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80. Dostert C, Petrilli V, Van Bruggen R, et al: Innate immune activation through Nalp3 113. Cella M, Jarrossay D, Facchetti F, et al: Plasmacytoid monocytes migrate to inflamed
inflammasome sensing of asbestos and silica. Science 320:674, 2008. lymph nodes and produce large amounts of type I interferon. Nat Med 5:919, 1999.
81. Pelegrin P, Barroso-Gutierrez C, Surprenant A: P2X7 receptor differentially couples to 114. Lewis PA, Loomis D: The formation of anti-sheep hemolytic amboceptor in the normal
distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180:7147, 2008. and tuberculous guinea pig. J Exp Med 40:503, 1924.
82. Girardin SE, Boneca IG, Carneiro LA, et al: Nod1 detects a unique muropeptide from 115. Freund J, McDermott K: Sensitization to horse serum by means of adjuvants. Proc Soc
Gram-negative bacterial peptidoglycan. Science 300:1584, 2003. Exp Biol Med 49:548, 1942.
83. Girardin SE, Boneca IG, Viala J, et al: Nod2 is a general sensor of peptidoglycan through 116. Condie RM, Zak SJ, Good RA: Effect of meningococcal endotoxin on the immune
muramyl dipeptide (MDP) detection. J Biol Chem 278:8869, 2003. response. Proc Soc Exp Biol Med 90:355, 1955.
84. Girardin SE, Travassos LH, Herve M, et al: Peptidoglycan molecular requirements 117. Skidmore BJ, Chiller JM, Morrison DC, Weigle WO: Immunologic properties of bacte-
allowing detection by Nod1 and Nod2. J Biol Chem 278:41702, 2003. rial lipopolysaccharide (LPS): Correlation between the mitogenic, adjuvant, and immu-
85. Hsu LC, Ali SR, McGillivray S, et al: A NOD2-NALP1 complex mediates caspase-1- nogenic activities. J Immunol 114:770, 1975.
dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl 118. Germain RN, Jenkins MK: In vivo antigen presentation. Curr Opin Immunol 16:120,
dipeptide. Proc Natl Acad Sci U S A 105:7803, 2008. 2004.
86. Loo YM, Gale M Jr: Immune signaling by RIG-I-like receptors. Immunity 34:680, 2011. 119. Borriello F, Sethna MP, Boyd SD, et al: B7-1 and B7-2 have overlapping, critical roles in
87. Saito T, Hirai R, Loo YM, et al: Regulation of innate antiviral defenses through a shared immunoglobulin class switching and germinal center formation. Immunity 6:303, 1997.
repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A 104:582, 2007. 120. Yamamoto M, Sato S, Hemmi H, et al: Role of adaptor TRIF in the MyD88-independent
88. Takahasi K, Yoneyama M, Nishihori T, et al: Nonself RNA-sensing mechanism of RIG-I Toll-like receptor signaling pathway. Science 301:640, 2003.
helicase and activation of antiviral immune responses. Mol Cell 29:428, 2008. 121. Gavin AL, Hoebe K, Duong B, et al: Adjuvant-enhanced antibody responses in the
89. Pippig DA, Hellmuth JC, Cui S, et al: The regulatory domain of the RIG-I family absence of Toll-like receptor signaling. Science 314:1936, 2006.
ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res 37:2014, 2009. 122. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW: Genetic and environmental
90. Rothenfusser S, Goutagny N, Diperna G, et al: The RNA helicase Lgp2 inhibits influences on premature death in adult adoptees. N Engl J Med 318:727, 1988.
TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immu- 123. Smirnova I, Mann N, Dols A, et al: Assay of locus-specific genetic load implicates rare
nol 175:5260, 2005. Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A
91. Venkataraman T, Valdes M, Elsby R, et al: Loss of DExD/H box RNA helicase LGP2 100:6075, 2003.
manifests disparate antiviral responses. J Immunol 178:6444, 2007. 124. Hawn TR, Verbon A, Lettinga KD, et al: A common dominant TLR5 stop codon poly-
92. Satoh T, Kato H, Kumagai Y, et al: LGP2 is a positive regulator of RIG-I- and MDA5- morphism abolishes flagellin signaling and is associated with susceptibility to Legion-
mediated antiviral responses. Proc Natl Acad Sci U S A 107:1512, 2010. naires’ disease. J Exp Med 198:1563, 2003.
93. Gitlin L, Barchet W, Gilfillan S, et al: Essential role of mda-5 in type I IFN responses to 125. Picard C, Puel A, Bonnet M, et al: Pyogenic bacterial infections in humans with IRAK-4
polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc deficiency. Science 299:2076, 2003.
Natl Acad Sci U S A 103:8459, 2006. 126. Zhang SY, Jouanguy E, Ugolini S, et al: TLR3 deficiency in patients with herpes simplex
94. Hornung V, Ellegast J, Kim S, et al: 5′-Triphosphate RNA is the ligand for RIG-I. Science encephalitis. Science 317:1522, 2007.
314:994, 2006. 127. Casrouge A, Zhang SY, Eidenschenk C, et al: Herpes simplex virus encephalitis in
95. Pichlmair A, Schulz O, Tan CP, et al: RIG-I-mediated antiviral responses to sin- human UNC-93B deficiency. Science 314:308, 2006.
gle-stranded RNA bearing 5′-phosphates. Science 314:997, 2006. 128. Jouanguy E, Altare F, Lamhamedi S, et al: Interferon-gamma-receptor deficiency in an
96. Kawai T, Takahashi K, Sato S, et al: IPS-1, an adaptor triggering RIG-I- and Mda5- infant with fatal bacille Calmette-Guerin infection. N Engl J Med 335:1956, 1996.
mediated type I interferon induction. Nat Immunol 6:981, 2005. 129. Picard C, Fieschi C, Altare F, et al: Inherited interleukin-12 deficiency: IL12B genotype
97. Seth RB, Sun L, Ea CK, Chen ZJ: Identification and characterization of MAVS, a mito- and clinical phenotype of 13 patients from six kindreds. Am J Hum Genet Hum Genet
chondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122:669, 70:336, 2002.
