Page 2487 - Williams Hematology ( PDFDrive )

2458 Index Index 2459

Leukemia. See also individual types in children, 15t LGLL (large granular lymphocytic leukemia),
α-thalassemia and, 739 in chronic myelogenous leukemia, 1445, 1563. See also T-cell large granular
associated with basophilia, 971–972, 972t 1445f lymphocytic leukemia (T-LGLL)
B-cell, 1494t in newborn, 105, 105t LGMN, 1643
cell growth and metabolism in, 197–198, in primary myelofibrosis, 1326 LGP2, 300
198f reference ranges, 18t Lhermitte sign, 1618
cellular therapy, 413–414 Leukocyte differential, 16–17 Lidocaine, toxic methemoglobinemia and,
disseminated intravascular coagulation Leukocyte function antigen. See under LFA 789
and, 2207 Leukocyte integrin (β ) subfamily, 1054 Life span, 131–132
2
mast cell, 978 Leukocytes Li-Fraumeni syndrome, 1575t
platelet function and, 2081–2082 in acute inflammation, 280–284 LIGHT (tumor necrosis factor receptor
during pregnancy, 124 adhesion and transmigration, 280–283, superfamily member 14), 1873
T-cell, 1498t, 1571, 1573 282f, 282t Light chain deposition disease (LCDD), 1744,
Leukemia-associated proteins, 414 chemotaxis and activation, 283–284, 1760
Leukemia inhibitory factor, 1821 284t Light chain glomerulonephropathy, 1744
Leukemia stem cell, 1376 artifacts, 23 Light chains, immunoglobulin. See
Leukemic blast cells automated analysis, 16–17 Immunoglobulin (Ig) light chains
in acute myelogenous leukemia, 1381 cellular homing and, 68–69 Light-chain vasculopathy, 2099
in clonal myeloid disorder classification, donor infusions of, 1400–1401 Lindane, 517
1277 fetal liver, 100 Linezolid, 384, 385, 388t
extramedullary tumors and, 1285 inclusions, 23 Linkage analysis, 151–152, 151f
hyperleukocytic syndromes and, interactions with endothelial cells, Linker of activation of T cells (LAT), 1144,
1285–1286, 1286t 1977–1978, 1977t, 1979 1178
procoagulant and fibrinolytic activator interactions with platelets, 1829–1834, Lipid granulomatosis. See Erdheim-Chester
release and, 1285 1830–1831f, 1852f, 1855–1856, disease
Leukemic reticuloendotheliosis, 1553. See 1857f, 1978–1979 Lipid mediators, 952, 1878
also Hairy cell leukemia (HCL) iron deficiency and, 633 Lipid rafts, 662, 1836
Leukemic transformation levels of, in older persons, 134 Lipids
in clonal myeloid diseases, 1280–1281 in marrow infiltration, 659f disseminated intravascular coagulation
in polycythemia vera, 1295 morphology, 22–23 and, 2203
in thrombocythemia, 1310 in newborn, 105 inflammatory, 288–289
Leukemoid reaction, 999 nucleotides in, 935t membrane. See Membrane lipids
Leukocytapheresis, 429t, 433 in polycythemia vera, 1295 in neutrophils, 935, 935t
Leukocyte adhesion deficiency type 1 release, 71 peroxidation, 2287
(LAD-1) response, 247 Lipid storage diseases, 1121–1130
clinical features, 1019t, 1021t, 1022–1023 types, 20f catabolic pathways of glycosphingolipids
definition and history, 1021–1022 Leukocytoclastic vasculitis, 2096f in, 1122f
differential diagnosis, 1023–1024 Leukocytosis, 43–44, 997. See also definition, 1121
etiology and pathogenesis, 1019t, 1022 Neutrophilia Gaucher disease. See Gaucher disease
gene mutations, 1021t Leukodystrophies, 439 Niemann-Pick disease. See Niemann-Pick
laboratory features, 1021t, 1023, 1023f Leukoerythroblastic reaction, 657, 659f disease
therapy, course, and prognosis, 1024 Leukolysin, 1012t, 1014 Lipopolysaccharide (LPS), 294, 298, 2203
Leukocyte adhesion deficiency type 2 Leukomethylene blue, 793 Lipopolysaccharide responsive beige-like
(LAD-2), 1019t, 1021t, 1023–1024, Leukopenia, 991. See also Neutropenia anchor (LRBA) deficiency, 1216
2343 Leukoreduction, for platelet transfusion, 2388 Lipoprotein(a), 1287, 1976
Leukocyte adhesion deficiency type 3 Leukosialin, 1873 Lipoprotein-associated coagulation inhibitor.
(LAD-3, LAD-1 variant syndrome), Leukotriene B , 283, 952 See Tissue factor pathway inhibitor
4
1019t, 1024, 2060 Leukotrienes, 1830–1831f (TFPI)
Leukocyte antigens, human. See Human Levofloxacin, 387t Lipoprotein phospholipase A , 2286
2
leukocyte antigens (HLAs) Lewis blood group/antigens, 104, 2331t, Liposomal amphotericin-B, 385, 387t
Leukocyte common antigen. See CD45 2334t, 2337, 2340, 2344t Lipoxins, 289, 1857f
(T200) LFA-1. See CD11a (LFA-1) Lipoxygenases, 2287
Leukocyte count, 16 LFA-2 (CD2), 1185, 1185f Listeria, 1062, 1064f
in acute lymphoblastic leukemia, 1510, LFA-3 (CD58), 1184, 1185, 1978 Listeria infection, 383. See also Bacterial
1510t LFA (lymphocyte function-associated) infections
in acute myelogenous leukemia, 1381 glycoproteins, 1184–1185, 1185f Livedoid reticularis, 2240, 2298

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