Page 330 - Williams Hematology ( PDFDrive )

304 Part IV: Molecular and Cellular Hematology Chapter 20: Innate Immunity 305

13. Hayashi F, Smith KD, Ozinsky A, et al: The innate immune response to bacterial 47. Tseng PH, Matsuzawa A, Zhang W, et al: Different modes of ubiquitination of the adap-
flagellin is mediated by Toll- like receptor 5. Nature 410:1099, 2001. tor TRAF3 selectively activate the expression of type I interferons and proinflammatory
14. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of double-stranded cytokines. Nat Immunol 11:70, 2010.
RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732, 2001. 48. Chen ZJ: Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7:758, 2005.
15. Poltorak A, Ricciardi-Castagnoli P, Citterio A, Beutler B: Physical contact between 49. West AP, Brodsky IE, Rahner C, et al: TLR signalling augments macrophage bacteri-
LPS and Tlr4 revealed by genetic complementation. Proc Natl Acad Sci U S A 97:2163, cidal activity through mitochondrial ROS. Nature 472:476, 2011.
2000. 50. Waterfield M, Jin W, Reiley W, et al: IkappaB kinase is an essential component of the
16. Bauer S, Kirschning CJ, Hacker H, et al: Human TLR9 confers responsiveness to bacte- Tpl2 signaling pathway. Mol Cell Biol 24:6040, 2004.
rial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A 98:9237, 51. Beinke S, Deka J, Lang V, et al: NF-kappaB1 p105 negatively regulates TPL-2 MEK
2001. kinase activity. Mol Cell Biol 23:4739, 2003.
17. Gross O, Gewies A, Finger K, et al: Card9 controls a non-TLR signalling pathway for 52. Fitzgerald KA, McWhirter SM, Faia KL, et al: IKKepsilon and TBK1 are essential com-
innate anti-fungal immunity. Nature 442:651, 2006. ponents of the IRF3 signaling pathway. Nat Immunol 4:491, 2003.
18. Rogers NC, Slack EC, Edwards AD, et al: Syk-dependent cytokine induction by Dec- 53. Sato S, Sugiyama M, Yamamoto M, et al: Toll/IL-1 receptor domain-containing adap-
tin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22:507, tor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and
2005. TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B
19. Gantner BN, Simmons RM, Canavera SJ, et al: Collaborative induction of inflammatory and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 171:4304,
responses by dectin-1 and Toll-like receptor 2. J Exp Med 197:1107, 2003. 2003.
20. Rallabhandi P, Nhu QM, Toshchakov VY, et al: Analysis of proteinase-activated recep- 54. Kawasaki T, Takemura N, Standley DM, et al: The second messenger phosphatidyli-
tor 2 and TLR4 signal transduction: A novel paradigm for receptor cooperativity. J Biol nositol-5-phosphate facilitates antiviral innate immune signaling. Cell Host Microbe
Chem 283:24314, 2008. 14:148, 2013.
21. Wright SD, Ramos RA, Tobias PS, et al: CD14, a receptor for complexes of lipopolysac- 55. Ordureau A, Enesa K, Nanda S, et al: DEAF1 is a Pellino1-interacting protein required
charide (LPS) and LPS binding protein. Science 249:1431, 1990. for interferon production by Sendai virus and double-stranded RNA. J Biol Chem
22. Haziot A, Ferrero E, Kontgen F, et al: Resistance to endotoxin shock and reduced dis- 288:24569, 2013.
semination of gram-negative bacteria in CD14-deficient mice. Immunity 4:407, 1996. 56. Kawai T, Sato S, Ishii KJ, et al: Interferon-alpha induction through Toll-like receptors
23. Hoebe K, Georgel P, Rutschmann S, et al: CD36 is a sensor of diacylglycerides. Nature involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 5:1061,
433:523, 2005. 2004.
