Page 2519 - Williams Hematology ( PDFDrive )

2490 Index Index 2491

Scramblase, 662 Serotonin transporter (SERT), 1879 SHMT (serine hydroxymethyltransferase),
Scurvy (vitamin C deficiency), 652, 1986, Serpentine receptors. See G-protein–coupled 584–585
2108, 2108f receptors (GPCRs) Shock, in disseminated intravascular
SCYA3, 1632 SERPIN, 1958 coagulation, 2204, 2205t
SDF-1. See CXCL12 (stromal cell-derived SERPINA1, 1699 Short tandem repeats (STRs), 147
factor-1) SERPINA10, 1938 Shoulder pain, history of, 6
Sea-blue histiocytes, 1446 SERPINC1, 1937 SHP1 (hematopoietic cell phosphatase), 253,
Sealing zones, 60 Serpins (serine protease inhibitors), 1145, 485, 486f, 1163
Sec1/Munc18 (SM), 1849 1958, 2304t, 2307–2308 Shwachman-Diamond syndrome, 532,
SEC23B, 564, 567 Serratia marcescens, 106, 1030, 1033 993–994, 1026
Seckel syndrome, 530t, 532 SERT (serotonin transporter), 1879 Sialoadhesin (Siglec1), 1054, 1080, 1081f,
Secondary myelofibrosis, 1325 Serum sickness, 2103, 2103f 1082, 1083f
Secretory protein, 1161 SETBP1, 1348, 1472 Sialomucins, 67t, 68
Secretory vesicles, 930t, 1009 Severe combined immunodeficiency (SCID), Sialophorin, 1873
0
Sedormid purpura, 824 1216–1219 Sickle cell β -thalassemia, 762
Segmented granulocytes, 32t, 34 adenosine deaminase deficiency, 439 Sickle cell β+-thalassemia, 762
Segmented neutrophils, 32t clinical features, 1214t, 1218 Sickle cell disease, 762–776
Selectins (lectins), 66, 67t. See also E-selectin; cytokine-mediated signaling defects and, clinical features and management,
L-selectin; P-selectin 249, 1217–1218 766–773, 767t
counterreceptors, 282t defective signaling through T-cell receptor in anesthesia and surgery, 773
expression, 281 and, 1218 aplastic crises, 767
functions, 1054 definition and history, 1216–1217 avascular necrosis, 771, 771f
ligands, 1057t gene mutations, 1154, 1575t cardiac, 769
structure, 282t increased lymphocyte precursor apoptosis dactylitis, 771
Selenium, 652t in, 1217 hepatobiliary, 772
Selenium deficiency, 654 laboratory features, 1214t, 1218 hyperhemolytic crises, 767
Self-antigens, 2343 lymphomas and, 1575t infection, 773
Self-inactivating (SIN) viral vectors, 437 molecular defects and pathogenesis, 1217, leg ulcers, 771–772
Senicapoc, for sickle cell disease, 777t 1217f nocturnal enuresis, 770–771
Senile purpura, 2107, 2108f neutropenia in, 993 ophthalmic, 772
Sepsis therapy, course, and prognosis, osteomyelitis, septic arthritis, and bone
activated protein C and, 1956 1218–1219 infarction, 771
C. perfringens, 819 gene therapy, 437, 439, 453, 1219 osteopenia and osteoporosis, 771
disseminated intravascular coagulation hematopoietic cell transplantation, 363, pain control, 767–768
and, 2202, 2207 1219 in pregnancy, 772–773
hyposplenism and, 868 X-linked, 437, 439 priapism, 770
postsplenectomy, 2004 Severe-deviation clonal myeloid disorders, pulmonary, 768–769, 769f
during pregnancy, 2211 1276t, 1279–1280 renal failure, 770
transfusion-related, 2376 Sexual history, 7 sequestration crises, 767
tumor necrosis factor -α in, 285 Sézary cell, 1683f, 1684f splenic, 772
SEPT10, 1643 Sézary syndrome (SS), 1498t, 1679, 1683t, stroke, 769–770
Septic arthritis, 771 1684t. See also Cutaneous T-cell vasoocclusive crises, 766–767, 768f
Sequestration crisis, in sickle cell disease, 767 lymphoma (CTCL); Mycosis course and prognosis, 766
Serglycin, 1011 fungoides (MF) epidemiology, 763
Serial analysis by recombinant expression SF1, 1348 G6PD deficiency and, 690
cloning (SEREX), 421 SF3B1, 227t, 231t, 1346t, 1349, 1529 history, 762–763, 762f
Serial analysis of gene expression (SAGE), SFA1. See CD151 hyposplenism and, 868
421 SGI-110, for myelodysplastic syndromes, i antigen and, 2340
Serine hydroxymethyltransferase (SHMT), 1361 inheritance, 149, 149f
584–585 SH2B3 (LNK), 229t, 232t, 233t laboratory features, 762f, 766, 779f
Serine proteases, 1012t, 1013, 1916–1917, Shiga toxin E. coli-associated hemolytic modifiers of disease severity, 773–774
1918t uremic syndrome (STEC-HUS), pathophysiology, 763–766, 764f, 765f
Serosal implants, for primary myelofibrosis, 2255, 2258–2259 abnormal cell adhesiveness, 764–765
1330 Shigella dysenteriae, 2340 activation of coagulation system, 765
Serotonin (5-hydroxytryptamine), 286t, 289, Shigella flexneri, 1066f adenosine signaling, 765–766
1848, 1878–1879 SHIP1, 1443 cellular dehydration, 764

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