Page 2486 - Williams Hematology ( PDFDrive )

2457
2456 Index Index 2457

Kininogen, high-molecular-weight, 1916t, activity, 692t Late hemorrhagic disease of the newborn,
1929, 2121 in Burkitt lymphoma, 1245 109
Kinins, 286t, 289 in chronic lymphocytic leukemia, 1532, Latent membrane protein 1 (LMP1), 1606
KIRs (killer cell immunoglobulin-like 1532t LCAD (long-chain acyl coenzyme A
receptors), 1190, 1401, 1461, 1565 in chronic myelogenous leukemia, 1448 dehydrogenase) deficiency, 2211
KIT in diffuse large B-cell lymphoma, 1632 LCDD (light chain deposition disease), 1744,
in acute myelogenous leukemia, 181, 181t, in glucose metabolism, 692, 696 1760
227t, 1376 in HELLP syndrome, 802 LCMV (lymphocytic choriomeningitis virus),
imatinib sensitivity and, 1279 in megaloblastic anemia, 597 1192
in mast cell disorders, 965, 973, 976, 977 in myeloma, 1716 LCR (locus control region), 730
in primary myelofibrosis, 1321 in paroxysmal nocturnal hemoglobinuria, LDH. See Lactate dehydrogenase (LDH)
Klebsiella infections, 383, 1030. See also 575 Lead poisoning, 811
Bacterial infections Lactoferrin, 284t, 285, 1012t, 1013 Lectin-containing receptors, 1870–1871
Kleihauer-Betke test, 859, 859f Lactoferrin receptors, 1058t Lectins. See Selectins (lectins)
KLF1/KLF1, 568, 730, 2337 LAD. See Leukocyte adhesion deficiency LEF1, 1643
KLH (keyhole limpet hemocyanin), 423, λ gene, 1168 Legionella, 1062, 1064f, 1066f
423f, 424f, 1648 λ light chains, 1163 Legionnaire disease, 304
KLHL6, 1529 Lamellipodium, 1005 Leg ulcers, 6, 8, 771–772
KM (κ light-chain) allotypes, 1170, 1741 Laminin, 63, 267, 1846t, 1865 Leishmania, 1062, 1064f
KMD6A, 1346t Laminin receptor. See Integrin α β Lenalidomide, 333–335
6 1
KMS (Kasabach-Merritt syndrome), 806, LAMP-1 (CD107a), 1873 for acute myelogenous leukemia, 1404
2014–2015, 2317t, 2318 LAMP-2 (CD107b), 1873 adverse effects, 334–335, 1741, 1752,
KMT2A, 183 LAMP-3. See CD63 1756–1757
KMT2A/MLL, 176f Lan blood group, 2332t for AL amyloidosis, 1761, 1780–1781
KMT2D (MLL2), 1644 Landsteiner-Wiener blood group, 2331t for chronic lymphocytic leukemia,
KMTA/AFF1 (MLL-AF4), 1507 Langerhans cell histiocytosis 1538–1539
Knockout animal models, 153 adult, 1108–1109 clinical use, 334
Knops blood group/antigens, 2332t, 2337, clinical features for diffuse large B-cell lymphoma, 1631
2346t multisystem, 1104–1105, 1105f for mantle cell lymphoma, 1658, 1659t,
Koilonychia, 8, 632 single-site, 1103–1104, 1103f 1660t
Kostmann syndrome, 983, 992–993, 993f consequences and late effects of treatment, mechanism of action, 333–334, 1192
a
Kp /Js blood group, 2335t 1107–1108 for myelodysplastic syndromes, 1359
a
KRAS (K-RAS) course and prognosis, 1107 for myeloma, 364, 365f, 1750–1751, 1752,
in acute myelogenous leukemia, 1376, differential diagnosis, 1106 1752t, 1753, 1753t, 1754
1384t epidemiology and inheritance, 1102–1103 pharmacology, 334
in chronic myelomonocytic leukemia, etiology and pathogenesis, 1101, 1103 for primary myelofibrosis, 1329
1468 histopathology, 1102t structure, 333f
in juvenile myelomonocytic leukemia, history, 1100 Lentiviral vectors, 439, 443
1468t laboratory features, 1105–1106, 1105f Lepirudin
in myelodysplastic syndromes, 1346t treatment, 1106–1107, 1106t for heparin-induced thrombocytopenia,
in myeloma, 188, 233t, 1709, 1737, 1759, Langerhans cells, 310, 1078, 1078f, 1082, 2030
1760 1101 pharmacology, 399
Kruppel-like factor (KLF1), 568, 730, 2337 Langerhans cell sarcomas, 1110 removal from market, 399
Ku70, 1167 Lansoprazole, megaloblastic anemia and, for unstable angina, 2296
Ku80, 1167 606t Leptocytes, 473t, 474f
Kwashiorkor, 654 Large granular lymphocytic leukemia Leptomeningeal myelomatosis, 1746
Kx blood group/antigens, 2332t, 2337, 2342 (LGLL), 1352, 1499t, 1563. See also Lesch-Nyhan syndrome, 608
Kyphoplasty, 1756 T-cell large granular lymphocytic Letterer-Siwe disease. See Langerhans cell
leukemia (T-LGLL) histiocytosis
L Large granular lymphocytosis, 1189, LEU7 (CD57), 1528
L444P, 1123, 1123t 1202–1203 Leu33Pro, 1851
LA (lupus anticoagulants), 2101f, 2186, 2233, Larval myeloma, 1725 Leucine-rich repeat glycoprotein receptors,
2243 Lassitude, history of, 4 1858–1859t, 1865–1868
Labile iron pool, 618 Lasthénie de Ferjol syndrome, 630 Leucovorin, 320–321, 584
Lactate dehydrogenase (LDH) LAT (linker of activation of T cells), 1144, Leukämie, 1438
abnormalities, 701t 1178 Leukapheresis, 1450, 1540, 2368

Kaushansky_index_p2393-2506.indd 2457 9/21/15 3:22 PM