Page 650 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPter 44 Atopic and Contact Dermatitis 624.e1

MUL ti PL e -CHO i C e QU e S ti ONS

1. Immunodeficiencies with eczematous rash that may be 3. Which of the following is a TRUE statement regarding atopic
misdiagnosed as atopic dermatitis include all of the following dermatitis?
EXCEPT: A. Downregulation of a number of antimicrobial peptide
A. Wiskott-Aldrich syndrome (WAS) genes caused by local upregulation of Th2-type cytokines
B. Properdin deficiency could explain the increased susceptibility of patients with
C. Immunodeficiency with mutations in dedicator of cyto- atopic dermatitis (AD) to cutaneous infections.
kinesis 8 (DOCK8) B. Serum levels of thymus and activation-regulated chemokine
D. Immune dysregulation, polyendocrinopathy, enteropathy (TARC) rise with successful treatment.
X-linked (IPEX) syndrome C. Patients whose AD has been in remission for >5 years are
no longer at increased risk for eczema vaccinatum from
2. The TRUE statement regarding filaggrin is:
A. Mutations in the gene encoding filaggrin (FLG) occur only smallpox vaccine.
in patients of European Caucasian descent. D. Langerhans cells are the primary source of antimicrobial
B. Filaggrin is an enzyme that regulates breakdown of the peptides in skin.
epidermal barrier. 4. Which of the following is the MOST common contact
C. T-helper 2 (Th2) cytokines interleukin-4 (IL-4) and IL-13 allergen?
can downregulate FLG gene expression. A. Neomycin
D. Abnormal filaggrin expression in bronchial epithelium B. Nickel
leads to increased risk of asthma. C. Paraphenylenediamine
D. Cocamidopropyl betaine