Page 2521 - Williams Hematology ( PDFDrive )

2492 Index Index 2493

SMILE regimen, for NK/T-cell lymphoma, in hereditary pyropoikilocytosis, for autoimmune lymphoproliferative
1702 677–678 syndrome, 1224
Smoking. See Cigarette smoking in hereditary spherocytosis, 672 for chronic lymphocytic leukemia, 1539
Smoldering leukemia. See Oligoblastic in erythrocyte membrane skeleton, 666, for chronic myelogenous leukemia, 1459,
myelogenous leukemia (refractory 666f 1467
anemia with excess blasts) in platelets, 1833t, 1837 complications, 2004
Smoldering myeloma, 1708–1709, 1725, structure, 665–666, 665f for Gaucher disease, 1127
1734f, 1761 Spent phase, of polycythemia vera, for Hb C disease, 780
Smooth muscle cells, 2283–2284, 2284f 1294–1295, 1294f for hereditary nonspherocytic hemolytic
Smudge cells, 23, 1530, 1530f Spermidine, 200 anemia, 712
SMZL (splenic marginal zone lymphoma), S-phase checkpoint, 219 for hereditary spherocytosis, 676
1495t, 1557, 1558t, 1666–1667 S-phase promoting factors, 213 for hypersplenism, 866–867
Snake bites, 2209, 2318 Spherocytes, 473 for immune thrombocytopenia, 2003, 2004
Snake venoms, 970 abnormal, 671f. See also Hereditary lymphocytosis following, 1204
SNAP-23 (soluble N-ethylmaleimide- spherocytosis (HS) management following, 869
sensitive factor) attachment in autoimmune hemolytic anemia, 832 for mastocytosis, 978
protein-23, 926, 1849 characteristics, 21, 472t, 474f minimally invasive, 2004
SNARE (SNAP receptor), 953, 1016–1017, diseases associated with, 472t monocytosis following, 1097
1849 Spherostomatocyte, 472f, 472t for paroxysmal nocturnal hemoglobinuria,
S-nitroshemoglobin (SNO-Hgb), 796, 796f Sphingomyelin, 662 579
SNP (single nucleotide polymorphism), 147, Sphingomyelinase, 1129 for polycythemia vera, 1301
174 Sphingomyelinase D, 809 for primary myelofibrosis, 1330
SOCS1, 236t Sphingosine, 1956 for sequestration crisis, 767
SOCS3 (CIS3), 485, 486f Sphingosphine-1-phosphate (S1P), 1857, for splenic marginal zone lymphoma, 1667
SOCS (suppressors of cytokine signaling) 1878 for T-cell large granular lymphocytic
proteins, 253, 298 Spi-1. See PU.1 leukemia, 1567
SOD (superoxide dismutase), 196, 286, 692t, Spider bites, 809, 2102 for thrombocytopenia, 2008
698 Spider telangiectasia, 2098f for thrombotic thrombocytopenic
SOD1, 698 Spinal cord compression, 1746–1747, 1748, purpura, 2256
Sodium chlorate, 810 1749f for warm-antibody autoimmune hemolytic
Sodium citrate, 1996 Spinal cord injury, 451–452 anemia, 838
Sodium phenyl butyrate, 775 Spindle-pole body duplication checkpoint, for Wiskott-Aldrich syndrome, 2060
Solitary plasmacytoma, 1733, 1760 213 Splenic diffuse red pulp small B-cell
Soluble NSF (N-ethylmaleimide-sensitive Spleen, 87–91 lymphoma, 1495t, 1557, 1558t
factor) attachment protein (SNAP)- anatomy, 88, 89f, 864 Splenic marginal zone lymphoma (SMZL),
23, 926 architecture, 88, 89f, 90, 90f 1495t, 1557, 1558t, 1666–1667
Somatic cell nuclear transfer (SCNT), 448 B-cell development in, 1151 Splenomegaly. See also Hypersplenism
Somatic hypermutation, 1169 disorders in chronic lymphocytic leukemia, 1530
Somatic mutation, aging and, 130 in hereditary spherocytosis, 673 classification and causes, 863, 864, 865t,
Sorafenib, for acute myelogenous leukemia, hypersplenism. See Hypersplenism 866t
1403 hyposplenism, 867–869, 868t, 869f in clonal myeloid diseases, 1287
SOS (sinusoidal obstructive syndrome), 368 in Langerhans cell histiocytosis, consultative approach to, 48
Sotatercept 1104 in hairy cell leukemia, 1554
for myelodysplastic syndromes, 1360 in mastocytosis, 974 in juvenile myelomonocytic leukemia,
for myeloma, 1713 primary lymphomas, 1582 1471
Southeast Asian ovalocytosis (SAO), 670f, in sickle cell disease, 772 in Langerhans cell histiocytosis, 1104
680 in T-cell large granular lymphocytic neutropenia and, 996, 997
SOX11 (SOX11), 236t, 1653, 1655 leukemia, 1566, 1566f platelet transfusion in, 2385
SP140, 234t erythropoiesis in, 480 in primary myelofibrosis, 1324
20S particle, 240 examination, 8–9 in splenic marginal zone lymphoma, 1666
Specific granule deficiency, 1019t, 1020–1021 function, 90–91, 864 in thalassemia, 742
Spectrin macrophages in, 1081f, 1082 thrombocytopenia and, 2013
defects of ontogeny, 863 Splenoptosis, 865–866
in erythrocyte membrane disorders, Splenectomy Splice-site mutations, 146
670t for aplastic anemia, 527 Spontaneous abortions, 1988
in hereditary elliptocytosis, 677–678 atherosclerosis and, 2288 Spontaneous mutations, 146

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