Page 2489 - Williams Hematology ( PDFDrive )

2460 Index Index 2461

Lymphocytes, disorders (Cont.): pertussis, 1202 Hodgkin lymphoma treatment and, 1617
combined T-and B-cell, 1197 stress lymphocytosis, 1204 indolent, 1501t, 1570
natural killer cell, 1197 Lymphoid fibrosis, 1553. See also Hairy cell marrow findings, 31–32
T lymphocyte, 1195–1197 leukemia (HCL) monocytosis and, 1097
infants, 108–109, 109t Lymphoid-myeloid primed progenitor in pregnancy, 124
infusions from donor, in allogenic (LMPP), 61, 1152f, 1153 response assessment, 1570, 1578–1579,
hematopoietic cell transplantation, Lymphoid progenitors, 269–270 1579t, 1580t
359, 373 functional characterization, 1154 secondary acute myelogenous leukemia
large granular, 23 human, 1153 and, 1407
marrow, 32t, 35 murine, 1153 staging, 1570, 1577–1579, 1577f, 1578t,
in mycosis fungoides, 1683f thymic, 1154 1579t
in myelodysplastic syndromes, 1353 Lymphoid tissues, 85 vaccine therapy for, 423, 423f, 424f
in newborn, 105t lymph nodes. See Lymph nodes Lymphomatoid granulomatosis, 1635
precursors, increased apoptosis of, 1217 mucosa-associated, 93–94 Lymphomatoid papulosis, 1499t, 1688–1689,
reactive, 23 Peyer patches, 94, 94f 1688t
reference ranges, 15t, 18t spleen. See Spleen Lymphomatous polyposis, 1593, 1593f
release, 72 thymus. See Thymus Lymphopenia, consultative approach to, 42
structure, 1137–1140 tonsils, 94, 1081f Lymphoplasmacytic lymphoma (LPL).
changes associated with activation, Lymphokines, 208–209 See also Waldenström
1138f, 1139–1140, 1140f Lymphomas, 1569–1583. See also individual macroglobulinemia (WM)
cytomatrix, 1144–1145 types chromosomal abnormalities, 184t, 1494t
definition and history, 1137 aggressive, 1501t definition, 1785
microscopy and histochemistry, 966f, cell growth and metabolism in, 199–200 differential diagnosis, 1667, 1668
1137–1139, 1138f, 1139f chromosomal abnormalities, 184–185t, gene mutations, 184t, 234t, 1494t
organelles, 1145 187–188, 224–225t, 1576–1577 laboratory features, 1592–1593, 1593f
types, 20f, 23 vs. chronic lymphocytic leukemia, 1543 Lymphopoiesis, 1149–1156, 1282f
Lymphocytic choriomeningitis virus classification, 1493–1501, 1587–1589, differentiation pathways, 1151–1154, 1152f
(LCMV), 1192 1588t functional characterization of
Lymphocytopenia, 1204–1206 clinical features, 1493, 1577 progenitors in, 74.
acquired, 1204–1206, 1205t abnormal immunoglobulin production, human lymphoid progenitors in, 1153
iatrogenic, 1205–1206 1501 murine lymphoid progenitors in, 1153
in infectious diseases, 1204–1205 lymphokine-induced disorders, 1502 thymic progenitors in, 1154
nutritional or dietary, 1206 marrow and tissue infiltration, 1502 fetal, 101
in systemic disease, 1206 metabolic signs, 1502 neonatal, 108–109
definition, 1204 systemic symptoms, 1502 during prenatal development, 1149–1151,
idiopathic CD4+ T, 1206 definition and history, 1569–1570 1150f
inherited causes, 1204, 1205t diagnosis, 1590–1592, 1591t regulation, 1154–1156
Lymphocytosis, 1199–1204 early precursor lesions, 1501 Lymphosarcoma, 1569, 1603
causes, 1200t epidemiology, 1570–1571, 1570f, 1571f Lyso-glucosylsphingosine, 1126
consultative approach to, 44 etiology and pathogenesis, 1571–1576 Lysophosphatidic acid (LPA), 1878
definition, 1199 autoimmunity, 1574–1575 Lysosomal granule constituents, 286t, 287
primary, 1199–1202 environmental factors, 1571, 1572–1573 Lysosomal proteases, 284t
monoclonal B-cell lymphocytosis, histopathologic heterogeneity, Lysosomal storage diseases. See Lipid storage
1199–1200, 1201t, 1542–1543 1571–1572, 1572t diseases
persistent polyclonal lymphocytosis of B immunosuppression, 1574, 1575t Lysosome-associated membrane proteins. See
lymphocytes, 1200–1202, 1201f infectious agents, 1265, 1573–1574 under LAMP
secondary (reactive), 1202–1204 interaction of environment and Lysosomes, 1145, 1843
acute infection lymphocytosis, 1202, genotype, 1573 Lysozyme, 284t, 1012t, 1014, 1064, 1067t
1203f extranodal involvement, 1502 LYST, 994, 1229, 1843
drug-induced lymphocytosis, gene mutations, 166, 209–210 Lytic state, 403
1203–1204 hematopoietic cell transplantation for, 366
hypersensitivity reactions, 1204 histologic subtypes and frequency of, M
infectious mononucleosis, 1202 1571–1572, 1572t mAbs. See Monoclonal antibodies (mAbs)
large granular lymphocytosis, HIV-associated. See Human MAC, 234t
1202–1203 immunodeficiency virus MAC (membrane attack complex), 572, 572f
persistent lymphocytosis, 1204 (HIV)–associated malignancies Mac-1. See CD11b/CD18 (Mac-1)

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