Page 2446 - Williams Hematology ( PDFDrive )

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2416 Index Index 2417

protein Z-dependent protease inhibitor, inhibitors, 1991 laboratory features, 603, 994
1960 antithrombin. See Antithrombin (AT) neural tube defects and, 598
tissue factor pathway inhibitor. See protein Z, 1938, 1952t neurologic effects, 602
Tissue factor pathway inhibitor protein Z-dependent protease inhibitor, pregnancy and, 120
(TFPI) 1916t, 1938, 1952t, 1960 subtle, 602–603
in inflammation, 286t, 290 tissue factor pathway inhibitor. See therapy, course, and prognosis, 603–604,
metabolic modulation of, 2203 Tissue factor pathway inhibitor 604f
monocytes and macrophages in, 1059 (TFPI) thrombocytopenia and, 1997–1998
in neonate, 109–111, 110t, 111t procoagulant factors Cobalophilin. See Haptocorrins
in older adults, 137 factor V. See Factor V Cobblestone area-forming cell (CAFC), 260
pathways. See also Coagulation factors factor VII. See Factor VIII Cocaine, 2079
basal coagulation/anticoagulation and, soluble cofactors Coccidioides infection, 384, 385
1942 protein S. See Protein S Codanin-1, 565
cascade model, 1938–1939 von Willebrand factor. See Von Codocytes (target cells), 21, 21f, 473f, 473t,
cell-based model, 1940, 1940f Willebrand factor (VWF) 474f, 475
endothelial cells in, 1941–1942, 1941f vitamin K–dependent zymogens, 1915– CODOX-M/IVAC regimen, for Burkitt
fibrinolysis in, 1942 1918, 1916t, 1917f, 1918f, 1918t lymphoma, 1245, 1675, 1675t
immune cells in, 1940–1941, 1941f factor VII. See Factor VII Coenzymes, in erythrocytes, 470t
plasma protease inhibitors in, 1942 factor IX. See Factor IX Cofilin, 1833t
platelet activation in, 1842, 1940, 1940f factor X. See Factor X COH1, 994
protein C pathway and, 1949–1951, protein C. See Protein C Cohen syndrome, 994
1950f prothrombin. See Prothrombin (factor Cohort methods, for red cell life span
revised model, 1939–1940, 1939f II) measurement, 495, 496f
Coagulation factors Cobalamin, 588–593 Coin rubbing, purpura and, 2107
aging and, 135 cell uptake, 592 Colchicine
cell-associated chemistry, 588f, 589f for familial Mediterranean fever, 1025–
endothelial protein C receptor. See daily requirements, 589 1026
Endothelial protein C receptor intestinal absorption, 583, 591–592, 591t megaloblastic anemia and, 606t
(EPCR) metabolism, inborn errors of, 607, 607t Cold agglutinin disease, 823–824, 837,
thrombomodulin. See Thrombomodulin oral, 604 840, 1790. See also Autoimmune
(TM) plasma haptocorrin and, 592–593 hemolytic anemia, cold-antibody
tissue factor. See Tissue factor (TF) role in metabolism, 583, 589–590, 589f Cold agglutinins, 828, 829
contact system serum assay, 593 Cold-antibody hemolytic anemia. See
factor XII. See Factor XII sources, 589 Autoimmune hemolytic anemia,
high-molecular-weight kininogen, Cobalamin-binding proteins cold-antibody
1916t, 1929 childhood megaloblastic anemia and Collagen, 63
prekallikrein, 1929 defects in, 605, 607 interactions, 1846t
deficiencies. See also specific factors levels in disease, 593t platelet activation and, 1879–1881
acquired, 2145 Cobalamin C deficiency, 2263 structure, 1846t
antibody-mediated, 2183–2187 Cobalamin deficiency, 599–604. See also type III, 267, 1446, 1846t
assays, 1990 Pernicious anemia (PA) types I, V, VI, 267, 1846t
diagnosis, 1988, 1989f clinical features, 602–603, 602f Collagenases, 283
in hepatic disease, 2192 etiology and pathogenesis, 583, 596t, Collagen receptor. See Integrin α β
2 1
inherited. See Rare bleeding disorders 599–602 Collagen-related peptide (CRP), 1851
(RBDs) AIDS, 601–602 Colon
in pregnancy, 121 blind loop syndrome, 601 cancer, folic acid deficiency and, 599
in disseminated intravascular coagulation, in children, 605, 607 primary lymphomas in, 1581
2203 defective intrinsic factor secretion. See Colony-forming cell (CFC), 269
factor XI. See Factor XI Pernicious anemia (PA) Colony-forming unit (CFU), 269
fibrin network dietary deficiency, 602 Colony-forming unit-erythroid (CFU-E)
factor XIII. See Factor XIII fish tapeworm, 601 development, 462
fibrinogen. See Fibrinogen gastrectomy syndromes, 601 in erythropoiesis, 480f, 481, 483f
thrombin-activatable fibrinolysis intestinal disorders, 601 progenitors, 270
inhibitor. See Thrombin-activatable pancreatic disease, 602 Colony-forming unit–granulocyte-erythroid-
fibrinolysis inhibitor (TAFI) Zollinger-Ellison syndrome, 601 monocyte macrophage (CFU-
in inflammation, 2201 folate deficiency and, 590–591, 590f GEMM), 100

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