Page 138 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

122 PART 2 ■ Hematopoiesis and Cellular Maturation

Ox m x m m x . O m

- m . I x , m m q m m m

z x x m

tense ( ) structure . I x m , m m .

k , m m A m m m -

relaxed (R) structure . T m x . D

m m m , m m m

R q m - m . T

m x . T m ζ- k-

- x - f m R - m - m m -

- x m . m α- .

Ox m m T m -m m m -

f x m ; k

. T q m ζ- x β- m

x m . T β (H H). C m

x m , k m m x

- m . T m m .

x - T m H P -

m , m (ζ β ) < H P - (ζ γ ) H G - (ζ ε ) < H

. T , -DPG G - (α ε ) < H F < H F (α γ ) < H A (α δ ), ,

x m m , x m m . T m
f , x m . m m -m m -

T m m m x ( m →
m m m x → ).

.
Oxygen Dissociation Curve
Oxygen Alterations Ox m

F m ( m F) f ( x f )

x ( B x . ). T f x H (B ), m ,

- x m .

x x . T x - A H

, x

, -DPG x m m x . T

f m F. x m .

T x f m -
Genetic Hem oglobin Abnorm alities m m .

H m m Ox m x m .

x . T B x m m k

m m m m x m , k H m

, , -DPG . T ,

, m f x . I m-

m , m x m

BOX 6.1 m , -DPG f x .

CARBON DIOXIDE RANSPOR
Adjustments in Hemoglobin-O Af nity
2

T m -
Hemoglobin F Increased O 2 x m

. C x
Altitude Decreased PO 2 m m . T m m

Plasma O 2

Increased O to tissues m .
2

Increased 2,3-DPG I m m m,
x m -
Exercise CO and acid H+ and heat m x , x
2

Produces O from tissues , z z m -
2

, m .