Page 2473 - Williams Hematology ( PDFDrive )

2444 Index Index 2445

Hepatic vein thrombosis, in polycythemia molecular determinants of clinical severity, erythrocyte membrane protein defects in,
vera, 1293 678–679 670–672, 670t
Hepatitis, aplastic anemia and, 518 therapy and prognosis, 679–680 ankyrin, 671–672
Hepatitis A virus, mononucleosis and, 1268 Hereditary erythroblastic multinuclearity band 3, 672
Hepatitis B virus (HBV) infection, 518, 1410, with a positive acidified serum test protein 4.2, 672
1574, 2126, 2370t (HEMPAS), 567, 2340 spectrin, 672
Hepatitis C virus (HCV) infection Hereditary folate malabsorption, 608 etiology and pathogenesis, 669–670,
antiphospholipid antibodies and, 2234, Hereditary hemochromatosis. See 671f
2240 Hemochromatosis, hereditary genetic counseling, 676
as complication of factor VIII replacement, Hereditary hemorrhagic telangiectasia in infants, 674
2126 (HHT), 629, 1986, 1987, 2108– inheritance of, 673
cryoglobulinemia and, 2097 2109, 2109f, 2172 laboratory features, 670f, 675
immune thrombocytopenia and, 2009 Hereditary hydrocytosis, 682t, 683–684 molecular determinants of severity, 673
lymphomas and, 1574, 1664, 1666 Hereditary methemoglobinuria, 793. See nonerythroid manifestations, 675
porphyria cutanea tarda and, 906, 909 also Cytochrome b reductase pregnancy and, 674
5
transfusion-related, 518, 1410, 2370t deficiency secondary membrane defects in,
Waldenström macroglobulinemia and, Hereditary nonspherocytic hemolytic 672–673
1711 anemia, 690 spleen in, 673
Hepatocyte growth factor, 1449 course and prognosis, 712 therapy/prognosis, 676
Hepatocytes, 551 differential diagnosis, 711 Hereditary stomatocytosis syndromes,
Hepatocyte transplantation, 452 enzyme abnormalities in, 700t 682–683, 682t
Hepatoerythropoietic porphyria, 889, 890t, G6PD variants and, 702 cryohydrocytosis, 684
891t, 905, 906. See also Porphyria laboratory features, 710–711 familial deficiency of high-density
cutanea tarda (PCT) pyruvate kinase deficiency in, 690, 709 lipoproteins, 684
Hepatoma, erythrocytosis and, 879 therapy, 711–712 hereditary stomatocytosis/hydrocytosis,
Hepatosplenic T-cell lymphoma (HSTCL), Hereditary orotic aciduria, 608 683–684
185t, 1498t, 1567, 1701 Hereditary persistence of fetal hemoglobin hereditary xerocytosis, 683
Hepatosplenomegaly (HPFH) intermediate syndromes, 682t
in alloimmune hemolytic disease of the deletion forms, 726, 734f, 735, 736t laboratory features, 670f
fetus and newborn, 848 δβ type, 748–749 pathophysiology, 473
in NK-cell leukemia, 1566 heterocellular, 749 Rh-deficiency syndrome, 684
in primary myelofibrosis, 1324 molecular basis, 735–736, 736t, 737f Hereditary thrombophilia, 2221–2229
Hepcidin nondeletion forms, 726, 735–736, 736t, 749 antithrombin deficiency. See Antithrombin
in iron regulation, 551, 551f, 552, 620–622, pathophysiology, 741 (AT) deficiency
620f, 621t Hereditary pyropoikilocytosis (HPP), arterial thromboembolic disease risk in,
in myeloma, 1740 677–680 2226–2227
Hepcidin (HAMP) mutations, 642 clinical features, 679 cardiovascular disease and, 2221
Hephaestin, 621t definition and history, 677 classification, 2222
Heptahelical receptors. See G-protein– differential diagnosis, 679 clinical implications of testing for, 2225,
coupled receptors (GPCRs) epidemiology, 677 2227–2229, 2228t
Herald state of leukemia, 1342 erythrocyte membrane protein defects, factor V Leiden. See Factor V Leiden/
Herbicides, lymphomas and, 1571, 1572– 677–678 factor V G1691A
1573 etiology and pathogenesis, 677 history, 2222
Hereditary coproporphyria, 889, 890t, 891t, in infancy, 679 hyperhomocysteinemia. See
904–905 laboratory features, 677f, 679 Hyperhomocysteinemia
Hereditary elliptocytosis (HE), 677–680 molecular determinants of clinical severity, persistent elevated factor VIII. See Factor
clinical features, 679 678–679 VIII, increased levels
definition and history, 677 therapy and prognosis, 679–680 pregnancy complications and, 2221, 2225t,
differential diagnosis, 679 Hereditary spherocytosis (HS), 669–676 2227, 2228t, 2229
epidemiology, 677 vs. autoimmune hemolytic anemia, 835 prevalence, 2222t
erythrocyte membrane protein defects, clinical features/classification, 673–674, protein C deficiency. See Protein C
677–678 673t deficiency
etiology and pathogenesis, 473, 677 complications, 674–675 protein S deficiency. See Protein S
in infancy, 679 definition and history, 669 deficiency
inheritance, 679 differential diagnosis, 675–676 prothrombin G20210A. See Prothrombin
laboratory features, 670f, 679 epidemiology, 669 G20210A

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