996.
an extracellular domain with six glycosylation sites and apyrase-like 25. Nakamura T, et al: Activation of the GP IIb-IIIa complex induced by platelet adhe-
regions that confer the ecto-ADPase activity. A related molecule, ATP- sion to collagen is mediated by both alpha2beta1 integrin and GP VI. J Biol Chem
274(17):11897–11903, 1999.
and ATPase 2, which is found on the basolateral surface of endothelial 26. Nieswandt B, Watson SP: Platelet-collagen interaction: Is GPVI the central receptor?
cells, the adventitia of some blood vessels, and microvascular pericytes, Blood 102(2):449–461, 2003.
is relatively selective for ATP, and thus it has the capacity to increase 27. Saelman EU, et al: Platelet adhesion to collagen types I through VIII under condi-
platelet aggregation by enhancing the production of ADP from ATP. 1799 tions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin). Blood 83(5):
1244–1250, 1994.
The physiologic roles of the NTPDases are complex because of their 28. Savage B, Almus-Jacobs F, Ruggeri ZM: Specific synergy of multiple substrate-receptor
production of variably prothrombotic and antithrombotic agents. It has interactions in platelet thrombus formation under flow. Cell 94(5):657–666, 1998.
been postulated that recruitment of microparticles enriched in mono- 29. Watson SP: Collagen receptor signaling in platelets and megakaryocytes. Thromb Hae-
most 82(2):365–376, 1999.
cyte CD39/NTPDase1 to thrombi could contribute to the limitation of 30. Coller BS, Shattil SJ: The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: A technology-
the size of platelet thrombi. A role for CD39/NTPDase1 in ischemia driven saga of a receptor with twists, turns, and even a bend. Blood 112(8):3011–3025,
2008.
reperfusion and allograft rejection has also been proposed. Mouse mod- 31. Naik UP, Naik MU: Association of CIB with GPIIb/IIIa during outside-in signaling is
els support the potential of modulating graft rejection and thrombosis required for platelet spreading on fibrinogen. Blood 102(4):1355–1362, 2003.
by using gene therapy to increase CD39/NTPDase1. A soluble recombi- 32. Patel D, et al: Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in plate-
nant form of CD39 inhibits platelet aggregation and recruitment in vitro let adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy.
Blood 101(3):929–936, 2003.
and may have potential as an anti-thrombotic agent in vivo. 1804 33. Shattil SJ: Regulation of platelet anchorage and signaling by integrin alpha IIb beta 3.
Thromb Haemost 70(1):224–228, 1993.
REFERENCES 34. Shattil SJ: Signaling through platelet integrin alpha IIb beta 3: Inside-out, outside-in,
and sideways. Thromb Haemost 82(2):318–325, 1999.
35. Shattil SJ, Newman PJ: Integrins: Dynamic scaffolds for adhesion and signaling in
1. Ruggeri ZM: Platelets in atherothrombosis. Nat Med 8(11):1227–1234, 2002. platelets. Blood 104(6):1606–1615, 2004.
2. Goldsmith HL, Turitto VT: Rheological aspects of thrombosis and haemostasis: 36. Weiss HJ, Turitto VT, Baumgartner HR: Further evidence that glycoprotein IIb-IIIa
Basic principles and applications. ICTH-Report—Subcommittee on Rheology of the mediates platelet spreading on subendothelium. Thromb Haemost 65(2):202–205, 1991.
International Committee on Thrombosis and Haemostasis. Thromb Haemost 55(3): 37. Santos MT, et al: Enhancement of platelet reactivity and modulation of eicosanoid
415–435, 1986. production by intact erythrocytes. A new approach to platelet activation and recruit-
3. de Groot PG, JJ Sixma: Perfusion chambers, in Platelets, edited by AD Michelson:, ment. J Clin Invest 87(2):571–580, 1991.
pp 575–586. Academic Press, San Diego, 2007. 38. Dubois C, Atkinson B, Furie B, Furie B: Real-time imaging of platelets during thrombus
4. Savage, Ruggeri ZM: Platelet thrombus formation in flowing blood, in Platelets, edited formation, in Platelets, edited by AD M, pp 611–626. Academic Press, San Diego, 2007.
by AD Michelson:, pp 359–376. Academic Press, San Diego, 2007. 39. Celi A, et al: Thrombus formation: Direct real-time observation and digital analysis of
5. Coller B: Platelets in cardiovascular thrombosis and thrombolysis, in The Heart thrombus assembly in a living mouse by confocal and widefield intravital microscopy.
and Cardiovascular System, edited by HA Fozzard, AM Katz, HE Morgan, E Haber: J Thromb Haemost 1(1):60–68, 2003.
pp 219–273. Raven Press, New York, 1991. 40. Denis C, et al: A mouse model of severe von Willebrand disease: Defects in hemostasis
6. Jackson SP, Nesbitt WS, Westein E: Dynamics of platelet thrombus formation. J and thrombosis. Proc Natl Acad Sci U S A 95(16):9524–9529, 1998.
Thromb Haemost 7 Suppl 1:17–20, 2009. 41. Ni H, et al: Persistence of platelet thrombus formation in arterioles of mice lacking
7. Roth GJ: Developing relationships: Arterial platelet adhesion, glycoprotein Ib, and both von Willebrand factor and fibrinogen. J Clin Invest 106(3):385–392, 2000.
leucine-rich glycoproteins. Blood 77(1):5–19, 1991. 42. Peerschke EI: The platelet fibrinogen receptor. Semin Hematol 22(4):241–259, 1985.