24. Nagai Y, Akashi S, Nagafuku M, et al: Essential role of MD-2 in LPS responsiveness and 57. Shinohara ML, Lu L, Bu J, et al: Osteopontin expression is essential for interferon-alpha
TLR4 distribution. Nat Immunol 3:667, 2002. production by plasmacytoid dendritic cells. Nat Immunol 7:498, 2006.
25. Xu Y, Tao X, Shen B, et al: Structural basis for signal transduction by the Toll/interleukin-1 58. Negishi H, Fujita Y, Yanai H, et al: Evidence for licensing of IFN-gamma-induced IFN
receptor domains. Nature 408:111, 2000. regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene
26. Kim HM, Park BS, Kim JI, et al: Crystal structure of the TLR4-MD-2 complex with induction program. Proc Natl Acad Sci U S A 103:15136, 2006.
bound endotoxin antagonist Eritoran. Cell 130:906, 2007. 59. Honda K, Ohba Y, Yanai H, et al: Spatiotemporal regulation of MyD88-IRF-7 signalling
27. Ohto U, Fukase K, Miyake K, Satow Y: Crystal structures of human MD-2 and its com- for robust type-I interferon induction. Nature 434:1035, 2005.
plex with antiendotoxic lipid IVa. Science 316:1632, 2007. 60. Hoebe K, Janssen EM, Kim SO, et al: Upregulation of costimulatory molecules induced
28. Jin MS, Kim SE, Heo JY, et al: Crystal structure of the TLR1-TLR2 heterodimer induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and
by binding of a tri-acylated lipopeptide. Cell 130:1071, 2007. Trif-independent pathways. Nat Immunol 4:1223, 2003.
29. Liu L, Botos I, Wang Y, et al: Structural basis of Toll-like receptor 3 signaling with 61. Kaisho T: Type I interferon production by nucleic acid-stimulated dendritic cells. Front
double-stranded RNA. Science 320:379, 2008. Biosci 13:6034, 2008.
30. Ahmad-Nejad P, Hacker H, Rutz M, et al: Bacterial CpG-DNA and lipopolysaccharides 62. Chang M, Jin W, Sun SC: Peli1 facilitates TRIF-dependent Toll-like receptor signaling
activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32:1958, and proinflammatory cytokine production. Nat Immunol 10:1089, 2009.
2002. 63. Kobayashi K, Hernandez LD, Galan JE, et al: IRAK-M is a negative regulator of Toll-like
31. Tabeta K, Hoebe K, Janssen EM, et al: The Unc93b1 mutation 3d disrupts exogenous receptor signaling. Cell 110:191, 2002.
antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7:156, 64. Kinjyo I, Hanada T, Inagaki-Ohara K, et al: SOCS1/JAB is a negative regulator of
2006. LPS-induced macrophage activation. Immunity 17:583, 2002.
32. Kim YM, Brinkmann MM, Paquet ME, Ploegh HL: UNC93B1 delivers nucleotide- 65. Ye Z, Ting JP: NLR, the nucleotide-binding domain leucine-rich repeat containing gene
sensing Toll-like receptors to endolysosomes. Nature 452:234, 2008. family. Curr Opin Immunol 20:3, 2008.
33. Takahashi K, Shibata T, Akashi-Takamura S, et al: A protein associated with Toll-like 66. Hugot JP, Chamaillard M, Zouali H, et al: Association of NOD2 leucine-rich repeat
receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J Exp variants with susceptibility to Crohn’s disease. Nature 411:599, 2001.
Med 204:2963, 2007. 67. Miceli-Richard C, Lesage S, Rybojad M, et al: CARD15 mutations in Blau syndrome.
