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2446           Index                                                                                                                                                                                               Index         2447




               Hodgkin lymphoma, HIV-associated (Cont.):   HPFH. See Hereditary persistence of fetal   hematopoietic cell transplantation for,
                   hematopoietic cell transplantation for,   hemoglobin (HPFH)                 1248
                       1248                         HPP. See Hereditary pyropoikilocytosis   hemophagocytic syndrome, 1250–1251,
                   incidence, 1243, 1247, 1605             (HPP)                               1250t
                 laboratory features, 1610          HPRT (hypoxanthine                    Hodgkin lymphoma. See Hodgkin
                   histopathology, 1497t, 1599–1601,       phosphoribosyltransferase), 1439    lymphoma, HIV-associated
                       1600f, 1601f                 HPS (Hermansky-Pudlak syndrome). See   incidence, 1243, 1244f, 1571
                   monocytosis, 1097                       Hermansky-Pudlak syndrome      Kaposi sarcoma–associated
                   radiographic, 1608, 1608f               (HPS)                               herpesvirus-associated
                 nodular lymphocyte-predominant     HR (homologous recombination), 453         inflammatory cytokine syndrome,
                   differential diagnosis, 1609     HRE (hypoxia-response element), 484, 486   1250
                   immunophenotype, 1497t, 1604t    HS. See Hereditary spherocytosis (HS)  plasmablastic lymphoma, 1246
                   laboratory features, 1497t, 1600–1601,   HS40, 730                     primary central nervous system
                       1600f, 1601f, 1609           HSCs. See Hematopoietic stem cells (HSCs)  lymphoma, 1244f, 1246, 1579
                   treatment, 1616                  HSCT. See Hematopoietic cell transplantation   primary effusion lymphoma, 1246–1247,
                 in pregnancy, 123–124                     (HCT)                               1496t
                 staging, 1609–1610, 1610t          HSP (Henoch-Schönlein purpura), 1162,   prognosis, 1247
                 therapy, 1610–1616                        2103–2104, 2103f             Human immunodeficiency virus (HIV)
                   advanced disease, 1613–1615      Hsp90, 219, 487                            infection
                   chemotherapy regimens, 1612t     HSTCL (hepatosplenic T-cell lymphoma),   anemia in
                   clinical trials, 1615t                  185t, 1498t, 1567, 1701          causes, 1251–1252, 1251t
                   complications, 1617–1618         HSV. See under Herpes simplex virus (HSV)  incidence, 1251
                   favorable, limited-stage disease,    HSV-TK (herpes simplex virus thymidine   medication-related, 1252
                       1611–1613, 1612t                    kinase), 440                     treatment, 1252
                   hematopoietic cell transplantation,    HTLV. See Human T lymphotropic virus   antiphospholipid antibodies and, 2234,
                       366                                 (human T-cell leukemia/lymphoma     2241
                   historical perspective, 1610–1611       virus) (HTLV)-1                aplastic anemia in, 518
                   nodular lymphocyte predominant   HtrA2, 208                            cardiovascular disease and, 2281
                       disease, 1616                huCRIg(L), 1053f                      CCR5 expression in, 440, 1240
                   recurrent disease, 1616          huCRIg(S), 1053f                      clinical features, 1240–1242
                   unfavorable limited-stage disease, 1613  Human androgen-receptor gene   as complication of factor VIII replacement,
               Holotranscobalamin, 593, 603                (HUMARA), 883                       2126
               Holotransferrin, 622, 623f           Human Genome Project, 152             disease progression, 1240–1242
               Homocysteine, 598–599, 603, 1976, 2222  Human herpes virus (HHV)-6         epidemiology and transmission,
               Homocystinuria (cbIE and cbIG), 607, 607t,   aplastic anemia and, 518           1239–1240
                       2222                           mononucleosis syndrome and, 1268    lymphocytopenia in, 1204
               Homogenous nucleation, 763             T-cell therapy, 412                 malignancies in. See Human
               Homologous desensitization, 1877     Human herpes virus (HHV)-8                 immunodeficiency virus
               Homologous recombination (HR), 453     in Castleman disease, 1249–1250, 1496t   (HIV)–associated malignancies
               Horn cells. See Keratocytes (horn cells)  epidemiology, 1573–1574          mannose-binding lectin deficiency and,
               Host defense                           in Kaposi sarcoma, 1573                  1017
                 basophils and mast cells in, 969–970  in primary effusion lymphoma,      mast cells in, 970, 972
                 iron deficiency and, 631–632              1246–1247, 1574                megaloblastic anemia in, 605
               Howell-Jolly bodies                  Human immunodeficiency virus (HIV)-1,   mononucleosis syndrome in, 1268
                 characteristics, 467–468, 467f            1239                           neutropenia in, 997, 1254
                 in hyposplenism, 868–869, 869f     Human immunodeficiency virus (HIV)-2,   opportunistic infections in, 1240–1241,
                 in megaloblastic anemia, 594              1239                                1241t
               HOX11, 863, 1508t, 1513t             Human immunodeficiency virus          pathogenesis, 1240
               HOX11L2, 1508t                              (HIV)–associated malignancies,   persistent B19 parvovirus infection with
               HOXA9, 234t, 266, 268                       1500t                               red cell aplasia in, 543, 544, 545f,
               HOXB4, 266, 268                        Burkitt lymphoma, 187, 1244f, 1245, 1247,   1251–1252
               Hox family of transcription factors, 262    1672, 1676                     porphyria cutanea tarda in, 906–907
               Hoyeraal-Hreidarsson syndrome, 531     Castleman disease, 1249–1250        in pregnancy, 1269
               HPAs. See Human platelet antigens (HPAs)  diffuse large B-cell lymphoma, 187,    prevention and cure, 1242–1243
               5-HPETE, 289                                1243–1245, 1244f, 1247, 1571   primary, 1240, 1268
               12-HPETE, 1877                         etiology, 1573                      staging, 1240–1241, 1240t








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