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2496 Index Index 2497

in Kasabach-Merritt syndrome (KMS), Thromboplastin. See Tissue factor (TF) classification, 2255t
806, 2014–2015 Thrombopoiesis, 1815–1821 in cobalamin metabolic defects, 2263
in large granular lymphocytic leukemia, 1566 cellular physiology, 1815–1821 in disseminated intravascular coagulation,
in leukemias, 2081–2082 megakaryopoiesis. See 2261
massive transfusion and, 2014 Megakaryopoiesis drug-induced, 428, 431, 2262–2263
in myelodysplastic syndromes, 1353, platelet formation, 1820–1821 hemolytic uremic syndrome. See
2081–2082 kinetics, 1815 Hemolytic uremic syndrome
in myeloma, 1740 in newborns, 107–108 (HUS)
neonatal alloimmune, 2012–2013 regulation, 2035 in HIV infection, 1252
nutritional deficiencies and, 1997–1998 therapeutic manipulation, 1824–1825 in infections, 2261–2262
in paroxysmal nocturnal hemoglobinuria, Thrombopoietin (TPO) in malignant hypertension, 2263
580 actions, 265 mechanical hemolysis and, 2263
from platelet trapping, 2014–2015 in DNA repair, 268 in organ transplant recipients, 2262
during pregnancy, 121–122, 580, 802, in hematopoietic stem cells, 261, 264t, 265 plasma exchange for, 428, 430t, 431
2010–2012, 2010t in immune thrombocytopenia, 2000–2001 in pregnancy, 2262
purpuras in, 2107 in megakaryopoiesis, 64–65, 1817, thrombotic thrombocytopenic purpura.
splenomegaly and, 2013 1822–1823 See Thrombotic thrombocytopenic
spurious (pseudothrombocytopenia), 43, in newborn, 107 purpura (TTP)
1994–1996 regulation, 2000 Thrombotic thrombocytopenic purpura
in thrombotic thrombocytopenic purpura, for thrombocytopenia, 1824–1825 (TTP)
2255 Thrombopoietin (TPO) receptor (c-mpl, clinical features, 2107, 2254–2255
treatment, 1824–1825, 2213, 2385 CD110), 260, 265, 1822, 1872, 2036 congenital, 2257–2258
in von Willebrand disease, 2172 Thrombopoietin (TPO) receptor agonists. See course and prognosis, 2257
X-linked, 1224–1225 also Eltrombopag; Romiplostim definition and history, 2253–2254
Thrombocytopenia and absent radii (TAR) adverse effects, 2006 differential diagnosis, 837, 2255–2256,
syndrome, 1996, 1997f, 2061 for aplastic anemia, 526 2255t
Thrombocytosis development, 1825, 2001 epidemiology, 2254
consultative approach to, 45 for hypersplenism, 867 etiology and pathogenesis, 428, 2254
etiology, 1312t, 2036t for immune thrombocytopenia, laboratory features, 2255
reactive, 1310, 1312t, 2035–2037 2005–2006 treatment, 428, 2256–2257
thrombocytapheresis for, 433 for myelodysplastic syndromes, 1358 Thromboxane A (TXA ), 288, 1830, 1852f,
2
2
Thromboembolectomy, 2316–2317 Thromboregulation, 1968 1876–1877, 1968t, 2074
Thromboembolism. See Venous thrombosis/ Thromboregulatory molecules, endothelial, Thromboxane A (TXA ) receptor defect,
2
2
thromboembolism 1967–1968, 1968f, 1968t 2056
β-Thromboglobulins, 1844–1845 Thrombosis. See also Arterial thrombosis; Thromboxane B (TXB ), 952
2
2
Thrombokinase, 2113 Venous thrombosis Thromboxane prostanoid receptor,
Thrombolytic therapy. See Fibrinolytic acute myelogenous leukemia treatment 1876–1877
therapy and, 1410 Thromboxane synthase deficiency, 2058
Thrombomodulin (TM), 1953 in disseminated intravascular coagulation, Thrombus. See also Thrombosis
blood fluidity and, 2285 2204 formation, 1829–1834
characteristics, 1916t, 1931 in essential thrombocythemia, 1308, red, 2292
functions, 1931, 1952t, 1972 1309f white, 2291
gene structure and variations, 1931–1932, fibrinolytic deficiency and, 2311–2312 Thymectomy, for autoimmune hemolytic
1932f, 1953 in hemophilia, 2130 anemia, 839
protein C activation and, 1954, 1972, 2202 inflammatory mediators in, 1978–1979, Thymic corpuscles, 85
structure, 1931, 1951f, 1952t 1979t Thymic progenitors, 1154
Thrombophilia in newborns, 112 Thymidine kinase, 1532, 1532t
acquired, 2221, 2224t. See also in polycythemia vera, 1293 Thymidylate synthesis, 586t, 587f
Antiphospholipid syndrome (APS) in primary myelofibrosis, 1325 Thymocytes, 85–86, 87f, 1141, 1142f,
in clonal myeloid diseases, 1286 Thrombospondin, 63, 765, 1856, 1879 1179
definition, 2221 Thrombospondin-1, 1845, 1846t, 1848 Thymoma, 518, 544, 1204
hereditary. See Hereditary thrombophilia Thrombospondin N-terminal fragment Thymosin β , 1832t, 1839f, 1841, 1848
4
in paroxysmal nocturnal hemoglobinuria, (GMP-33), 1873 Thymus, 85–87
580 Thrombotic microangiopathies, 2253–2263 aging of, 131, 133, 133f
during pregnancy and puerperium, in autoimmune disorders, 2262 anatomy, 85
122–123 in cancer, 2262 architecture, 85–86, 86f

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