Page 2528 - Williams Hematology ( PDFDrive )

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2498 Index Index 2499

idiopathic CD4+ T lymphocytopenia and, Transcobalamin, 591, 591t, 592, 593, 593t, massive, thrombocytopenia associated
1206 1448 with, 2014
mononucleosis and, 1261, 1262t, 1268 Transcobalamin I and III. See Haptocorrins for sickle cell disease, 776
in pregnancy, 1269 Transcobalamin deficiency, 607 Transgenic animal models, 153
prophylaxis, in HIV infection, 1241t Transcription, 147 Transient aplastic crisis, 541–542
TP53 in hematopoietic stem cells, 262–263 Transient erythroblastopenia of childhood,
in acute myelogenous leukemia, 227t in lymphopoiesis, 1154–1155 541–542
in B-cell acute lymphoblastic leukemia, Transcription activator-like effector nuclease Transient ischemic attacks, 2238–2239
232t (TALEN), 444 Transient myeloproliferative disorder (TMD),
in chronic lymphocytic leukemia, 231t, Transcription factors, 165–166, 267–268 1385–1386
1529 Transcriptome, 161, 1851, 1853–1854 Transitional cells, marrow, 32t
in chronic myelogenous leukemia, 230t Transcriptomics, platelet, 1851–1853, 1852f Transketolase, 692t, 697
in mantle cell lymphoma, 236t Transdifferentiation, 269 Translation, 147
in myelodysplastic syndromes, 228t, 1346t, Transferrin, 618 Translocations, 173, 174, 175t, 251
1347, 1348, 1352 in anemia of chronic inflammation, 552 Transmembrane activator and calcium
in myeloma, 233t, 1735f, 1736, 1736t, 1737, endocytosis of, 622–623, 623f modulator and cyclophilin ligand
1759 iron-binding capacity and, 634 interactor (TACI), 1606
in plasma cell leukemia, 1736t in iron homeostasis, 621t, 917f, 918 Transplantation
in Waldenström macroglobulinemia, 1788 levels of, in newborn, 104 alloimmune hemolytic anemia following,
t-PA. See Tissue plasminogen activator (t-PA) Transferrin receptor-1, 621, 621t, 623 836
TPI. See Triosephosphate isomerase (TPI) Transferrin receptor-2, 621, 621t, 623 cytomegalovirus infection following,
T-PLL (T-cell prolymphocytic lymphoma), Transferrin receptors, 622–623, 623f, 635, 1267–1268
1498t, 1542 1058t hematopoietic cell. See Hematopoietic cell
TPO. See Thrombopoietin (TPO) Transfer RNA (tRNA), 147 transplantation (HCT)
Trace metal deficiency, 653–654 Transforming growth factor (TGF) α, 62t liver. See Liver transplantation
TRADD (TNF receptor death domain), 207f, Transforming growth factor (TGF) β, 266 red cell transfusion and, 2374
249, 302, 302f atherosclerosis and, 2288 renal. See Renal transplantation
TRAF, 249, 298, 302, 302f in chronic myelogenous leukemia, 1440 thrombotic microangiopathy following,
TRAF2 (TRAF2), 207, 207f, 236t in fibroplasia, 1322 2262
TRAF3 (TRAF3), 233t, 1711, 1737 in macrophages, 1070t Transport compartment, plasma, 618
TRAF6 (TRAF6), 298, 1220, 1352 in megakaryopoiesis, 1823 Transthyretin (TTR), 1773, 1776, 1777–1778
TRAIL (TNF-related apoptosis-inducing in platelets, 1848 TRAPS (TNF receptor-associated periodic
ligand), 204f, 205, 249, 951, 996, Transforming growth factor (TGF) β family, syndrome), 1025
1193, 1873 249 Trauma
Trained immunity, 168 Transfusion reactions disseminated intravascular coagulation
TRALI (transfusion-related acute lung acute hemolytic, 2374–2375 and, 2204t, 2208
injury), 2359, 2375–2376 acute lung injury, 2359, 2375–2376 vascular purpura and, 2107
TRAM (TRIF-related adaptor molecule), allergic, 2375 T REG (regulatory T) cells. See CD4+CD25+
297f, 298, 1008, 1054 circulatory overload, 2376 regulatory T (T REG ) cells
Tranexamic acid delayed hemolytic, 2372, 2377 TREM (triggering receptors expressed on
adverse effects, 2318 disseminated intravascular coagulation myeloid cells)-like transcript-1
for bleeding not response to platelet and, 2210 (TLT-1), 1869
transfusion, 2385 febrile nonhemolytic, 2375 Trench fever, 818
in cardiopulmonary bypass, 2086 graft-versus-host disease, 2374, 2377 Treponema pallidum infections, 290
for combined deficiency of factors V and HNA antibodies and, 2358–2359 TRF-1101, for sickle cell disease, 777t
VIII, 2140 pathophysiology, 2348 Triamterene, megaloblastic anemia and, 606t
for disseminated intravascular coagulation, sepsis, 2376 Tricarboxylic acid (TCA) cycle, 192, 193f
2214 Transfusions. See also Exchange transfusion; Trichinella spiralis, 949, 956, 957t
for epistaxis, 2139 Platelet transfusion; Red cell TRIF (toll/interleukin-1 receptor domain-
for hemophilia A, 2123 transfusion containing adaptor inducing
for inherited platelet disorders, 2062 for acquired pure red cell aplasia, 544 IFN-β), 297f, 298
for mucosal bleeding in immune for autoimmune hemolytic anemia, 837 TRIF-related adaptor molecule (TRAM),
thrombocytopenia, 2007 for cobalamin deficiency, 584 297f, 298, 1008, 1054
pharmacology, 2317–2318 for G6PD deficiency, 711–712 Triggering receptors expressed on myeloid
for von Willebrand disease, 2176 intrauterine fetal, 854–855 cells (TREM)-like transcript-1
Transaldolase, 692t, 697, 701t iron overload and, 641 (TLT-1), 1869

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