Page 213 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 9 ■ Leukocytes: Lymphocytes and Plasma Cells 197

TABLE 9.4 Lymphocyte Characteristics

Peripheral Blood

Type Function(s) Phenotypic Marker (% of Total)

Helper T (Th) Stimulate B-cell growth and differentiation CD3+, CD4+, CD8− 50–60

cells (humoral immunity)

Macrophage activation by secreted cytokines
(cell-mediated immunity)

Cytotoxic T Lysis of virus-infected cells, tumor cells, and CD3+, CD4−, CD8+ 20–25

(Tc) cells allografts (cell-mediated immunity)

Macrophage activation by secreted cytokines

(cell-mediated immunity)

Natural killer Lysis of virus-infected cells (antibody-dependent Fc receptor for IgG or cells CD16 ~10

(NK) cells cellular cytotoxicity)

B cells Antibody production (humoral immunity) Fc receptors, MHC class II, CD19, CD21 10–15

k B , m m

k . Sm - B . O m

m , CLL. m m

m B m .

I monoclonal antibody MAb
NOTE: This is a good time to complete Review Questions m m m k-

related to the preceding content.
m (F . . ) . I

m , m k m

m , m m ,

CHARAC ERIS ICS OF LYMPHOCY ES k m , m mm -
.

Major Lymphocyte Categories and Functions C m z MA
( m)

S m j m z m k ( m ,

. T cells, B cells, “m k,” ). O ,

natural killer NK lymphocytes ( . ). m k m

Bone Thymus Peripheral
marrow lymphoid
Cortex Medulla organs

Lymphoblast Early Common Mature Mature

thymocyte thymocyte thymocyte T cell

TDT+ CD4 CD4 (T4)

CD10

CD9 CD9 Helper cell
CD10 CD10 CD10 CD4
TDT+ TDT+ CD8 CD8 CD8 (T8)
CD10

Pre-T cell

Suppressor cell

FIGURE 9.12 Ex m m k - m . - m ( -
) m m , mm m , m m . S m -

m m m k . CD ( ) CD ( ) m k m k m .