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492  Part VI:  The Erythrocyte                                                   Chapter 32:  Erythropoiesis          493




                    93.  Ebert BL, Bunn HF: Regulation of the erythropoietin gene. Blood 94(6):1864, 1999.    126. Baek JH, Liu YV, McDonald KR, et al: Spermidine/spermine N(1)-acetyltransferase-1
                    94.  Constantinescu SN, Keren T, Socolovsky M, et al: Ligand-independent oligomerization   binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and rack1 and promotes ubiq-
                     of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc   uitination and degradation of HIF-1alpha. J Biol Chem 282(46):33358, 2007.
                     Natl Acad Sci U S A 98(8):4379, 2001.                127. Gruber M, Hu CJ, Johnson RS, et al: Acute postnatal ablation of HIF-2alpha results in
                    95.  Witthuhn BA, Quelle FW, Silvennoinen O, et al: Jak2 associates with the erythropoietin   anemia. Proc Natl Acad Sci U S A 104(7):2301, 2007.
                     receptor and is tyrosine phosphorylated and activated following stimulation with ery-    128. Chavez JC, Baranova O, Lin J, et al: The transcriptional activator hypoxia inducible
                     thropoietin. Cell 74(2):227, 1993.                    factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin
                    96.  Damen JE, Wakao H, Miyajima A, et al: Tyrosine 343 in the erythropoietin receptor   in cortical astrocytes. J Neurosci 26(37):9471, 2006.
                     positively  regulates  erythropoietin-induced  cell  proliferation  and  stat5  activation.     129. Sanchez M, Galy B, Muckenthaler MU, et al: Iron-regulatory proteins limit hypoxia-
                     EMBO J 14(22):5557, 1995.                             inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 14(5):420,
                    97.  Parganas E, Wang D, Stravopodis D, et al: Jak2 is essential for signaling through a vari-  2007.
                     ety of cytokine receptors. Cell 93(3):385, 1998.     130. Percy MJ, Furlow PW, Lucas GS, et al: A gain-of-function mutation in the HIF2a gene
                    98.  Divoky V, Prchal JT: Mouse surviving solely on human erythropoietin receptor (EPOR):   in familial erythrocytosis. N Engl J Med 358(2):162, 2008.
                     Model of human EPOR-linked disease. Blood 99(10):3873; author reply 3874, 2002.    131.  Liu YV, Baek JH, Zhang H, et al: Rack1 competes with hsp90 for binding to HIF-1alpha
                    99.  Lin CS, Lim SK, D’Agati V, et al: Differential effects of an erythropoietin receptor gene   and is required for O(2)-independent and hsp90 inhibitor-induced degradation of
                     disruption on primitive and definitive erythropoiesis. Genes Dev 10(2):154, 1996.  HIF-1alpha. Mol Cell 25(2):207, 2007.
                    100. D’Andrea AD, Yoshimura A, Youssoufian H, et al: The cytoplasmic region of the ery-    132. Epstein AC, Gleadle JM, McNeill LA, et al: C. Elegans egl-9 and mammalian homo-
                     thropoietin receptor contains nonoverlapping positive and negative growth-regulatory   logs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell
                     domains. Mol Cell Biol 11(4):1980, 1991.              107(1):43, 2001.
                    101. Klingmuller U, Lorenz U, Cantley LC, et al: Specific recruitment of sh-ptp1 to the ery-    133. Correa PN, Eskinazi D, Axelrad AA: Circulating erythroid progenitors in polycythemia
                     thropoietin receptor causes inactivation of jak2 and termination of proliferative signals.   vera are hypersensitive to insulin-like growth factor-1 in vitro: Studies in an improved
                     Cell 80(5):729, 1995.                                 serum-free medium. Blood 83(1):99, 1994.
                    102. Arcasoy MO, Harris KW, Forget BG: A human erythropoietin receptor gene mutant     134. Mirza AM, Ezzat S, Axelrad AA: Insulin-like growth factor binding protein-1 is ele-
                     causing familial erythrocytosis is associated with deregulation of the rates of jak2 and   vated in patients with polycythemia vera and stimulates erythroid burst formation in
                     stat5 inactivation. Exp Hematol 27(1):63, 1999.       vitro. Blood 89(6):1862, 1997.
                    103. Marine JC, McKay C, Wang D, et al: Socs3 is essential in the regulation of fetal liver     135. Brox AG, Congote LF, Fafard J, et al: Identification and characterization of an 8-kd
                     erythropoiesis. Cell 98(5):617, 1999.                 peptide stimulating late erythropoiesis. Exp Hematol 17(7):769, 1989.
