Page 217 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 9 ■ Leukocytes: Lymphocytes and Plasma Cells 201

C mm -

TABLE 9.8 Characteristics of CD4 T Cells B ( . ). T -B m k

: m x ( D ) m k-

Representative : CD , CD , mm (CALLA

Subset Major Activities Cytokines Produced [CD ]).
T q -B

Th1 Autoimmunity intracel- IFN-α, IL-2, IL-10 mm m.

lular pathogen defense Imm m

Th2 Extracellular parasites IL-4, IL-5, IL-10, IL-13, . T (µ) I M z
defense active in IL-25 z -B . O m k D ,

asthma and allergic CD , CD , CALLA, HLA-DR. P -BCR
reactions k m -B

k m .
Th17 Autoimmunity extra- IL-10, IL-17a, IL-17f,

cellular bacteria IL-21, IL-22 I x m , mm B

defense fungi defense m ( I ) mm ( I )
m m m
iTreg Regulation of immune IL-10, IL-35, TGFβ I M. T - I M m

responses immune I M m m m .

tolerance lymphocyte R m m F ( m ,

homeostasis
c z ) mm (I G)

IFN-α, interferon gamma; TGFβ, transforming growth factor beta. . A

m , m .

T m B mm -

, I M I D. W , B

T z x ,

m , x - m ( - ). S m

. S . mm m m m m

m j CD . T m j mm m B- m ;

CD + m - - ,

. m .

B Cells Functional Testing of Lymphocytes

Af m - m m m -

f - . S m (cytokines) m -
m , m , m , ,

m I B - - mm . Im k

f . I :

m B k z , I V . Migration inhibition factor (MIF): m m -

m x m .

M I V m m . . Interleukin 2 IL 2 cell growth actor : m j

B m f - m -

. . Chemotactic actor:

A - B mm

. Interleukin 1 IL 1 : m -

■ P - B
m CD + CD + . I MHC II k-

, m x LYMPHOCY ES, B LYMPHOCY ES, AND

mm z . PLASMA CELL KINE ICS

■ P k m k
mm H – B- -

m mm . q -

■ A mm m B- - z B m m .
m T m m

CD + CD + , , , B

x - m . .