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1942           Part XII:  Hemostasis and Thrombosis                                                                                        Chapter 113:  Molecular Biology and Biochemistry of the Coagulation Factors           1943





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               ROLE OF FIBRINOLYSIS                                      Biol Chem 393:889–898, 2012.
                                                                        21.  Lechtenberg BC, Johnson DJ, Freund SM, Huntington JA: NMR resonance assignments
               Once a hemostatic clot has been formed and protected from fibrinolysis   of thrombin reveal the conformational and dynamic effects of ligation. Proc Natl Acad
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               The Concept of Basal Coagulation and Anticoagulation     24.  Xu WF, Andersen H, Whitmore TE, et al: Cloning and characterization of human pro-
                                                                         tease-activated receptor 4. Proc Natl Acad Sci U S A 95:6642–6646, 1998.
               The coagulation process only proceeds when enough thrombin is gen-    25.  Coughlin SR: Protease-activated receptors in hemostasis, thrombosis and vascular biol-
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               platelets and cofactors. One may wonder, however, if minute hemostatic     26.  Spronk HM, de Jong AM, Crijns HJ, et al: Pleiotropic effects of factor Xa and thrombin:
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               plugs are not constantly formed throughout the body to maintain the     27.  Coppens M, Eikelboom JW, Gustafsson D, et al: Translational success stories: Develop-
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               activation probably occurs at all times.  More than 30 years ago, it     28.  Hauel NH, Nar H, Priepke H, et al: Structure-based design of novel potent nonpeptide
                                            397
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               was shown that fibrinopeptides are continuously cleaved from fibrin-    29.  Royle NJ, Irwin DM, Koschinsky ML, et al: Human genes encoding prothrombin and
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          Kaushansky_chapter 113_p1915-1948.indd   1942                                                                 9/21/15   2:41 PM
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