Page 2471 - Williams Hematology ( PDFDrive )

2442 Index Index 2443

Hemoglobin F. See also Hereditary differential diagnosis, 637 stress reticulocytes in, 482f
persistence of fetal hemoglobin drug-induced, 553 unstable hemoglobins and, 781–782
(HPFH) of the fetus and newborn. See Alloimmune Hemolytic uremic syndrome (HUS)
structure, 728 hemolytic disease of the fetus and atypical, 1932, 1953, 2259–2261, 2259t
switch to adult hemoglobin, 730 newborn (HDFN) differential diagnosis, 837
synthesis, 101, 101t, 102f in G6PD deficiency, 706–707, 707t Shiga toxin E. coli-associated, 132.,
in thalassemias, 741 heart valve, 804–806, 805f, 805t 2258–2259
therapy to increase, 753, 774–775, 775t in hereditary spherocytosis, 674 therapy, 429t
types, 101, 101t intravascular, 631 Hemopexin, 293, 499, 500f
Hemoglobin G Philadelphia , 778 mechanisms Hemophagocytic lymphohistiocytosis (HLH)
Hemoglobin G Philadelphia H disease, 751 chemical and physical agents, Chédiak-Higashi syndrome and, 1018
Hemoglobin H, 726 809–810 clinical features, 1114
Hemoglobin Hasharon H disease, 751 enzyme deficiencies, 706–708, 707t definition and history, 1113
Hemoglobin H disease megaloblastic anemia and, 597 diagnostic criteria, 1114, 1114t
clinical features, 745 in sickle cell disease, 764 differential diagnosis, 1115
differential diagnosis, 637 Hemolytic anemia epidemiology, 1113
laboratory features, 747, 747f alloimmune, 836 etiology and pathogenesis, 1101,
molecular basis, 739 autoimmune. See Autoimmune hemolytic 1113–1114
in myelodysplastic syndromes, 1353 anemia histopathology, 1102t
treatment, 753 cold agglutinin, 1790 immune deficiencies associated with, 304,
Hemoglobin H inclusions, 467f, 468 Donath-Landsteiner, 824 1114
Hemoglobin Kansas , 789, 794t drug-induced immune, 708, 708t, 826t laboratory features, 1114f, 1115
Hemoglobin Kenya, 735 classification, 824t, 825 macrophage activation syndrome in,
Hemoglobin Köln , 762 clinical features, 832 1115–1116
Hemoglobin Köln disease, 637 course and prognosis, 840 therapy, 1115
Hemoglobin Lepore, 733–734, 735f, 748 differential diagnosis, 837 Hemophagocytic syndrome
Hemoglobin Lincoln Park, 734 epidemiology, 827 Epstein-Barr virus mononucleosis and,
Hemoglobin M. See also Methemoglobinemia etiology, 827 1265
clinical features, 792 laboratory features, 832 HIV-associated, 1250–1251, 1251t
history, 789 pathogenesis, 825, 825f, 829–831, 830t Hemophilia A (classic hemophilia, factor
laboratory features, 792, 793f serologic features, 836 VIII deficiency), 1985, 2113–2126
properties, 782, 790–791, 791t therapy, 839–840 acquired, 2183–2186
Hemoglobin M Boston , 791t folate deficiency in, 598 clinical features, 2116–2120, 2116t
Hemoglobin M Fort Ripley , 791t fragmentation, 801–806 bleeding following circumcision, 1988
Hemoglobin M Hyde Park , 791t, 792 cancer-associated microangiopathic, dental and surgical bleeding, 2120
Hemoglobin M Iwate , 791t 803, 803–804 gene mutations, 441
Hemoglobin Miyada, 734 heart valve hemolysis, 804–806 gene therapy, 442
Hemoglobin M Milwaukee , 791, 791t Kasabach-Merritt phenomenon, 806 hemarthroses, 2116–2117, 2117f, 2118f
Hemoglobin M Osaka , 791t march hemoglobinuria, 806 hematomas, 2117–2118, 2119f
Hemoglobin M Saskatoon , 791t, 792 preeclampsia/eclampsia and HELLP hematuria, 2119
Hemoglobinopathies, 725 syndrome, 801–803. See also mucous membrane hemorrhage, 2120
in pregnancy, 125–126 HELLP syndrome neurologic, 2119–2120
sickle cell disease. See Sickle cell disease hereditary nonspherocytic. See Hereditary pseudotumors, 2119, 2120f
thalassemias. See Thalassemias nonspherocytic hemolytic anemia course and prognosis, 2124–2126, 2124t,
Hemoglobin P-Nilotic, 734 infection-related, 815–820, 816t 2125t
Hemoglobin QH disease, 751 babesiosis, 429t, 432, 817f, 818–819 anti-factor VIII antibodies and,
Hemoglobin S, 762, 763–764, 765f. See also bartonellosis, 818, 997 2124–2126, 2124t, 2125t, 2126t
Sickle cell disease Clostridium perfringens septicemia, 819 infectious complications, 2126
Hemoglobin SC disease, 779f in G6PD deficiency, 708–709 definition and history, 2113–2114
Hemoglobin Seattle , 794t malaria. See Malaria differential diagnosis, 2121
Hemoglobinuria, 631 in newborns, 848. See also Alloimmune etiology and pathogenesis, 2114
Hemoglobin Zurich , 762, 795 hemolytic disease of the fetus and gene mutations, 2114–2116, 2114f, 2115f
Hemojuvelin (HJV), 566, 621, 621t, 642 newborn (HDFN) laboratory features, 2120–2121
Hemojuvelin (HJV) mutations, 642 in paroxysmal nocturnal hemoglobinuria, pregnancy and, 121
Hemolysins, 823, 829 571, 573f prenatal diagnosis and carrier detection,
Hemolysis/hemolytic disease in Rosai-Dorfman disease, 1113 121, 2116

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