Page 137 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 6 ■ Erythrocytes: Hemoglobin 121

x . C x f m

m

x .

Oxygen Dissociation

T x m

(F . . )

x ( ) -

x (PO ). F m , -

x P . T

P x q

m , x -

FIGURE 6.2 T m m m m ( m ) q

(F ) m j x m ( x m )
+
. A m m m m m - H m . I m , P

, m . . mm H -

H . m . °C. A

x m m m - x f m

’ f x (F . . ). , x f

W m x - .

, . T m I , -DPG, x -

, -DPG m x .

. T

f m x . W x k

, q k ; O Affinity
2
O Release
, x , -DPG; f 80 2

m m x . n

I x , x m m m - o i t a O Affinity
2
, m x m r u t 60 O Release
2
. T a S

m , -DPG, x f b H 2 40

m m . I x , O

, -DPG m , - %

DPG f m 20

m x . “P50” values

20 40 60 80
OXYGEN DISSOCIA ION AND PO torr
2
AL ERA IONS FIGURE 6.4 T x m .

T x % x (P ) x -
T m m m k m . A , x f -
m m , m x

x . W ,

. A H m

f m x . (R m M G,
. Avery’s Neonatology Pathophysiology and Management o the
O O
2
2
Newborn, , P , PA: L W m & W k ,
α α α α , m .) N : T green line m
x . T blue line

H+ ( H), CO , m -

, , -DPG. A
β D β
P m F m x
O 2 β β O 2 G f m . M m -

m x -

f , x

x . T orange line
Oxyhemoglobin Deoxyhemoglobin H+ ( H), CO , m ,

FIGURE 6.3 H m m . , -DPG ( , -BPG).