Page 634 - Williams Hematology ( PDFDrive )

608 Part VI: The Erythrocyte Chapter 41: Folate, Cobalamin, and Megaloblastic Anemias 609

15. Kaufman S: The phenylalanine hydroxylating system from mammalian liver. Adv Enzy- 52. Elwood P, Deutsch J, Kolhouse J: The conversion of the human membrane-associ-
mol Relat Areas Mol Biol 35:245–319, 1971. ated folate binding protein (folate receptor) to the soluble folate binding protein by a
16. Kwon N, Nathan C, Stuehr D: Reduced biopterin as a cofactor in the generation of membrane-associated metalloprotease. J Biol Chem 266(4):2346–2353, 1991.
nitrogen oxides by murine macrophages. J Biol Chem 264(34):20496–20501, 1989. 53. Colman N, Herbert V: Total folate binding capacity of normal human plasma, and vari-
17. Banerjee S, Snyder S: Methyltetrahydrofolic acid mediates N- and O-methylation of ations in uremia, cirrhosis, and pregnancy. Blood 48(6):911–921, 1976.
biogenic amines. Science 182(107):74–75, 1973. 54. Waxman S: Folate binding proteins. Br J Haematol 29(1):23–29, 1975.
18. Bird O, McGlohon V, Vaitkus J: Naturally occurring folates in the blood and liver of the 55. Waxman S, Schreiber C: Measurement of serum folate levels and serum folic acid-
rat. Anal Biochem 12(1):18–35, 1965. binding protein by 3H-PGA radioassay. Blood 42(2):281–290, 1973.
19. Shane B: Folylpolyglutamate synthesis and role in the regulation of one-carbon metab- 56. Colman N, Herbert V: Folate-binding proteins. Annu Rev Med 31:433–439, 1980.
olism. Vitam Horm 45:263–335, 1989. 57. Waxman S, Schreiber C: Characteristics of folic acid-binding protein in folate-deficient
20. Pratt R, Cooper B: Folates in plasma and bile of man after feeding folic acid—3H and serum. Blood 42(2):291–301, 1973.
5-formyltetrahydrofolate (folinic acid). J Clin Invest 50(2):455–462, 1971. 58. Rothenberg S: A macromolecular factor in some leukemic cells which binds folic acid.
21. Kisliuk R: Pteroylpolyglutamates. Mol Cell Biochem 39:331–345, 1981. Proc Soc Exp Biol Med 133(2):428–432, 1970.
22. Atkinson I, Garrow T, Brenner A, Shane B: Human cytosolic folylpoly-gamma- 59. Mason J, Selhub J: Folate-binding protein and the absorption of folic acid in the small
glutamate synthase. Methods Enzymol 281:134–140, 1997. intestine of the suckling rat. Am J Clin Nutr 48(3):620–625, 1988.
23. Sussman D, Milman G, Shane B: Characterization of human folylpolyglutamate synthe- 60. Rubinoff M, Abramson R, Schreiber C, Waxman S: Effect of a folate-binding protein on the
tase expressed in Chinese hamster ovary cells. Somat Cell Mol Genet 12(6):531–540, 1986. plasma transport and tissue distribution of folic acid. Acta Haematol 65(3):145–152, 1981.
24. Shane B, Stokstad E: Vitamin B12-folate interrelationships. Annu Rev Nutr 5:115–141, 61. Selhub J, Nakamura S, Carone F: Renal folate absorption and the kidney folate binding
1985. protein. II. Microinfusion studies. Am J Physiol 252(4 Pt 2):F757–F760, 1987.
25. Visentin M, Diop-Bove N, Zhao R, Goldman ID: The intestinal absorption of folates. 62. O’Brien J: Urinary excretion of folic and folinic acids in normal adults. Proc Soc Exp
Annu Rev Physiol 76:251–274, 2014. Biol Med 104:354–355, 1960.
