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66 Part II: The Organization of the Lymphohematopoietic Tissues Chapter 5: Structure of the Marrow and the Hematopoietic Microenvironment 67

TABLE 5–2. Hematopoietic and Microenvironment Adhesion Receptors and Their Ligands
Receptor Subgroups Receptor Cellular Distribution Ligand
INTEGRINS
β subgroup (CD29) CD49d, α β (VLA-4) CD34+ cells (erythroid, and lympho- VCAM-1 (CD106), FN, TSP
1 4 1
myeloid progenitors)
CD49e, α β (VLA-5) CD34+ cells, bone cells FN, laminin
5 1
CD49f, α β (VLA-6) Rare CD34+ cells, monocytes Collagen, laminin
6 1
β subgroup (CD18) CD11a/CD18, α β (LFA-1) CD34+ cell subsets, not on repopulat- ICAM-1, ICAM-2, ICAM-3, DNAM-1
2 L 2
ing stem cells
CD11b/CD18, α β (Mac-1) CD34+ subsets, monocytes ICAM-1, ICAM-2, iC3b, fibrinogen
M 2
β subgroup Vβ (VNR) Megakaryocytes, osteoclast FN, TSP, CD31
3 3
β subgroup α β (LPAM-1) Lymphoid and myeloid progenitor MAdCAM-1, VCAM-1, FN
7 4 7
cells, mature myeloid cells
IMMUNOGLOBULINS
CD31 (PECAM-1) ECs, CD34+ cells, monocytes CD31 homophilic adhesion, α β (VNR), CD38
V 3
CD50 (ICAM-3, ICAM-R) CD34+ cells, monocytes α β (LFA-1), CD11d/CD18 (α β )
L 2 D 2
CD54 (ICAM-1) CD34+ cells, stroma, activated ECs α β (LFA-1), α β (Mac-1)
L 2 M 2
CD58 (LFA-3) CD34+ progenitors, stroma, ECs CD2
CD102 (ICAM-2) ECs, monocytes α β (LFA-1)
L 2
CD106 (VCAM-1) Stroma, activated ECs α β (VLA-4), α β (LPAM-1)
4 1 4 7
CD117 (c-KIT) CD34+ progenitors Membrane KIT ligand
CD242 (ICAM-4) Erythroid cells α -Integrins
V
PRR2 (related to CD155, CD34+, CD33+, CD41+, myelomono- PRR2 homophilic adhesion
the poliovirus receptor) cytic cells, megakaryocytic cells, ECs
LECTINS
x
CD62L (L-selectin) Stroma, CD34+ cells GlyCAM-1, MAdCAM-1, CD162, CD34, sLe ,
PCLP1
CD62E (E-selectin) Activated ECs, (marrow ECs express CD15, sLe , CD162, CLA, sLe x
a
CD62E constitutively)
CD62P (P-selectin) Activated ECs CD162, sLe , CD24 (HSA)
x
SIALOMUCINS
CD34 CD34+ cells, ECs Selectins, other ligands?
CD43 CD34+, monocytes, NK cells CD54 (ICAM-1)
CD162 (PSGL-1) CD34+ cells, ECs CD62L, CD62E, CD62P
CD164 (MGC-24v) CD34+ cells, stroma, monocytes Unknown
CD166 (HCA, ALCAM) CD34+ cells, stromal cells, ECs CD6, CD166
HYALADHERIN
CD44 CD34+ cells, broad distribution Hyaluronan, bFGF, HGF
OTHER
CD38 CD34+ subsets, early T and B cells, CD31, hyaluronan
plasma cells, thymocytes
CD144 (VE-cadherin) CFU-E, stromal cells, ECs E-cadherin
CD157 (BST-1) Stroma, T and B cells, myeloid cells Unknown
ALCAM, activated leukocyte adhesion molecule; bFGF, basic fibroblast growth factor; BST, bone marrow stroma; CD, cluster designation; CFU-E,
colony forming unit–erythroid; CLA, cutaneous lymphocyte antigen; DNAM-1, DNAX accessory Molecule-1; EC, endothelial cell; FN, fibronec-
tin; GlyCAM, glycosylation-dependent cell adhesion molecule; HCA, hematopoietic cell antigen; HGF, hepatocyte growth factor; HSA, heat-
stable antigen; ICAM, intercellular adhesion molecule; iC3b, inactive complement 3b complex; KIT, tyrosine-protein kinase; LFA, lymphocyte
function-associated antigen; LPAM, lymphocyte Peyer patch-specific adhesion molecule; MAdCAM, mucosal addressin cell adhesion molecule;
MGC-24, multiglycosylated core of 24 kDa; NK, natural killer; PCLP, podocalyxin-like protein; PECAM, platelet/endothelial cell adhesion mole-
cule; PRR2, poliovirus receptor-related protein 2; PSGL-P, selectin glycoprotein ligand; sLe, sialyl Lewis; TSP, thrombospondin; VCAM, vascular
cell adhesion molecule; VE, vascular endothelial; VLA, very-late antigen; VNR, vitronectin receptor.

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