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 2408  Index                                                                                            Index         2409



                  Camptotheca acuminata, 326          Cangrelor, 404t, 405, 2076            erythrocytosis and, 871, 872, 876, 881
                  Camptothecins, 319t, 326–328        CANNTG (consensus E-box motifs), 262  fibrinolytic system in, 1974–1976, 1974t,
                  Campylobacter, 820, 1212, 1216, 1574, 1664  Cao Gio, 2107                       1975f
                  Campylobacter jejuni, 1790          CAPS (catastrophic antiphospholipid   heart valve hemolysis, 804–806, 805t, 806f
                  CAMT (congenital amegakaryocytic           syndrome), 2239, 2245          hemochromatosis and, 642
                         thrombocytopenia), 530t, 532,   CapZ, 1833t, 1839f, 1840           in hemolytic uremic syndrome, 2259
                         1822                         CAR (chimeric antigen receptor), 415–416,   in hemophilia, 2130
                  Canale-Smith syndrome. See Autoimmune      415f, 438, 442, 454, 1193      hereditary thrombophilia and, 2226–2227
                         lymphoproliferative syndrome   Carbamazepine, megaloblastic anemia and,   history of, 5
                         (ALPS)                              606t                           Hodgkin lymphoma treatment and, 1618
                  cANCA (cytoplasmic antineutrophil   Carbohydrates                         monocytes/macrophages in, 1079
                         cytoplasmic antibody), 1013    antigens, 2337, 2338f               myocardial infarction. See Myocardial
                  Cancer. See also individual types     in erythrocytes, 471t                     infarction (MI)
                    ataxia-telangiectasia and, 1226–1227  loading, for acute intermittent porphyria,   neutrophilia and, 1001
                    cellular senescence and, 132             904                            primary lymphoma, 1581
                    chemotherapy. See Antineoplastic drugs/  metabolism in neutrophils, 932  red cell transfusion in, 6–7, 2370t
                         chemotherapy                 Carbonic anhydrase I, 701t            regenerative therapies for, 450
                    disseminated intravascular coagulation in,   Carbonic anhydrase II, 701t  risk factors, 2281–2282, 2282t, 2288
                         803–804, 2207–2208           Carbon monoxide (CO), in red cell life span   in sickle cell disease, 769
                    HIV-associated. See Human                measurement, 496               thrombophilia testing in, 2228–2229
                         immunodeficiency virus       Carbon monoxide poisoning             in thrombotic thrombocytopenic purpura,
                         (HIV)–associated malignancies  clinical and laboratory features, 795     2255
                    immune cell therapy. See Immune cell   epidemiology, 795                vulnerability to, 2289–2291, 2290f, 2291t.
                         therapy (adoptive cellular therapy),   etiology and pathogenesis, 795    See also Atherosclerosis
                         of malignancy                  therapy, course, and prognosis, 795–796  Carfilzomib, 342–343, 342f
                    lymphocytosis and, 1204           Carbonyl iron, 638                    mechanism of action, 241
                    marrow infiltration in, 658, 659f  Carboplatin                          for myeloma, 1750–1751, 1753t, 1754
                    microangiopathic hemolytic anemia and,   adverse effects, 330           for Waldenström macroglobulinemia, 1794
                         803–804, 803t                  for diffuse large B-cell lymphoma, 1629t,   Carmustine (BCNU)
                    monocytosis and, 1097                    1631                           aplastic anemia and, 516
                    neutrophilia and, 1001              high-dose, 331t, 332t               for diffuse large B-cell lymphoma, 1632
                    next-generation sequencing analysis,   for Hodgkin lymphoma, 1616       doses and toxicities, 331, 332t, 368
                         160–161                        pharmacology, 330                   in hematopoietic cell transplantation
                    thrombotic microangiopathy in, 2262  Carboxyhemoglobin, 795–796               conditioning, 360
                    vaccine therapy for. See Vaccine therapy  Carbromal, 830                for Hodgkin lymphoma, 1616
                    venous thromboembolism in, 2276–2277  CARD (caspase activation and recruitment   for mycosis fungoides, 1685
                  Candida infections                         domain), 205, 298–299, 1025, 1054,   platelet function and, 2079
                    acute myelogenous leukemia treatment     1230                          Carotid endarterectomy, 2297
                         and, 1410                    CARD9, 1230                          Carrier, 147
                    in chronic granulomatous disease, 1021  CARD11, 233t, 235t, 236t       Carrión disease, 818
                    disseminated, 2104–2105, 2105f    Cardiacos negros, 871                CAR-T (chimeric antigen receptor T) cells,
                    after hematopoietic cell transplantation,   Cardiac output, anemia and, 505   1539
                         1182                         CARDIF. See Mitochondrial antiviral   Cartilage hair hypoplasia, 993, 1226
                    in hyperimmunoglobulin E syndrome,       signaling protein (MAVS)      Caspase activation and recruitment domain
                         1026, 1225                   Cardiolipin, 1955                           (CARD), 205, 298–299, 1025, 1054,
                    in immunocompromised host, 383    Cardiopulmonary bypass, 2085–2086, 2318,    1065f, 1230
                    in Langerhans cell histiocytosis, 1104   2384                          Caspases
                    in leukocyte adhesion deficiency, 1023  Cardiovascular disease. See also Vascular   activation, 204–205, 204f, 1065f
                    in newborn, 106                          disease/injury                 in apoptosis, 203–204
                    pattern-recognition signaling defects with   in acute myelogenous leukemia, 1381,   in lymphoma, 210
                         increased susceptibility to, 1230   1410                           in T-cell therapy, 416
                    prevention, 389                     in AL amyloidosis, 1760, 1761, 1775,   Caspofungin, 385, 388t, 389
                    red cell antigens and susceptibility to, 2340  1775t, 1777–1779, 1778f, 1780f,   Castleman disease, 1249–1250, 1496t, 1573
                    in specific granule deficiency, 1021     1781                          Catalase, 286
                    Th17 T cells and, 369               anthracycline-induced, 1520         abnormalities, 701t
                    treatment, 385                      in antiphospholipid syndrome, 2240  activity, 692t








          Kaushansky_index_p2393-2506.indd   2409                                                                       9/21/15   3:21 PM
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