26. Butterworth CJ, Baugh C, Krumdieck C: A study of folate absorption and metabolism 63. Clifford A, Arjomand A, Dueker S, et al: The dynamics of folic acid metabolism in an
in man utilizing carbon-14–labeled polyglutamates synthesized by the solid phase adult given a small tracer dose of 14C-folic acid. Adv Exp Med Biol 445:239–251, 1998.
method. J Clin Invest 48(6):1131–1142, 1969. 64. Green R, Miller JW: Vitamin B12, in Handbook of Vitamins, ed 5. Taylor & Francis,
27. Rosenberg I, Godwin H: The digestion and absorption of dietary folate. Gastroenterol- Boca Raton, FL, 2014.
ogy 60(3):445–463, 1971. 65. Lenhert P, Hodgkin D: Structure of the 5,6-dimethyl-benzimidazolylcobamide coen-
28. Chandler C, Wang T, Halsted C: Pteroylpolyglutamate hydrolase from human jejunal zyme. Nature 192:937–938, 1961.
brush borders. Purification and characterization. J Biol Chem 261(2):928–933, 1986. 66. Lindstrand K: Isolation of methylcobalamin from natural source material. Nature
29. Qiu A, Jansen M, Sakaris A, et al: Identification of an intestinal folate transporter and 204:188–189, 1964.
the molecular basis for hereditary folate malabsorption. Cell 127(5):917–928, 2006. 67. Heyssel R, Bozian R, Darby W, Bell M: Vitamin B12 turnover in man. The assimilation
30. Zhao R, Matherly L, Goldman I: Membrane transporters and folate homeostasis: Intes- of vitamin B12 from natural foodstuff by man and estimates of minimal daily dietary
tinal absorption and transport into systemic compartments and tissues. Expert Rev Mol requirements. Am J Clin Nutr 18(3):176–184, 1966.
Med 11:e4, 2009. 68. Grasbeck R: Calculations on vitamin B12 turnover in man. With a note on the main-
31. Elsenhans B, Ahmad O, Rosenberg I: Isolation and characterization of pteroylpolyglu- tenance treatment in pernicious anemia and the radiation dose received by patients
tamate hydrolase from rat intestinal mucosa. J Biol Chem 259(10):6364–6368, 1984. ingesting radiovitamin B12. Scand J Clin Lab Invest 11:250–258, 1959.
32. Schron C: PH modulation of the kinetics of rabbit jejunal, brush-border folate trans- 69. JM H: Vitamin B12 concentrations in human tissues. In: MPMJA Kawin B, editor.:
port. J Membr Biol 120(2):192–200, 1991. Nature; 1966. p. 1264.
33. Schron C, Washington CJ, Blitzer B: The transmembrane pH gradient drives uphill 70. Nham S, Wilkemeyer M, Ledley F: Structure of the human methylmalonyl-CoA mutase
folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in (MUT) locus. Genomics 8(4):710–716, 1990.
brush border membrane vesicles. J Clin Invest 76(5):2030–2033, 1985. 71. Beck W, Flavin M, Ochoa S: Metabolism of propionic acid in animal tissues. III. Forma-
34. Zimmerman J, Selhub J, Rosenberg I: Role of sodium ion in transport of folic acid in the tion of succinate. J Biol Chem 229(2):997–1010, 1957.
small intestine. Am J Physiol 251(2 Pt 1):G218–G222, 1986. 72. Taylor R, Weissbach H: Enzymic synthesis of methionine: Formation of a radioac-
35. Perry J, Chanarin I: Intestinal absorption of reduced folate compounds in man. Br J tive cobamide enzyme with N5-methyl-14C-tetrahydrofolate. Arch Biochem Biophys
Haematol 18(3):329–339, 1970. 119(1):572–579, 1967.
36. Kanazawa S, Herbert V: Mechanism of enterohepatic circulation of vitamin B12: Move- 73. Zalusky R, Herbert V, Castle W: Cyanocobalamin therapy effect in folic acid deficiency.
ment of vitamin B12 from bile R-binder to intrinsic factor due to the action of pancre- Arch Intern Med 109:545–554, 1962.
atic trypsin. Trans Assoc Am Physicians 96:336–344, 1983. 74. Knowles J, Prankerd T: Abnormal folic acid metabolism in vitamin B12 deficiency. Clin
37. Steinberg S, Campbell C, Hillman R: Kinetics of the normal folate enterohepatic cycle. Sci 22:233–238, 1962.
J Clin Invest 64(1):83–88, 1979. 75. Herbert V, Zalusky R: Interrelations of vitamin B12 and folic acid metabolism: Folic
38. Steinberg S: Mechanisms of folate homeostasis. Am J Physiol 246(4 Pt 1):G319–G324, acid clearance studies. J Clin Invest 41:1263–1276, 1962.
1984. 76. Kano Y, Sakamoto S, Hida K, et al: 5-Methyltetrahydrofolate related enzymes and DNA
39. Johns D, Sperti S, Burgen A: The metabolism of tritiated folic acid in man. J Clin Invest polymerase alpha activities in bone marrow cells from patients with vitamin B12 defi-
40:1684–1695, 1961. cient megaloblastic anemia. Blood 59(4):832–837, 1982.
