Page 2485 - Williams Hematology ( PDFDrive )

2456 Index Index 2457

Isocitrate dehydrogenase (IDH), 170, 198, in myelodysplastic syndromes, 181t, 1352 κ light-chain (KM) allotypes, 1170, 1741
199f, 337, 337f in polycythemia vera, 178, 1292, κ light-chain gene complex, 1165f, 1167f
Isocitrate dehydrogenase (IDH) inhibitors, 1295–1296, 1312, 1312f, 1313f Karnovsky scale, 4t
337 in primary myelofibrosis, 1320–1321 Karyotype, 175t
Isofagomine tartrate, 1128 JAK3, 232t, 233t Kasabach-Merritt syndrome (KMS), 806,
Isoniazid, for tuberculosis, 386 JAK3 deficiency, 1214t, 1217–1218 2014–2015, 2317t, 2318
ISWI-(imitation SWI) remodelers, 166, 166f JAM. See under Junctional adhesion molecule Kawasaki disease, neutropenia and, 997
ITAMs. See Immunoreceptor tyrosine-based (JAM) KEAP1, 196
activation motifs (ITAMs) Jamshidi biopsy instrument, 28, 28f, 29 KEL, 851
ITCH E3 ubiquitin protein ligase deficiency, Janus kinase (JAK), 248, 249, 251f, 252 Kell blood group
1224 Janus kinase (JAK)-2, 250, 485, 486f, 932 antibodies, 2345t
Itching. See Pruritus/itching Janus kinase (JAK)-3, 1154, 1217–1218 antigens, 2335t, 2337
ITF4 (MUM1), 234t Janus kinase (JAK) inhibitors, 341–342 characteristics, 2331t, 2334t
ITGB3, 1851 Janus kinase (JAK)/STAT pathway, 1606 disease association, 2331t, 2340
ITIM (immunoreceptor tyrosine inhibitory Jaundice fetal expression, 104
motif), 1184, 1190, 1868, 1884 in alloimmune hemolytic disease of the frequency, 2334t
ITK, 1643 fetus and newborn, 848–849 genetics, 2339
ITK-SYK, 1696 eye, 8 in hemolytic disease of the fetus and
131 I-tositumomab history of, 6 newborn, 851, 851f
for diffuse large B-cell lymphoma, 1632 neonatal, 707, 709 phenotypes, 2334t
for follicular lymphoma, 1647 skin, 7–8 in pregnancy, 853–854
ITP. See Immune thrombocytopenia (ITP) JC polyomavirus infection, 1240, 1536 variation in expression, 2337
Itraconazole, 387t, 389 Jk(a-b-) phenotype, 2343 XK protein, 681. See also McLeod
ITSM (immunoreceptor tyrosine-based J C gene segments, 1170 phenotype
λ
λ
switch motif), 1868 JMH blood group/antigens, 2337, 2346t Keratocytes (horn cells), 473f, 473t, 474f
IVIg. See Intravenous immunoglobulin JNK (c-Jun N-terminal kinase), 249, 298, Kernicterus, 849, 858
(IVIg) 1178 Ketanserin, 2079
Ixazomib, 1754 Job syndrome. See Hyperimmunoglobulin E α-Ketoglutarate. See 2-Oxoglutarate (2OG)
Ixodes dammini, 2311 syndrome (HIES) Ketotifen, for mastocytosis, 976
John Milton Hagen blood group, 2332t Ketron-Goodman variant, pagetoid
J Joints, examination of, 9. See also reticulosis, 1684
Jagged ligand, 1824 Hemarthroses Keyhole limpet hemocyanin (KLH), 423,
JAK. See under Janus kinase (JAK) JR blood group, 2332t 423f, 424f, 1648
JAK1, 232t, 233t, 235t Junctional adhesion molecule-3 (JAM-3), Ki-67, 1654
JAK2 1856 KIAA0023, 414
in B-cell acute lymphoblastic leukemia, Junctional adhesion molecule-A (JAM-A), KICS (Kaposi sarcoma–associated
232t, 1508 1870 herpesvirus-associated
in essential thrombocythemia, 228t, 1278 Junctional adhesion molecule-A (JAM-C), inflammatory cytokine syndrome),
in familial thrombocytosis, 1310 1870, 1977t, 1979 1250
in myelodysplastic syndromes, 228t c-Jun N-terminal kinase (JNK), 249, 298, Kidd blood group/antigens, 2331t, 2335t,
in myelofibrosis, 228t, 1278 1178 2337, 2340, 2345t
in polycythemia vera, 228t, 1278, 1450 Juvenile myelomonocytic leukemia, 1096, Kidney disease/dysfunction. See Renal
in primary myelofibrosis, 1319, 1450 1468t, 1470–1471 disease/dysfunction
JAK2 exon 12 mutations, 1296 Juvenile rheumatoid arthritis, 1090–1091, Kidney transplantation. See Renal
JAK2 inhibitors 1513 transplantation
for essential thrombocythemia, 1314 Juvenile xanthogranuloma (JXG), 1101, KIF23, 568
for polycythemia vera, 1300 1102t, 1111–1112 Killer cell immunoglobulin-like receptors
for primary myelofibrosis, 1328–1329, (KIRs), 1190, 1401, 1461, 1565
1329t K Kinases
JAK2 V617F Kallikrein, 286t, 289 cyclin-dependent. See Cyclin-dependent
in acute myelogenous leukemia, 181t Kaolin clotting time, 2243 kinases (cdks)
in chronic neutrophilic leukemia, 1279, Kaposi-like hemangioendothelioma, 2014 Janus. See under Janus kinase (JAK)
1468t, 1472 Kaposi sarcoma, 1239, 1250, 1573 Kindlin, 1884
in essential thrombocythemia, 1307, 1308f, Kaposi sarcoma–associated herpesvirus- Kindlin-3 deficiency (LAD; LAD-1 variant;
1311, 1312, 1312f, 1315 associated inflammatory cytokine integrin activation deficiency),
in hypereosinophilic syndrome, 958 syndrome (KICS), 1250 1019t, 1024, 2060

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