Page 2527 - Williams Hematology ( PDFDrive )

2498 Index Index 2499

Thymus (Cont.): characteristics, 1930 Toll/interleukin-1 receptor (TIR), 295–297,
defective development in disseminated intravascular coagulation, 297f
CHARGE syndrome, 1222 2200, 2207 Toll/interleukin-1 receptor domain-
congenital alopecia and absence of in endothelial cells, 2285 containing adaptor inducing IFN-β
thymus, 1223 factor VIIa and, 1930, 1940, 1940f (TRIF), 297f, 298
DiGeorge syndrome, 86–87, 1214t, 1222 gene structure and variations, 1931, 1931f Toll-interleukin receptor adaptor protein
development, 1150–1151 in leukocytes, 2237 (TIRAP), 1054, 1230, 1352
immune function, 86–87, 87f sickle cell disease and, 765 Toll-like receptors (TLRs), 75
in Langerhans cell histiocytosis, 1104 structure, 1920f, 1930 in dendritic cells, 307
T-cell development in, 85–86, 87f Tissue factor pathway inhibitor (TFPI), discovery, 294–295
Thyroid disease/dysfunction 1959–1960 macrophage activation and, 1084
anemia and, 559 characteristics, 1916t, 1937 microbe recognition by, 294, 294t
Hodgkin lymphoma treatment and, 1618 in disseminated intravascular coagulation, in monocytes and macrophages, 1054,
primary lymphomas, 1583 2201, 2202 1055f
TIA-1, 1567 functions, 1922, 1937, 1960, 1968 in neutrophils, 1008
TIBC (total iron-binding capacity), 634 gene structure and variations, 1937, 1960 in platelets, 1873
Ticagrelor recombinant, 2214 signaling defects, 1230
for acute coronary syndromes, 2076 structure, 1937, 1952t, 1959–1960, 1959f signaling pathways, 296–298, 297f, 1055f
antiplatelet effects, 404t, 405 synthesis, 1960 structure, 295–296, 295f, 296f
TICAM1. See Toll/interleukin-1 receptor Tissue inhibitor of metalloproteinase Tomosyn1/syntaxin binding protein 5, 1849
domain-containing adaptor (TIMP-1), 1975 Tongue
inducing IFN-β (TRIF) Tissue iron compartment, 618 burning, in iron deficiency, 632
TICAM2. See TRIF-related adaptor molecule Tissue macrophages, 291 enlarged, in AL amyloidosis, 1774, 1775f
(TRAM) Tissue plasminogen activator (t-PA), 1973, 1975 examination of, 8
Ticlopidine Tissue thromboplastin inhibition test, 2243 hematoma, in hemophilia, 2118, 2119f
adverse effects, 2262 Tissue-type plasminogen activator (t-PA) history of pain or tingling in, 5
antiplatelet effects, 404t, 405, 2075–2076 in fibrinolysis, 2202, 2304f, 2306, 2307 Tonsils, 94, 1081f
Tigecycline, 384–385 for fibrinolytic therapy. See Fibrinolytic Tooth extractions. See Dental bleeding/
TILs (tumor-infiltrating lymphocytes), 412 therapy, agents for extractions
TIMP-1 (tissue inhibitor of gene, 2305–2306, 2306f Topoisomerase inhibitors, 326–329
metalloproteinase), 1975 in plasminogen activation, 2310 anthracyclines. See Anthracyclines
Tingible body macrophages, 1596 production, 1973 camptothecins, 326–328
Tingling in tongue, history of, 5 structure, 2303, 2304–2305t, 2305 secondary acute myelogenous leukemia
Tinzaparin, for venous thromboembolism, T-LGLL. See T-cell large granular and, 183, 1407
2274t lymphocytic leukemia (T-LGLL) Topotecan, 326–327
Tipifarnib TLI (total lymphoid irradiation), 360 TORC1 (target of rapamycin complex 1),
for acute myelogenous leukemia, 1459 TLR2, 236t 192
for primary myelofibrosis, 1329 TLR4, 1711 Torulopsis glabrata infection, 369
TIR (toll/interleukin-1 receptor), 295–297, TLR5, 1643 Total blood neutrophil pool (TBNP), 942,
297f TLRs. See Toll-like receptors (TLRs) 942t
TIRAP. See MyD88 adapter-like (MAL) TLX1, 186 Total blood volume, anemia and, 505, 505f
TIRAP (toll-interleukin receptor adaptor T lymphocytes. See T cells Total-body hematocrit, 489
protein), 1054, 1230, 1352 TM. See Thrombomodulin (TM) Total-body irradiation (TBI), 353, 359–360,
Tirofiban, 405 TMD (transient myeloproliferative disorder), 1656–1657
antiplatelet effects, 405, 2045, 2077 1385–1386 Total erythropoiesis, 490
clinical uses, 404t, 405 Tmprss6 (matriptase 2), 621, 621t Total iron-binding capacity (TIBC), 634
dosage, 404t TNF. See Tumor necrosis factor (TNF) Total lymphoid irradiation (TLI), 360
thrombocytopenia and, 2015, 2077 TNFAIP3 (A20), 235t, 236t, 1644, 1664t, Touch imprint, 29
for unstable angina, 2296 1786, 1787 Touch preparations, 30
Tissue TNFRSF14, 1627t Toxic granulation, 22f, 23
hypoxia, anemia and, 506 TNT (trinitrotoluene), 518 Toxic methemoglobinemia, 789, 790t, 792,
perfusion of, anemia and, 504–505, 505f Tobacco. See Cigarette smoking 793. See also Methemoglobinemia
Tissue factor (TF) Tobramycin, 387t Toxic oil syndrome, 959
activation and cofactor function, Tocilizumab Toxocara canis, 291, 957t
1930–1931 for Castleman disease, 1250 Toxoplasmosis
arterial thrombosis and, 2293–2294 for Erdheim-Chester disease, 1111 central nervous system, 1246

Kaushansky_index_p2393-2506.indd 2498 9/21/15 3:23 PM