8. Ruggeri ZM: Structure and function of von Willebrand factor. Thromb Haemost 43. Phillips DR, et al: The platelet membrane glycoprotein IIb-IIIa complex. Blood 71(4):
82(2):576–584, 1999. 831–843, 1988.
9. Andrews RK, et al: The glycoprotein Ib-IX-V complex in platelet adhesion and signal- 44. Plow EF, Ginsberg MH: Cellular adhesion: GPIIb-IIIa as a prototypic adhesion recep-
ing. Thromb Haemost 82(2):357–364, 1999. tor. Prog Hemost Thromb 9:117–156, 1989.
10. Ruggeri ZM: Von Willebrand factor, platelets and endothelial cell interactions. J 45. Plow EF, Pesho MM, Ma YQ: Integrin αIIβ3, in Platelets edited by AD Michelson. San
Thromb Haemost 1(7):1335–1342, 2003. Diego, Academic Press: 165–178, 2007.
11. Savage B, Ruggeri ZM: Platelet thrombus formation in flowing blood, in Platelets, 46. Peerschke EI: Ca+2 mobilization and fibrinogen binding of platelets refractory to ade-
edited by AD Michelson: p 215. Academic Press, San Diego, 2002. nosine diphosphate stimulation. J Lab Clin Med 106(2):111–122, 1985.
12. Mailhac A, et al: Effect of an eccentric severe stenosis on fibrin(ogen) deposition 47. Steen VM, Holmsen H: Synergism between thrombin and epinephrine in human
on severely damaged vessel wall in arterial thrombosis. Relative contribution of platelets: Different dose-response relationships for aggregation and dense granule
fibrin(ogen) and platelets. Circulation 90(2):988–996, 1994. secretion. Thromb Haemost 54(3):680–683, 1985.
13. Moake JL, et al: Involvement of large plasma von Willebrand factor (VWF) multimers 48. Ware JA, Smith M, Salzman EW: Synergism of platelet-aggregating agents. Role of
and unusually large VWF forms derived from endothelial cells in shear stress-induced elevation of cytoplasmic calcium. J Clin Invest 80(1):267–271, 1987.
platelet aggregation. J Clin Invest 78(6):1456–1461, 1986. 49. Giandomenico G, et al: The leptin receptor system of human platelets. J Thromb Hae-
14. Ikeda Y, et al: The role of von Willebrand factor and fibrinogen in platelet aggregation most 3(5):1042–1049, 2005.
under varying shear stress. J Clin Invest 87(4):1234–1240, 1991. 50. Konstantinides S, et al: Leptin-dependent platelet aggregation and arterial throm-
15. Ruggeri ZM: Mechanisms of shear-induced platelet adhesion and aggregation. bosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest
Thromb Haemost 70(1):119–123, 1993. 108(10):1533–1540, 2001.
16. Andrews RK, Lopez JA, Berndt MC: The GPIb-IX-V complex, Platelets, edited by 51. Konstantinides S, et al: Inhibition of endogenous leptin protects mice from arterial
AD M, pp 145–164. Academic Press, San Diego, 2007. and venous thrombosis. Arterioscler Thromb Vasc Biol 24(11):2196–2201, 2004.
17. Chiang TM, Rinaldy A, Kang AH: Cloning, characterization, and functional studies of 52. Andre P, et al: CD40L stabilizes arterial thrombi by a beta3 integrin—Dependent
a nonintegrin platelet receptor for type I collagen. J Clin Invest 100(3):514–521, 1997. mechanism. Nat Med 8(3):247–252, 2002.
18. Clemetson JM, et al: The platelet collagen receptor glycoprotein VI is a member of 53. Angelillo-Scherrer A, et al: Role of Gas6 receptors in platelet signaling during
the immunoglobulin superfamily closely related to FcalphaR and the natural killer thrombus stabilization and implications for antithrombotic therapy. J Clin Invest
receptors. J Biol Chem 274(41):29019–29024, 1999. 115(2):237–246, 2005.
19. Clemetson KJ: Platelet collagen receptors: A new target for inhibition? Haemostasis 54. Balogh I, et al: Analysis of Gas6 in human platelets and plasma. Arterioscler Thromb
29(1):16–26, 1999. Vasc Biol 25(6):1280–1286, 2005.
20. Coller BS, et al: Collagen-platelet interactions: Evidence for a direct interaction of 55. Gould WR, et al: Gas6 receptors Axl, Sky and Mer enhance platelet activation and
collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa regulate thrombotic responses. J Thromb Haemost 3(4):733–741, 2005.
mediated by adhesive proteins. Blood 74(1):182–192, 1989. 56. Maree AO, et al: Growth arrest specific gene (GAS) 6 modulates platelet thrombus for-
21. Gruner S, et al: Multiple integrin-ligand interactions synergize in shear-resistant mation and vascular wall homeostasis and represents an attractive drug target. Curr
platelet adhesion at sites of arterial injury in vivo. Blood 102(12):4021–4027, 2003. Pharm Des 13(26):2656–2661, 2007.
22. Kato K, et al: The contribution of glycoprotein VI to stable platelet adhesion and throm- 57. Saller F, et al: Role of the growth arrest-specific gene 6 (gas6) product in thrombus
bus formation illustrated by targeted gene deletion. Blood 102(5):1701–1707, 2003. stabilization. Blood Cells Mol Dis 36(3):373–378, 2006.

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