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70 Part II: The Organization of the Lymphohematopoietic Tissues Chapter 5: Structure of the Marrow and the Hematopoietic Microenvironment 71

TABLE 5–3. Chemokine Receptors, Interacting Chemokine Ligands, and Cellular Specificity
Receptors Receptor Expression Chemokine Ligands
CXCR1 Neutrophils, monocytes CXCL2 (GROβ), CXCL3 (GROγ), CXCL5 (ENA78), CXCL6
(GCP-2), CXCL8 (IL-8)
CXCR2 Neutrophils, IL-5–primed Eos, monocytes CXCL1,2,3 (GROα/β/γ), CXCL5 (ENA78), CXCL6, CXCL7
(NAP-2), CXCL8(IL-8),
CXCR3 Activated memory and naïve T cells, NK cells; T (preferentially CXCL9 (MIG), CXCL10 (IP-10), CXCL11 (I-TAC)
Th1) cells, B cells
CXCR4 Neutrophils, monocytes, megakaryocytes, CD34+ and pre–B-cell CXCL12 (SDF-1α, SDF-1β)
precursors, resting and activated T cells, DCs
CXCR5 B lymphocytes, T lymphocytes CXCL13 (BCA-1/BLC)
CXCR6 T lymphocytes CXCL16 (SR-PSOX)
CXCR7 B lymphocyte, T lymphocytes, Basos, monocytes, NK cells CXCL11 (I-TAC), CXCL12 (SDF-1α)
CX3CR1 Monocytes, DCs, CD34+ cells, NK cells; in nodal tissues activated CX3CL1 (fractalkine/neurotactin)
T-helper lymphocytes, activated B cells, and follicular DCs
XCR1 Resting T cells, NK cells XCL1 (lymphotactin/SCM-1α/ATAC), XCL2 (SCM-1β)
CCR1 Monocytes, EOS, basophils, activated Neu and T cells, CD34+ CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), CCL8
cells, immature DCs (MCP-2), CCL13 (MCP-4), CCL22 (MDC), CCL23 (MPIF-1)
Monocytes, T cells (not Neu, EOS, or B cells) CCL14 (HCC-1), CCL15 (HCC-2/MIP-5), CCL16 (HCC-4/LEC)
CCR2 Monocytes, basophils, DCs, T cells, activated memory CD4 T CCL2(MCP-1), CCL7 (MCP-3), CCL8 (MCP-2), CCL13
cells, NK cells (MCP-4)
CCR3 Eos, thymocytes, basophils, DCs, activated memory CD4 T cells CCL5 (RANTES), CCL7 (MCP-3), CCL8 (MCP-2), CCL11
(Eotaxin-1), CCL13 (MCP-4), CCL15 (HCC-2/MIP-5), CCL24
(Eotaxin-2/MPIF-2), CCL26 (Eotaxin-3)
CCR4 Activated T cells, immature DCs CCL17 (TARC)
Monocyte-derived DCs, activated NK cells CCL22 (MDC)
Thymocytes (CD3+, CD4+, CD8 ) CCL22 (MDC)
low
CCR5 Monocytes, activated memory CD4 T cells CCL5 (RANTES), CCL8 (MCP-2), CCL13 (MCP-4), CCL14
(HCC-1)
Immature DCs, CD34+ cells, NK cells CCL3 (MIP-1α), CCL4 (MIP-1β)
Human thymocytes CCL4 (MIP-1β)
CCR6 T cells, CD34+–derived dendritic cells CCL20 (MIP-3α/LARC/exodus-1)
CCR7 Activated T (naïve and memory T cells) > B lymphocytes, NK cells CCL19 (MIP-3β/ELC/exodus-3), CCL21 (SLC/exodus-2/
subsets, CD34+ macrophage progenitors, mature DCs 6Ckine) (6Ckine inactive on B cells)
CCR8 Monocytes, T (Th2) cells, NK cells CCL1 (I309), CCL17 (TARC)
CCR9 Thymocytes (CD4+/CD8+, CD4+/CD8–), activated macrophages CCL25 (TECK)
CCR10 Skin-homing memory T cells, CD4/CD8 cells CCL26 (Eotaxin-3), CCL27 (CTACK/ILC/ESkine), CCL28
(MEC)
CCR1 and Neutrophils, monocytes, lymphocytes CCL15 (HCC-2/MIP-5)
CCR3
Not known Resting T cells CCL18 (DC-CK1/PARC)
CCR3/CCR10 Memory lymphocytes, Eos, IgA plasmablasts CCL28 (MEC)
6Ckine, chemokine with 6 cysteines; ATAC, activation-induced, chemokine-related molecule; Baso, basophil; BCA, B-cell attracting chemokine;
BLC, B-cell homing chemokine that activates Burkitt lymphoma receptor 1 (BLR1); CTACK, cutaneous T-cell–attracting chemokine; DC, dendritic
cell; ELC, EBI1-ligand chemokine; ENA, epithelial neutrophil-activating protein; EOS, eosinophil; ESkine, embryonal stem cell chemokine; GCP,
granulocyte chemotactic protein; GRO, growth-related oncogene; HCC, human C-C chemokine; IgA, immunoglobulin A; IL-8 is also chemotactic
for a specific subset of (CD3+, CD8+, CD56+, CD26−) T cells; IP, interferon-inducible protein; I-TAC, interferon-inducible T-cell α chemoattrac-
tant; LARC, liver and activation-regulated chemokine; LEC, liver-expressed chemokine; MCP, monocyte chemoattractant protein; MDC, macro-
phage-derived chemokine, MDC is chemotactic to eosinophils, in a CCR3- and CCR4-independent manner; MEC, mucosae-associated epithelial
chemokine; MIG, monokine induced by interferon-γ; MIP, macrophage inflammatory protein; MPIF, myeloid progenitor inhibitory factor; NAP,
neutrophil-activating peptide; NK, natural killer; PARC, pulmonary and activation-regulated chemokine; RANTES, regulated on activation, nor-
mal T-cell expressed and secreted; SCM, single-C motif; SDF, stromal cell-derived factor; SLC, secondary lymphoid tissue chemokine, also known
as exodus-2 and 6Ckine; SR-PSOX, scavenger receptor for phosphatidylserine and oxidized lipoprotein; TARC, thymus and activation-regulated
chemokine; TECK, thymus-expressed chemokine; Th2, T-helper cell type 2.

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