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2332 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2333

TABLE 136–1. Characteristics of International Society of Blood Transfusion Defined Blood Group Systems and Antigen
Collections (Continued)
Function of RBC
ISBT ISBT Gene Membrane
Conventional Symbol Chromosome Name (ISGN If Associated Antigens Component
Name (No.) Location Different) [Null Phenotype] (CD No.) Disease Association
Vel VEL (034) 1p36.32 VEL, SMIM1 Vel [Vel-] CD59
CD59 CD59 (035) 1p13.33 CD59 CD59.1 [CD59-] Complement regu- Absent from PNH III RBCs
lation (CD59)
Antigen Collections
Cost COST (205) — — Cs , Cs b
a
Ii I (207) — — i
Er ER (208) — — Er , Er , Er3
a
b
GLOB (209) — — LKE,
Unnamed: — — Le , Le d
c
(210)
MN CHO — — Hu, M , Tm, Can, Sext,
1
(213) Sj
Low-incidence — (700) — — 17
series
High-incidence — (901) — — At , Emm, AnWj, Sd ,
a
a
series PEL, ABTI, MAM
CGD, chronic granulomatous disease; ISGN, International Society for Gene Nomenclature; PNH, paroxysmal nocturnal hemoglobinuria; RBC,
red blood cell.
Data from Daniels GL, Anstee DJ, Cartron J-P, et al: Blood group terminology 1995. ISBT working party on terminology for red cell surface
antigens. Vox Sang 69:265, 1995; Issitt PD, Anstee DJ: Applied Blood Group Serology, 4th ed. Montgomery Scientific, Durham, NC, 1998; Reid
ME, Lomas-Francis C, Olsson ML: Blood Group Antigen FactsBook, 3rd. Academic Press, San Diego, 2012; Reid ME, Lomas-Francis C: Blood Group
Antigens & Antibodies: A Guide to Clinical Relevance & Technical Tips. Star Bright Books, New York, 2007; www.isbt-web.org.

TABLE 136–2. Summary of Common Blood Group Systems or Collections and Their Antigens (Continued)
Antigen
Blood No. Antigen Distribution
Group Frequency Copies on in Blood,
(Year Common White/ Adult RBC Dosage (See Cord Cell Fluids, and
Reported) Phenotypes Black (%) × 10 3 Text) Expression Biochemistry Tissues Comments
ABO (1900) A 40/27 AB: A/B: not Weak: Carbohy- RBC, lymphs, Most significant
B 11/20 ~800–1000 evident ~1/3 adult drate on plts antigens in
AB 4/4 expression types 1, 2, 3, transfusion and
and 4 precur-
transplantation
sor chains
H (1948) O 45/29 H: ~1700 H expression Weak Attached Plasma, Weak subgroups
depends Main RBC to lipids in secretions; result from variant
on ABO: carrier: bands plasma and broad tissue transferases
O>A >B> 3 and 4.5 protein in distribution;
2
A B>A >A B secretions most epithe-
2 1 1
lial/endothe-
lial cells
Rh (1939) R Dce 42/17 D on R R : D: not Normal adult Multipass, Erythroid D most significant
1 2 2
r ce 37/26 15–33 evident nonglycosy- specific antigen after A
R DcE 14/11 R R : 14–19 C and c: yes lated protein: Possible and B
2 1 1 30–32 cation Three causes for
R Dce 4/44 R r: 12–20 E and e: yes kDa; 417 aa
0 0 transport weak D expression
r’ Ce 2/2 R r: 9–14 C: serine (see text)
1 Possible
r″ cE 1/0 c on cc: 103/c: pro- role in RBC Nulls: amorphic
70–85 line 103 membrane type and regulator
E: proline integrity type
226/e:
alanine 226
(continued )

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