Page 908 - Clinical Immunology_ Principles and Practice ( PDFDrive )

878 Part SEVEN Organ-Specific Inflammatory Disease

2. Bowcock AM. The genetics of psoriasis and autoimmunity. Annu Rev 18. Cumberbatch M, Singh M, Dearman RJ, et al. Impaired Langerhans cell
Genomics Hum Genet 2005;6:93–122. migration in psoriasis. J Exp Med 2006;203:953–60.
3. Strange A, Capon F, Spencer CC, et al. A genome-wide association study 19. Gudmundsdottir AS, Sigmundsdottir H, Sigurgeirsson B, et al. Is an
identifies new psoriasis susceptibility loci and an interaction between epitope on keratin 17 a major target for autoreactive T lymphocytes in
HLA-C and ERAP1. Nat Genet 2011;42:985–90. psoriasis? Clin Exp Immunol 1999;117:580–6.
4. Tian S, Krueger JG, Li K, et al. Meta-analysis derived (MAD) 20. Prinz JC. Psoriasis vulgaris—a sterile antibacterial skin reaction mediated
transcriptome of psoriasis defines the “core” pathogenesis of disease. by cross-reactive T cells? An immunological view of the pathophysiology
PLoS ONE 2012;7:e44274. of psoriasis. Clin Exp Dermatol 2001;26:326–32.
5. Onoufriadis A, Simpson MA, Pink AE, et al. Mutations in IL36RN/IL1F5 21. Lande R, Botti E, Jandus C, et al. The antimicrobial peptide LL37 is a
are associated with the severe episodic inflammatory skin disease known T-cell autoantigen in psoriasis. Nat Commun 2014;5:5621–36.
as generalized pustular psoriasis. Am J Hum Genet 2011;89:432–7. 22. Albanesi C, Pastore S. Pathobiology of chronic inflammatory skin
6. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med 2009;361: diseases: interplay between keratinocytes and immune cells as a target for
496–509. anti-inflammatory drugs. Curr Drug Metab 2010;11:210–27.
7. Albanesi C, Scarponi C, Bosisio D, et al. Immune functions and 23. Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct
recruitment of plasmacytoid dendritic cells in psoriasis. Autoimmunity human T cell subset involved in epidermal immunity and remodeling.
2010;43:215–19. J Clin Invest 2009;119:3573–85.
8. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in 24. Albanesi C, De Pita O, Girolomoni G. Resident skin cells in psoriasis: a
immunity. Nat Immunol 2004;5:1219–26. special look at the pathogenetic functions of keratinocytes. Clin Dermatol
9. Albanesi C, Scarponi C, Pallotta S, et al. Chemerin expression marks early 2007;25:581–8.
psoriatic skin lesions and correlates with plasmacytoid dendritic cell 25. Di Meglio P, Villanova F, Navarini AA, et al. Targeting CD8(+) T cells
recruitment. J Exp Med 2009;206:249–58. prevents psoriasis development. J Allergy Clin Immunol 2016;138:
10. Nestle FO, Conrad C, Tun-Kyi A, et al. Plasmacytoid predendritic cells 274–6.
initiate psoriasis through interferon-alpha production. J Exp Med 26. Sestito R, Madonna S, Scarponi C, et al. STAT3-dependent effects
2005;202:135–43. of IL-22 in human keratinocytes are counterregulated by sirtuin 1
11. Yao Y, Richman L, Morehouse C, et al. Type I interferon: potential through a direct inhibition of STAT3 acetylation. FASEB J 2011;25:
therapeutic target for psoriasis? PLoS ONE 2008;3:e2737. 916–27.
12. Ketikoglou I, Karatapanis S, Elefsiniotis I, et al. Extensive psoriasis 27. Sano S, Chan KS, Carbajal S, et al. Stat3 links activated keratinocytes and
induced by pegylated interferon alpha-2b treatment for chronic hepatitis immunocytes required for development of psoriasis in a novel transgenic
B. Eur J Dermatol 2005;15:107–9. mouse model. Nat Med 2005;11:43–9.
13. Lande R, Gregorio J, Facchinetti V, et al. Plasmacytoid dendritic cells 28. Bata-Csorgo Z, Hammerberg C, Voorhees JJ, et al. Kinetics and regulation
sense self-DNA coupled with antimicrobial peptide. Nature 2007;449: of human keratinocyte stem cell growth in short-term primary ex vivo
564–9. culture. Cooperative growth factors from psoriatic lesional T lymphocytes
14. Ganguly D, Chamilos G, Lande R, et al. Self-RNA-antimicrobial peptide stimulate proliferation among psoriatic uninvolved, but not normal, stem
complexes activate human dendritic cells through TLR7 e TLR8. J Exp keratinocytes. J Clin Invest 1995;95:317–27.
Med 2009;206:1983–94. 29. Gabay C, Towne JE. Regulation and function of interleukin-36 cytokines
15. Nestle FO, Di Meglio P, Qin JZ, et al. Skin immune sentinels in health in homeostasis and pathological conditions. J Leukoc Biol 2015;97:
and disease. Nat Rev Immunol 2009;9:679–91. 645–52.
16. Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 30. Madonna S, Scarponi C, Sestito R, et al. The IFN-gamma-dependent
cytokine, mediates IL-23-induced dermal inflammation and acanthosis. suppressor of cytokine signaling 1 promoter activity is positively
Nature 2007;445:648–51. regulated by IFN regulatory factor-1 and Sp1 but repressed by growth
17. Costantini C, Calzetti F, Perbellini O, et al. Human neutrophils interact factor independence-1b and Kruppel-like factor-4, and it is dysregulated
with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived in psoriatic keratinocytes. J Immunol 2010;185:2467–81.
IFN-γ : role of CD18, ICAM-1, and ICAM-3. Blood 2011;117:1677–86.