                    104. Sasaki A, Yasukawa H, Shouda T, et al: Cis3/socs-3 suppresses erythropoietin (EPO)     136. Kent G, Minick OT, Volini FI, et al: Autophagic vacuoles in human red cells. Am J
                     signaling by binding the EPO receptor and jak2. J Biol Chem 275(38):29338, 2000.  Pathol 48(5):831, 1966.
                    105. Prchal JT, Gregg XT: Erythropoiesis. Genetic abnormalities, in Erythropoietins and Ery-    137. Heynen MJ, Tricot G, Verwilghen RL: Autophagy of mitochondria in rat bone marrow
                     thropoiesis, edited by G Molineux, MA Foote, and SG Elliot, p 61. Birkhäuser-Verlag   erythroid cells. Relation to nuclear extrusion. Cell Tissue Res 239(1):235, 1985.
                     AG, Basel, 2009.                                     138. Sandoval H, Thiagarajan P, Dasgupta SK, et al: Essential role for nix in autophagic mat-
                    106. Roberts KG, Morin RD, Zhang J, et al: Genetic alterations activating kinase and cytok-  uration of erythroid cells. Nature 454(7201):232, 2008.
                     ine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell 22(2):153,     139. Kundu  M, Lindsten T, Yang  CY,  et al: Ulk1 plays  a  critical  role  in  the  autophagic
                     2012.                                                 clearance  of  mitochondria  and  ribosomes  during  reticulocyte  maturation.  Blood
                    107. Walrafen P, Verdier F, Kadri Z, et al: Both proteasomes and lysosomes degrade the acti-  112(4):1493, 2008.
                     vated erythropoietin receptor. Blood 105(2):600, 2005.    140. Schweers RL, Zhang J, Randall MS, et al: Nix is required for programmed mitochon-
                    108. Arcasoy MO, Jiang X, Haroon ZA: Expression of erythropoietin receptor splice variants   drial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104(49):19500,
                     in human cancer. Biochem Biophys Res Commun 307(4):999, 2003.  2007.
                    109. Barron C, Migliaccio AR, Migliaccio G, et al: Alternatively spliced mRNAs encoding     141. Hong CI, De NC, Tritsch GL, et al: Synthesis and biological activities of some N4-
                     soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow.   substituted 4-aminopyrazolo(3,4-d)pyrimidines. J Med Chem 19(4):555, 1976.
                     Gene 147(2):263, 1994.                               142. Eshghi S, Vogelezang MG, Hynes RO, et al: Alpha4beta1 integrin and erythropoietin
                    110. Nakamura Y, Nakauchi H: A truncated erythropoietin receptor and cell death: A   mediate temporally distinct steps in erythropoiesis: Integrins in red cell development.
                     reanalysis. Science 264(5158):588, 1994.               J Cell Biol 177(5):871, 2007.
                    111. Prchal JT, Semenza GL, Prchal J, et al: Familial polycythemia. Science 268(5219):1831,     143. Bruchova H, Yoon D, Agarwal AM, et al: Regulated expression of microRNAs in nor-
                     1995.                                                 mal and polycythemia vera erythropoiesis. Exp Hematol 35(11):1657, 2007.
                    112. Noguchi CT, Wang L, Rogers HM, et al: Survival and proliferative roles of erythropoie-    144. Li Y, Bai H, Zhang Z, et al: The up-regulation of mir-199b-5p in erythroid differentia-
                     tin beyond the erythroid lineage. Expert Rev Mol Med 10:e36, 2008.  tion is associated with GATA-1 and NF-E2. Mol Cells 37(3):213, 2014.
                    113. Anagnostou A, Lee ES, Kessimian N, et al: Erythropoietin has a mitogenic and positive     145. Raghavachari N, Liu P, Barb JJ, et al: Integrated analysis of miRNA and mRNA during
                     chemotactic effect on endothelial cells. Proc Natl Acad Sci U S A 87(15):5978, 1990.  differentiation of human cd34+ cells delineates the regulatory roles of microRNA in
                    114. Arcasoy MO: The non-haematopoietic biological effects of erythropoietin. Br J Haema-  hematopoiesis. Exp Hematol 42(1):14, 2014.
                     tol 141(1):14, 2008.                                 146. Lee YT, de Vasconcellos JF, Yuan J, et al: Lin28b-mediated expression of fetal hemoglo-
                    115. Brines M, Cerami A: Discovering erythropoietin’s extra-hematopoietic functions: Biol-  bin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo.
                     ogy and clinical promise. Kidney Int 70(2):246, 2006.  Blood 122(6):1034, 2013.
