Page 186 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

170 PART 2 ■ Hematopoiesis and Cellular Maturation

TABLE 8.2 Contents of Human Neutrophilic Granules

Azurophilic Speci c Gelatinase
Cell Type Primary Granules Secondary Granules Tertiary Granules Secretory Vesicles

Neutrophil Membrane Examples Membrane Examples Membrane Examples Membrane Examples

CD63, CD66c, CD68 CD15, CD66a, CD66b CD11b CD10,

Cytochrome b 558 Cytochrome b 558 Mac-(CD11b),

CD 13, CD16, CD35, CD45

Alkaline phosphatase

Cytochrome b 558

Complement receptor 1

Matrix Examples Matrix Examples Matrix Examples Matrix Examples

Myeloperoxidase Lactoferrin Gelatinase Plasma proteins (including

tetraacetic and albumin)

Lysozymes Lysozyme (muramidase) Lysozymes

Cathepsin G, B, and D Histaminase

Defensins Collagenase

Elastase Gelatinase

Esterase N Heparinases

Bactericidal permeability Histaminase

increasing protein

Vitamin B12–binding protein

Source: Greer JP, et al. Wintrobe’s Clinical Hematology, 12th ed, Philadelphia, PA.: Lippincott-Williams & Wilkins, Table 9.1, 2009;171.

. B m m Production, Function, and Kinetics of

m - Monocytes and Macrophages

, m -

. C m m m m -
m . T

m CFU-GM,

- m -m k (CFU-M)

m m - m -

(CFU-G) . I -

k , m

m x m

. .

Functions of Monocyte Subsets

Monocytes k mm m

mm . M

x m (CAM ),

CD L, m k , CCR CX CR ,

m m m m

mm . M j

, CAM -

FIGURE 8.12 M . (R m A SA, m k

P KB. Anderson’s Atlas o Hematology, P , PA: m
L W m & W k , , m .) mm .