40. Antony A: The biological chemistry of folate receptors. Blood 79(11):2807–2820, 1992. 77. Waters A, Mollin D: Observations on the metabolism of folic acid in pernicious
41. Weitman S, Weinberg A, Coney L, et al: Cellular localization of the folate receptor: anaemia. Br J Haematol 9:319–327, 1963.
Potential role in drug toxicity and folate homeostasis. Cancer Res 52(23):6708–6711, 78. Jeejeebhoy K, Pathare S, Noronha J: Observations on conjugated and unconjugated
1992. blood folate levels in megaloblastic anemia and the effects of vitamin B12. Blood
42. Luhrs C, Slomiany B: A human membrane-associated folate binding protein is anchored 26:354–359, 1965.
by a glycosyl-phosphatidylinositol tail. J Biol Chem 264(36):21446–21449, 1989. 79. Boss G: Cobalamin inactivation decreases purine and methionine synthesis in cultured
43. Green T, Ford HC: Human placental microvilli contain high-affinity binding sites for lymphoblasts. J Clin Invest 76(1):213–218, 1985.
folate. Biochem J 218(1):75–80, 1984. 80. Finkelstein JD, Martin JJ: Methionine metabolism in mammals. Adaptation to methi-
44. Rothberg K, Ying Y, Kolhouse J, et al: The glycophospholipid-linked folate receptor onine excess. J Biol Chem 261(4):1582–1587, 1986.
internalizes folate without entering the clathrin-coated pit endocytic pathway. J Cell 81. Katzen H, Buchanan J: Enzymatic synthesis of the methyl group of methionine. 8.
Biol 110(3):637–649, 1990. Repression-derepression, purification, and properties of 5,10-methylenetetrahydro-
45. Moestrup SK: New insights into carrier binding and epithelial uptake of the erythropoi- folate reductase from Escherichia coli. J Biol Chem 240:825–835, 1965.
etic nutrients cobalamin and folate. Curr Opin Hematol 13(3):119–123, 2006. 82. Chanarin I, Deacon R, Lumb M, Perry J: Vitamin B12 regulates folate metabolism by
46. Hilton J, Cooper B, Rosenblatt D: Folate polyglutamate synthesis and turnover in cul- the supply of formate. Lancet 2(8193):505–507, 1980.
tured human fibroblasts. J Biol Chem 254(17):8398–8403, 1979. 83. Taheri M, Wickremasinghe R, Jackson B, Hoffbrand A: The effect of folate analogues
47. Zamierowski M, Wagner C: High molecular weight complexes of folic acid in mamma- and vitamin B12 on provision of thymine nucleotides for DNA synthesis in megaloblas-
lian tissues. Biochem Biophys Res Commun 60(1):81–87, 1974. tic anemia. Blood 59(3):634–640, 1982.
48. Duch D, Bowers S, Nichol C: Analysis of folate cofactor levels in tissues using high- 84. Chanarin I, Deacon R, Lumb M, Perry J: Cobalamin and folate: Recent developments.
performance liquid chromatography. Anal Biochem 130(2):385–392, 1983. J Clin Pathol 45(4):277–283, 1992.
49. Cook R, Wagner C: Glycine N-methyltransferase is a folate binding protein of rat liver 85. Hewitt J, Gordon M, Taggart R, et al: Human gastric intrinsic factor: Characterization
cytosol. Proc Natl Acad Sci U S A 81(12):3631–3634, 1984. of cDNA and genomic clones and localization to human chromosome 11. Genomics
50. Rosenblatt D, Cooper B, Lue-Shing S, et al: Folate distribution in cultured human cells. 10(2):432–440, 1991.
Studies on 5,10-CH2-H4PteGlu reductase deficiency. J Clin Invest 63(5):1019–1025, 86. Tang L, Chokshi H, Hu C, et al: The intrinsic factor (IF)-cobalamin receptor binding
1979. site is located in the amino-terminal portion of IF. J Biol Chem 267(32):22982–22986,
51. Stites T, Bailey L, Scott K, et al: Kinetic modeling of folate metabolism through use 1992.
of chronic administration of deuterium-labeled folic acid in men. Am J Clin Nutr 87. Levine JS, Nakane PK, Allen RH: Immunocytochemical localization of human intrinsic
65(1):53–60, 1997. factor: The nonstimulated stomach. Gastroenterology 79(3):493–502, 1980.

Kaushansky_chapter 41_p0583-0616.indd 609 9/17/15 6:24 PM