Page 142 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

126 PART 2 ■ Hematopoiesis and Cellular Maturation

Succinyl CoA + glycine q m

ALA synthetase Delat-amino- . T m m x
levulinic acid k .
Vitamin B 6
Body cells (ΔALA) T ,

ΔALA dehydrase , m . T -

ΔALA m
m m m . I m m -

Porphobilinogen ( m A),

.

Uroporphyrinogen Mitochondrium
Sum m ary of the Assem bly of a Hem oglobin
Molecule

Coproporphyrinogen Protoporphyrin + iron A m m m q .

T :

Protophyrinogen . T α- β- m

mRNA .
. O m
Heme synthetase
, -D
Heme .

FIGURE 6.6 S m . . T α β

.

. A m m x -
q m m αβ m .

. T m m k . . m m m m

T x m m , α β m .

m , z ,

.

NOTE: This is a good time to completely review the Key
Beta Globin Locus Terms in the Glossary and on . It is also a good

T q . T time to complete Review Questions related to the preceding

q , mm , , . T content.

mm m m .
T . E

, m m Beta Globin Gene Clus ter

. T x Chromos ome 11

epsilon gamma delta beta

G A

5’ 3’

Hb F Hb A2 Hb A

Alpha Globin Gene Clus ter

Chromos ome 16

Zeta 2 Zeta 1 Alpha 2 Alpha 1

5’ 3’

FIGURE 6.8 T . T
FIGURE 6.7 B m (β) m m . T mm

H&E . I - m F. T

m. T m “ ” , β, m . T m -
m . ( M. Biopsy Interpretation (α) m m . E

o the Liver, P , PA: L W m & W k , .) α- α- .