Page 922 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHAPtER 65 Myasthenia Gravis 890.e1

MUL t IPLE-CHOICE QUES t IONS

1. The most frequent pathogenic autoantibodies found in patients 3. A 35-year-old man presented with diplopia, difficulty swal-
with myasthenia gravis (MG) are specific for a conformational lowing, and weakness in his upper and lower extremities. On
epitope on which subunit of the neuromuscular acetylcholine laboratory testing of his serum, he was found to have elevated
receptor? titers of anti–acetylcholine receptor antibodies and antistria-
A. α tional antibodies. He underwent thymectomy, which very
B. β likely showed which of the following pathologies?
C. δ A. Germinal center hyperplasia
D. ε B. Thymic atrophy
C. Cortical thymoma
2. Patients with MG whose serum is positive for anti- muscle-
specific tyrosine kinase (MuSK) antibodies are most resistant D. Medullary lymphoma
to treatment with which one of the following modalities? 4. An inflammatory process in which of the following anatomical
A. Corticosteroid locales is considered to initiate the development of MG?
B. Intravenous immunoglobulin A. Skeletal muscle
C. Plasmapheresis B. Thymic cortex
D. Pyridostigmine bromide C. Cervical lymph node
D. Thymic medulla