34. Yang Y, Liu B, Dai J, et al: Heat shock protein gp96 is a master chaperone for Toll-like Nat Genet 29:19, 2001.
receptors and is important in the innate function of macrophages. Immunity 26:215, 68. Hoffman HM, Mueller JL, Broide DH, et al: Mutation of a new gene encoding a putative
2007. pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells
35. Ewald SE, Lee BL, Lau L, et al: The ectodomain of Toll-like receptor 9 is cleaved to syndrome. Nat Genet 29:301, 2001.
generate a functional receptor. Nature 456:658, 2008. 69. Feldmann J, Prieur AM, Quartier P, et al: Chronic infantile neurological cutaneous and
36. Park B, Brinkmann MM, Spooner E, et al: Proteolytic cleavage in an endolysosomal articular syndrome is caused by mutations in CIAS1, a gene highly expressed in poly-
compartment is required for activation of Toll-like receptor 9. Nat Immunol 9:1407, morphonuclear cells and chondrocytes. Am J Hum Genet Hum Genet 71:198, 2002.
2008. 70. Neven B, Callebaut I, Prieur AM, et al: Molecular basis of the spectral expression of
37. Blasius AL, Arnold CN, Georgel P, et al: Slc15a4, AP-3, and Hermansky-Pudlak syn- CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disor-
drome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic ders CINCA/NOMID, MWS, and FCU. Blood 103:2809, 2004.
cells. Proc Natl Acad Sci U S A 107:19973, 2010. 71. The International FMF Consortium: Ancient missense mutations in a new member
38. Sasai M, Linehan MM, Iwasaki A: Bifurcation of Toll-like receptor 9 signaling by adap- of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797,
tor protein 3. Science 329:1530, 2010. 1997.
39. Beutler B, Jiang Z, Georgel P, et al: Genetic analysis of host resistance: Toll-Like receptor 72. Wise CA, Gillum JD, Seidman CE, et al: Mutations in CD2BP1 disrupt binding to PTP
signaling and immunity at large. Annu Rev Immunol 24:353, 2006. PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum
40. Kawai T, Akira S: TLR signaling. Semin Immunol 19:24, 2007. Mol Genet 11:961, 2002.
41. Yamamoto M, Sato S, Hemmi H, et al: TRAM is specifically involved in the Toll-like 73. Miao EA, Andersen-Nissen E, Warren SE, Aderem A: TLR5 and Ipaf: Dual sensors of
receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4:1144, bacterial flagellin in the innate immune system. Semin Immunopathol 29:275, 2007.
2003. 74. Boyden ED, Dietrich WF: Nalp1b controls mouse macrophage susceptibility to anthrax
42. Hoebe K, Du X, Georgel P, et al: Identification of Lps2 as a key transducer of lethal toxin. Nat Genet 38:240, 2006.
MyD88-independent TIR signaling. Nature 424:743, 2003. 75. Bruey JM, Bruey-Sedano N, Luciano F, et al: Bcl-2 and Bcl-XL regulate proinflamma-
43. Takeuchi O, Hoshino K, Akira S: Cutting edge: TLR2-deficient and MyD88-deficient tory caspase-1 activation by interaction with NALP1. Cell 129:45, 2007.
mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165:5392, 76. Martinon F, Agostini L, Meylan E, Tschopp J: Identification of bacterial muramyl
2000. dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929, 2004.
44. von Bernuth H, Picard C, Jin Z, et al: Pyogenic bacterial infections in humans with 77. Mariathasan S, Newton K, Monack DM, et al: Differential activation of the inflam-
MyD88 deficiency. Science 321:691, 2008. masome by caspase-1 adaptors ASC and Ipaf. Nature 430:213, 2004.
45. Lin SC, Lo YC, Wu H: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/ 78. Cassel SL, Eisenbarth SC, Iyer SS, et al: The Nalp3 inflammasome is essential for the
IL-1R signalling. Nature 465:885, 2010. development of silicosis. Proc Natl Acad Sci U S A 105:9035, 2008.
46. Oshiumi H, Matsumoto M, Funami K, et al: TICAM-1, an adaptor molecule that 79. Eisenbarth SC, Colegio OR, O’Connor W, et al: Crucial role for the Nalp3 inflam-
participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol masome in the immunostimulatory properties of aluminium adjuvants. Nature
4:161, 2003. 453:1122, 2008.

Kaushansky_chapter 20_p0293-0306.indd 305 9/17/15 5:52 PM