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2332 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2333

TABLE 136–1. Characteristics of International Society of Blood Transfusion Defined Blood Group Systems and Antigen
Collections (Continued)
Function of RBC
ISBT ISBT Gene Membrane
Conventional Symbol Chromosome Name (ISGN If Associated Antigens Component
Name (No.) Location Different) [Null Phenotype] (CD No.) Disease Association
H H (018) 19q13.33 H (FUT1) H [Bombay, O ] Glycocalyx (CD Decreased in some tumor
h
173) cells, increased in hemato-
poietic stress
Kx XK (019) Xp21.1 XK Kx [McLeod] Possible neuro- Acanthocytosis, muscular
transmitter, func- dystrophy, hemolytic ane-
tion in RBCs not mia; McLeod syndrome
known sometimes associated
with CGD, peripheral neu-
ropathy, cardiomyopathy
seizures, a late-onset
dementia, and behavioral
changes
Gerbich GE (020) 2q14.3 GE (GYPC) Ge2, Ge3, Ge4, Membrane attach- Hereditary elliptocyto-
and 8 more [Leach ment; interacts sis, hemolytic anemia,
phenotype] with 4.1R and p55 decreased 4.1R and p55
(CD236)
c
a
Cromer CROM 1q32.2 CROM (CD55; Cr , Tc , Tc , Tc , Dr , Complement Absent from PNH III RBCs,
b
a
a
a
(021) DAF) and 13 more [Inab regulation, binds Dr is the receptor for uro-
phenotype] C3b, disassembles pathogenic E. coli
C3/C5 convertase
(CD55)
Knops KN (022) 1q32.2 KN (CR1) Kn , Kn , McC , SI , Yk , Complement reg- Antigens depressed in
b
a
a
a
a
and 4 more [Helge- ulation, binds C3b certain autoimmune and
son phenotype] and C4b, mediates malignant conditions
phagocytosis
(CD35)
Indian IN (023) 11p13 IN (CD44) In , In , INFI, INJA Binds hyaluronic Depressed in pregnancy,
b
a
acid, mediates congenital dyserythropoi-
adhesion of leuko- etic anemia
cytes (CD44)
Ok OK (024) 19p13.3 OK (BSG) Ok , OKGV, Possible adhesion
a
OKVM (CD147)
Raph RAPH (025) 11p15.5 MER2 (CD151) MER2 [RAPH ] Adhesion molecule Renal disease, associated
null
involved in kidney with pretibial epidermoly-
function (CD151) sis bullosa and sensori-
neural deafness
John Milton JMH (026) 15q24.1 JMH (SEMA7A) JMH, and 5 more Adhesion mole- Absent from PNH III RBCs
Hagen cule, function in
RBCs not known
(CD108)
I I (027) 6p24.2 GCNT2 I [I–; i adult] Glycocalyx Congenital cataracts in
Asians
GLOB Globoside 3q26.1 P (β3GALNT1) P, PX2 [P–] Glycocalyx Receptor E. coli and parvo-
(028) virus B19
Gil GIL (029) 9p13.3 GIL (AQP3) GIL [GIL–] Glycerol/water/
urea transporter
Rh-associated RHAG (030) 6p21.3 RHAG Duclos, and 3 more Possibly trans- Hemolytic anemia, heredi-
glycoprotein ports CO , or NH tary stomatocytosis
3
2
(CD241)
FORS FORS (031) 9q34.2 GBGT1 FORS1 Glycocalyx
JR JR (032) 4q22.1 JR, ABCG2 Jr [Jr(a–)] ATP-dependent
a
transporter
Lan LAN (033) 2q36 LAN, ABCB6 Lan [Lan–] ATP-dependent
transporter
(continued )

Kaushansky_chapter 136_p2327-2352.indd 2332 9/21/15 4:30 PM