2005. 130. Altare F, Durandy A, Lammas D, et al: Impairment of mycobacterial immunity in
98. Xu LG, Wang YY, Han KJ, et al: VISA is an adapter protein required for virus-triggered human interleukin-12 receptor deficiency. Science 280:1432, 1998.
IFN-beta signaling. Mol Cell 19:727, 2005. 131. De Jong R, Altare F, Haagen IA, et al: Severe mycobacterial and Salmonella infections in
99. Meylan E, Curran J, Hofmann K, et al: Cardif is an adaptor protein in the RIG-I antiviral interleukin-12 receptor-deficient patients. Science 280:1435, 1998.
pathway and is targeted by hepatitis C virus. Nature 437:1167, 2005. 132. Barbosa MD, Nguyen QA, Tchernev VT, et al: Identification of the homologous beige
100. Hou F, Sun L, Zheng H, et al: MAVS forms functional prion-like aggregates to activate and Chediak-Higashi syndrome genes. Nature 382:262, 1996.
and propagate antiviral innate immune response. Cell 146:448, 2011. 133. Royer-Pokora B, Kunkel LM, Monaco AP, et al: Cloning the gene for an inherited
101. Sun L, Wu J, Du F, et al: Cyclic GMP-AMP synthase is a cytosolic DNA sensor that human disorder—chronic granulomatous disease—on the basis of its chromosomal
activates the type I interferon pathway. Science 339:786, 2013. location. Nature 322:32, 1986.
102. Wu J, Sun L, Chen X, et al: Cyclic GMP-AMP is an endogenous second messenger in 134. Leadbetter EA, Rifkin IR, Hohlbaum AM, et al: Chromatin-IgG complexes activate B
innate immune signaling by cytosolic DNA. Science 339:826, 2013. cells by dual engagement of IgM and Toll-like receptors. Nature 416:603, 2002.
103. Ishikawa H, Barber GN: STING is an endoplasmic reticulum adaptor that facilitates 135. Crozat K, Hoebe K, Ugolini S, et al: Jinx, an MCMV susceptibility phenotype caused by
innate immune signalling. Nature 455:674, 2008. disruption of Unc13d: A mouse model of type 3 familial hemophagocytic lymphohisti-
104. Takaoka A, Wang Z, Choi MK, et al: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and ocytosis. J Exp Med 204:853, 2007.
an activator of innate immune response. Nature 448:501, 2007. 136. Croker BA, Lawson BR, Berger M, et al: Inflammation and autoimmunity caused by a
105. Wang Z, Choi MK, Ban T, et al: Regulation of innate immune responses by DAI SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U
(DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci U S A 105:5477, S A 105:15028, 2008.
2008. 137. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al: Mal (MyD88-adapter-like) is
106. Zeng M, Hu Z, Shi X, et al: MAVS, cGAS, and endogenous retroviruses in T-independent required for Toll-like receptor-4 signal transduction. Nature 413:78, 2001.
B cell responses. Science 346:1486, 2014. 138. Horng T, Barton GM, Medzhitov R: TIRAP: An adapter molecule in the Toll signaling
107. Beutler B, Milsark IW, Cerami AC: Passive immunization against cachectin/tumor pathway. Nat Immunol 2:835, 2001.
necrosis factor protects mice from lethal effect of endotoxin. Science 229:869, 1985. 139. Yamamoto M, Sato S, Hemmi H, et al: Essential role for TIRAP in activation of the
108. Georgel P, Naitza S, Kappler C, et al: Drosophila immune deficiency (IMD) is a death signalling cascade shared by TLR2 and TLR4. Nature 420:324, 2002.
domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell 140. Poltorak A, Smirnova I, He XL, et al: Genetic and physical mapping of the Lps locus-
1:503, 2001. identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells
109. Orange JS, Biron CA: Characterization of early IL-12, IFN-alpha/beta, and TNF effects Mol Dis 24:340, 1998.
on antiviral state and NK cell responses during murine cytomegalovirus infection. 141. Takeuchi O, Kawai T, Muhlradt PF, et al: Discrimination of bacterial lipoproteins by
J Immunol 156:4746, 1996. Toll-like receptor 6. Int Immunol 13:933, 2001.
110. Andrews DM, Scalzo AA, Yokoyama WM, et al: Functional interactions between den- 142. Hemmi H, Kaisho T, Takeuchi O, et al: Small anti-viral compounds activate immune
dritic cells and NK cells during viral infection. Nat Immunol 4:175, 2003. cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196, 2002.
111. Mancuso G, Midiri A, Biondo C, et al: Type I IFN signaling is crucial for host resistance 143. Jurk M, Heil F, Vollmer J, et al: Human TLR7 or TLR8 independently confer responsive-
against different species of pathogenic bacteria. J Immunol 178:3126, 2007. ness to the antiviral compound R-848. Nat Immunol 3:499, 2002.
112. Karaghiosoff M, Steinborn R, Kovarik P, et al: Central role for type I interferons and 144. Chuang T, Ulevitch RJ: Identification of hTLR10: A novel human Toll-like receptor
Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 4:471, 2003. preferentially expressed in immune cells. Biochim Biophys Acta 1518:157, 2001.

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