Page 136 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

Analysis of hemoglobin ■ Explain the overall impact of intravascular destruction in normal

■ Name at least four laboratory techniques for studying hemoglobin. erythrocyte physiology.

Describe at least four hemoglobin analysis methods and explain the ■ Name the three products of renal processing of filtered

purpose of each procedure. hemoglobin.
Explain the mechanism of intravascular erythrocyte destruction and
Catabolism of erythrocytes the subsequent products of catabolism of hemoglobin.

■ Name the three major components of a disassembled hemoglobin
molecule. NOTE:

Explain the mechanism of extravascular erythrocyte destruction and ■ Indicates MLT and MLS core content

the subsequent products of catabolism and recycling of hemoglobin Indicates MLT (optional) and MLS advanced content

components.

CHARAC ERIS ICS OF HEMOGLOBIN β 2 β 1

I , F x S m -

. H m

m m -

. F ,

m x . ,

m x k m-

x .

Genetic Inheritance of Hemoglobin

N m m A

M ' L I . T

A/A. A m m

m m ; α 2 α 1

x m . M FIGURE 6.1 S m . (R m

m m - P CM. Pathophysiology Concepts o Altered Health States,

m , P , PA: L W m & W k , ,

. D hemoglobinopathies ( m .)

C ) m -

m . m m .
T m -

x m m , -
Chemical Composition and Con guration x . M

of Hemoglobin m

N m m ( m A) (F . . ) - m m m
m m .

m . T - I m , x .
z . E

m (F . . ). N m HEMOGLOBIN FUNC ION
m m

m . T T R , -D , -B
q m k m T m j m m

m m - x . T x f
m . m m -

I m m , m m -
m m , , -

. E , - ( , -DPG , -BPG)
m , m - . T m , -DPG

m . I m ( x m ) x
m m x , f m x. B , , -DPG m