Page 2529 - Williams Hematology ( PDFDrive )

2500 Index Index 2501

TRIM25 (T-cell receptor-interacting Tumor-associated macrophages (TAMs), Turmeric, 2079
molecule 25), 302, 302f 1083 TXA (thromboxane A ), 288, 1830, 1852f,
2
2
Trimethoprim, megaloblastic anemia and, Tumor-infiltrating lymphocytes (TILs), 412 1876–1877, 1968t
605, 606t Tumor lysis syndrome, 1287, 1502, 1535, TXB (thromboxane B ), 952
2
2
Trimethoprim-sulfamethoxazole 1539, 1675 TYK2, 232t
adverse effects, 1252 Tumor necrosis factor (TNF), monocytes Tyrosine kinase
as empiric therapy for infections, 386, 387t and, 1091 activation in neutrophils, 1016
prophylactic, 389, 1213, 1514 Tumor necrosis factor (TNF)-α phosphorylation, 1884
Trinitrotoluene (TNT), 518 in aplastic anemia, 515 in platelets, 1833t
Triosephosphate isomerase (TPI) basophils and, 969 Tyrosine kinase inhibitors, 338–341. See also
activity, 692t in cell membrane, 62t specific drugs
deficiency, 695, 700t, 704 in disseminated intravascular coagulation, for acute lymphoblastic leukemia, 1518
in glucose metabolism, 695 2200, 2208 for acute myelogenous leukemia, 1403
Trisomy 7, acute myelogenous leukemia and, effects on erythropoiesis, 550 adverse effects, 341
1383 in fibrinolysis, 2202 for chronic eosinophilic leukemia, 1470
Trisomy 8, 220t, 221t, 521, 1347, 1384t, in fibroplasia, 1322 for chronic myelogenous leukemia. See
1466 hematopoiesis and, 258f Chronic myelogenous (myeloid)
Trisomy 11, 181 in inflammation, 284, 287–288, 287t leukemia (CML), therapy
Trisomy 12, chronic lymphocytic leukemia in inflammatory response, 1978 comparison, 1451t
and, 187, 1529, 1531t, 1532t in innate immune response, 303 after hematopoietic cell transplantation,
Trisomy 19, 1466 interleukin-6 production and, 2036 1461–1462
Trisomy 21 in leukocyte adhesion, 281, 282 for mastocytosis, 977, 1279
acute lymphoblastic leukemia and, 1506 in myelodysplastic syndromes, 1352 mechanism of action, 338
acute myelogenous leukemia and, 1383, neutrophils and, 932, 933t, 1008 pharmacology, 338, 340–341
1386 in primary myelofibrosis, 1325 resistance to
neonatal leukemia and, 1386 in sepsis and septic shock, 285 chromosomal abnormalities associated
platelet abnormalities in, 2061 in sickle cell disease, 765 with, 230
tRNA (transfer RNA), 147 Tumor necrosis factor (TNF)-α receptors, in chronic myelogenous leukemia,
Tropical spastic paraparesis, 1573 249 1456–1458, 1457t
Tropical sprue, 597, 599 Tumor necrosis factor (TNF) receptor-1 gene mutations associated with, 178,
Tropomodulins, 663t, 1837 (TNFR1), 207–208, 207f 318, 340–341
Tropomyosin, 663t, 1832t Tumor necrosis factor (TNF) receptor- management, 1457–1458
True juvenile pernicious anemia, 607 associated factors (TRAFs). in mastocytosis, 1279
Tryptase, serum, 1470 See under TRAF mechanisms, 318, 319t, 338, 340,
Tryptophan, for sideroblastic anemia, 920 Tumor necrosis factor (TNF) receptor- 1456–1457
4T score, 2029, 2029t associated periodic syndrome response to, 1451–1452, 1452t, 1454–1455
t-SNARE, 1849 (TRAPS), 1025 secondary chromosomal changes with,
Tspan9, 1871 Tumor necrosis factor (TNF) receptor death 1456
TSPAN24. See CD151 domain (TRADD), 249, 302, 302f structure, 340f
TSPAN29. See CD9 Tumor necrosis factor (TNF) receptor Tyrosine kinase receptors, 1871–1872
TSPAN32. See TSSC6 superfamily, 204f, 249, 252
TSSC6, 1871 Tumor necrosis factor (TNF) receptor U
TTC7A, 1222 superfamily member 14 (LIGHT), U2AF1, 1349
TTP. See Thrombotic thrombocytopenic 1873 U2AF2, 1348
purpura (TTP) Tumor necrosis factor (TNF)-related Ubiquitin, 253
TTR (transthyretin), 1773, 1776, 1777–1778 apoptosis-inducing ligand UCM (upregulation of costimulatory
Tuberculosis (TRAIL), 204f, 205, 249, 951, 996, molecules), 304
lymphocytopenia and, 1204 1193, 1873 UGT1A1, 565, 567
macrophage-derived giant cells in, 1078, Tumor necrosis factor (TNF)-RII, in primary UIBC (unsaturated or latent iron-binding
1078f myelofibrosis, 1325 capacity), 634
monocytosis in, 1097 Tumors, solid Ulceration/ulcers
prophylaxis, in HIV infection, 1241t disseminated intravascular coagulation gastric, 629
Tubulin, 1838 and, 803–804, 2207–2208 leg, 6, 8, 771–772
β -Tubulin abnormalities, 2059 hematopoietic cell transplantation for, 362 mouth, 8
1
Tufted angioma, 2014 Tumor-suppressor genes, 219, 237–239 tongue, 5
Tumor antigens, 412t Tumor suppressors, 195 Ultrasonography

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