Page 2357 - Williams Hematology ( PDFDrive )

2330 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2331

TABLE 136–1. Characteristics of International Society of Blood Transfusion Defined Blood Group Systems and Antigen
Collections (Continued)
Function of RBC
ISBT ISBT Gene Membrane
Conventional Symbol Chromosome Name (ISGN If Associated Antigens Component
Name (No.) Location Different) [Null Phenotype] (CD No.) Disease Association
BLOOD GROUP SYSTEMS
ABO ABO (001) 9q34.2 ABO A, B, A, B, A1 Glycocalyx Altered expression in
[group O] some hematologic
disorders
MNS MNS (002) 4q31.21 MNS (GYPA, M, N, S, s, U, and 43 Binds microbe Decreased Plasmodium
GYPB) more [En(a–); U–; glycocalyx, falciparum invasion, may
M M ] complement regu- be receptor for Escherichia
k
k
lation, chaperone coli
for band 3 (CD235)
k
P1PK P1PK (003) 22q13.2 P1 (A4GALT) P1, P , NOR Glycocalyx
Rh RH (004) 1p36.11 RHD, RHCE (RH) D, C, E, c, e, and 49 Possibly transports Hemolytic anemia, hered-
more [Rh ] CO or NH (CD240) itary stomatocytosis,
null 2 3
hematologic malignancies
Lutheran LU (005) 19q13.32 LU Lu , Lu , Lu3, and Binds laminin Increased expressions
b
a
18 more [recessive (CD239) possibly involved in
Lu(a–b–)] vasoocclusion in sickle cell
disease
Kell KEL (006) 7q34 KEL K, k, Kp , Kp , Js , Js , Cleaves big endo-
a
b
a
b
and 29 more [K or thelin-3 to ET-3, a
K ] 0 potent vasocon-
null
strictor (CD238)
a
b
b
Lewis LE (007) 19p13.3 LE (FUT3) Le , Le , and 4 more Glycocalyx, Le is Increased expression in
[Le(a–b–)] receptor for Helico- fucosidosis, Lewis anti-
bacter pylori bodies may be important
in graft rejection
Duffy FY (008) 1q23.2 FY (DARC) Fy , Fy , Fy3, Fy5, Fy6 Chemokine, Plas- Resistance to P. vivax
b
a
[Fy(a–b–)] modium vivax invasion
receptor (CD234)
Kidd JK (009) 18q12.3 JK(HUT11, Jk , Jk , Jk3 [Jk(a–b–)] Urea transporter Impaired urea transport,
a
b
SLC14AI) urine-concentrating
defect
Diego DI (010) 17q21.31 DI (SLC4A1; AE1) Di , Di , Wr , Wr , and Anion exchanger Southeast Asian ovalocy-
a
b
a
b
18 more (CD233), Band tosis, hereditary sphero-
3 cytoskeletal cytosis, renal tubular
protein acidosis
Yt YT(011) 7q22.1 Yt (ACHE) Yt , Yt b Acetylcholin- Absent from PNH III RBCs
a
esterase
Xg XG (012) Xp22.33 XG (XG, MIC2) Xg , CD99 Adhesion mole-
a
cules (CD99)
Scianna SC (013) 1p34.2 SC (ERMAP) Sc1, Sc2, Sc3, and 4 Possible adhesion
more [SC: –1, –2, –3]
Dombrock DO (014) 12p12.3 DO (ART4) Do , Do , Gy , Hy, Jo a Enzymatic (CD297) Absent from PNH III RBCs
a
b
a
and 3 more [Gy(a–)]
b
a
Colton CO (015) 7p14.3 CO (AQP1) Co , Co , Co3, Co4 Water transport Monosomy 7, inability to
[Co(a–b–)] maximally concentrate
urine, congenital dysery-
thropoietic anemia
Landsteiner- LW (016) 19p13.2 LW (ICAM4) LW , LW , LW Binds CD11/CD18, Depressed in pregnancy
a
ab
b
Wiener [LW(a–b–)] ligand for integrins and some malignant
(CD242) diseases
Chido/Rogers CH/RG 6p21.32 C4A,C4B CH1, RGl, and 7 more Complement Certain phenotypes have
(017) components increased susceptibility to
certain autoimmune con-
ditions and infections
(continued )
Kaushansky_chapter 136_p2327-2352.indd 2331 9/21/15 4:30 PM