                    116. Agarwal N, Gordeuk VR, Prchal JT: Are erythropoietin receptors expressed in tumors?     147. Barde I, Rauwel B, Marin-Florez RM, et al: A KRAB/KAP1-miRNA cascade regulates
                     Facts and fiction—More careful studies are needed. J Clin Oncol 25(13):1813; author   erythropoiesis through stage-specific control of mitophagy.  Science 340(6130):350,
                     reply 1815, 2007.                                     2013.
                    117. Hardee ME, Cao Y, Fu P, et al: Erythropoietin blockade inhibits the induction of tumor     148. Pearson TC, Botterill CA, Glass UH, et al: Interpretation of measured red cell mass and
                     angiogenesis and progression. PLoS One 2(6):e549, 2007.  plasma volume in males with elevated venous PCV values. Scand J Haematol 33(1):68,
                    118. Hirota K, Semenza GL: Regulation of angiogenesis by hypoxia-inducible factor 1. Crit   1984.
                     Rev Oncol Hematol 59(1):15, 2006.                    149. Cavill I, Trevett D, Fisher J, et al: The measurement of the total volume of red cells in
                    119. Yoon D, Pastore YD, Divoky V, et al: Hypoxia-inducible factor-1 deficiency results in   man: A non-radioactive approach using biotin. Br J Haematol 70(4):491, 1988.
                     dysregulated erythropoiesis signaling and iron homeostasis in mouse development.      150. Jones J, Mollison PL: A simple and efficient method of labelling red cells with 99mTc for
                     J Biol Chem 281(35):25703, 2006.                      determination of red cell volume. Br J Haematol 38(1):141, 1978.
                    120. Fukuda R, Zhang H, Kim JW, et al: Hif-1 regulates cytochrome oxidase subunits to     151. Pearson TC, Guthrie DL, Simpson J, et al: Interpretation of measured red cell mass and
                     optimize efficiency of respiration in hypoxic cells. Cell 129(1):111, 2007.  plasma volume in adults: Expert panel on radionuclides of the international council for
                    121. Beck I, Ramirez S, Weinmann R, et al: Enhancer element at the 3′-flanking region con-  standardization in haematology. Br J Haematol 89(4):748, 1995.
                     trols transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem     152. Fairbanks VF, Klee GG, Wiseman GA, et al: Measurement of blood volume and red
                     266(24):15563, 1991.                                  cell mass: Re-examination of 51cr and 125i methods. Blood Cells Mol Dis 22(2):169;
                    122. Manalo DJ, Rowan A, Lavoie T, et al: Transcriptional regulation of vascular endothelial   discussion 186a, 1996.
                     cell responses to hypoxia by Hif-1. Blood 105(2):659, 2005.    153. Larson RA: Studies of the body hematocrit phenomenon: Dynamic hematocrit of large
                    123. Maxwell PH, Wiesener MS, Chang GW, et al: The tumour suppressor protein VHL tar-  vessel and initial distribution space of albumin and fibrinogen in the whole body. Scand
                     gets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399(6733):271,   J Clin Lab Invest 22(3):189, 1998.
                     1999.                                                154. Button LN, Gibson JG 2nd, Walter CW: Simultaneous determination of the volume of
                    124. Ivan M, Kondo K, Yang H, et al: Hifalpha targeted for VHL-mediated destruction by   red cells and plasma for survival studies of stored blood. Transfusion 5:143, 1965.
                     proline hydroxylation: Implications for O  sensing. Science 292(5516):464, 2001.    155. Recommended methods for measurement of red-cell and plasma volume: International
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                    125. Jaakkola P, Mole DR, Tian YM, et al: Targeting of HIF-alpha to the von Hippel-Lindau   committee for standardization in haematology. J Nucl Med 21(8):793, 1980.
                     ubiquitylation  complex by O -regulated prolyl  hydroxylation.  Science 292(5516):468,     156. Hillman RS, Finch CA: Erythropoiesis: Normal and abnormal. Semin Hematol 4(4):327,
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                     2001.                                                 1967.






          Kaushansky_chapter 32_p0479-0494.indd   493                                                                   9/17/15   6:11 PM
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