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2334 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2335

TABLE 136–2. Summary of Common Blood Group Systems or Collections and Their Antigens (Continued)
Antigen
Blood No. Antigen Distribution
Group Frequency Copies on in Blood,
(Year Common White/ Adult RBC Dosage (See Cord Cell Fluids, and
Reported) Phenotypes Black (%) × 10 3 Text) Expression Biochemistry Tissues Comments
R DCE <1 Cc: 37–53 Forms “Rh
z
r CE <1 e on ee: complex”
y
18–24 with LW,
GPB, and
Ee: 13–14 Rh-related
glycoprotein
(chromo-
some 6)
Lewis Le(a+b–) 22/23 Le : ~3 Not evident Weak: adult Carbohy- Plasma and Le antigens
a
(1946) Le(a–b+) 72/55 expression at drate on type secretion depend on Le/Se
Le(a–b–) 6/22 age 2 years 1 precursor antigen; on interaction; Le/Se
chains only
RBC, lymphs, = Le(a–b+), ABH
Le(a+b+) Rare in Attached plts only by secretor; lele/sese
European to lipids in adsorption = Le(a+b–), ABH
popu- plasma and of plasma nonsecretor; lele =
lations; protein in antigen Le(a–b–), Sese sta-
found in secretions tus not apparent
Australasian Le(a–b+) express
popula- some Le , do not
a
tions; 10 in make anti-Le .
a
Japanese Women test
Le(a–b–) during
pregnancy
I (1956) l adult(↑↑I↓i) Common I: ~500 Not evident Strong i; Carbohy- Broad tissue I and i expression
i cord (↓I↑i) Common weak I. drate on ABH distribution; are inversely pro-
i adult <1:10,000 Adult expres- active chains; RBCs, plts, portional but not
lymphs,
products of alleles
lipid on RBC;
(↓I↑↑i) sions at age 2 protein in granules,
years
plasma monos; also
in plasma,
secretions
(e.g., milk,
saliva, urine)
P1PK and GLOB
P1 (1927) P : 1 79/94 P1: ~500 Not evident, Weak: adult Carbohy- RBC, lymphs, P1-like antigen
GLOB P : 2 21/6 Globoside: but inherited expression drate on RBC plts, monos, is associated
(1951) p: P –P–P1– Rare ~15,000 variations by 7 years and plasma fibroblasts, with pigeon and
k
glycolip-
exist; e.g., P1
uroepithelial
earthworm pro-
may be nor- ids; not in cells tein and parasitic
mal, strong, secretions infections
or weak
MNS M+N– 28/26 GPA: ~800 Yes Normal adult Single-pass RBCs plus GPA and GPB carry
M+N+ 50/44 GPB: ~200 sialogly- renal multiple antigens
(M: 1927) M–N+ 22/30 coprotein capillary and many hybrids
type 1
epithelial/
of GPA–GPB
(S: 1947) S+s– 11/3 GPA: 43 kDa, endothelium Can have absence
S+s+ 44/28 131 aa, car- of GPA, GPB, or
S–s+ 45/69 ries MN both
S–s–U– 0/<1 GPB: 25 kDa,
72 aa, carries
SsU; part of
Rh complex
Kell (1946) K–k+ 91/98 Kell: 2–6 Yes Normal adult Single-pass Kell: RBC plus System of
glycoprotein marrow and high- and low-
type II highly fetal liver frequency
folded: tissue; not on antigens
93kDa, 732 brain, kidney,
aa adult liver
(continued )

Kaushansky_chapter 136_p2327-2352.indd 2334 9/21/15 4:30 PM