Page 1189 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 84 Immunoglobulin Therapy: Replacement and Immunomodulation 1153.e1

MULTIPLE-CHOICE QUESTIONS

1. The BEST strategy for dosing of immunoglobulin (Ig) replace- 3. Which of the following receptors during IVIG treatment of
ment therapy in patients with antibody deficiency diseases autoimmune disease is enhanced on effector macrophages?
is by achieving a serum IgG level: A. CD25
A. Of 500 mg/dL B. FcγRI
B. Of 1000 mg/dL C. FcγRIIB
C. Of 200 mg/dL over baseline D. TACI
D. That minimizes the number of infections
4. Which mechanism of action of IVIG is important in the rapid
2. Thromboembolic events associated with intravenous immu- increase in platelet counts in patients with autoimmune
noglobulin (IVIG) therapy in autoimmune diseases is thought thrombocytopenic purpura (ITP)?
to be caused by: A. Saturation of the FcRn receptors
A. Osmolality of the product B. Neutralization of cytokines
B. Sodium content C. Blocking the uptake of complement on platelets
C. Factor XIa D. Blocking the Fc receptors on macrophages
D. IgA in the product