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198            PART 2  ■  Hematopoiesis and Cellular Maturation




                           m,                      m      m                        m

                                   . I                m,                m   k                    -                               BOX  9.1



                            ,

               MA   ,                  m  m             cluster of differentiation (CD).                                      Interleukin 21 (IL-21) Regulation of B-Cell

               M                                                                                                              Function

               m                                                                                  m  m-                       ■ E                                                         CD    L,  BCR

                                               .  T               q                                                                           m

                                          (      C               ).                                                           ■ I              x                             m   k     A/CDA, XBP-  ,



               T Lym phocytes                                                                                                         .
                                                                                                                              ■ I            CSR                           I  G   , I  G  ,        I  A
                                                                    mm                      (      -                          ■ P   m                                  B                     m         m

               m              mm        )                                                                                                             I  M, I  G, I  ,        I  E

                                                                                           B    m      -                      ■ S         z           IL-        CSR     I  G

                      .  S        z             m                                m                                                    I  E

                                   m                                                                       ,                  ■ S                                m            m                                -

                            ,           ,            z     . T                                                                                    m

                              j                                               .                                               ■ G                                            m                    m          ,


                                                                                                                                    .  ., m       m
               B Lym phocytes
                                                                                                                              ■ R  q                           S  A                            m
               T            m                                                                  B    m-

                           . T                                              m                   B

                                              m             x                 mm               -

                    (I  )                                      ,

                                 B                                                        k        ,                                                   mm                         ( mm                    ).

                                        m         B-                      . D         m              ,                     S  m                B                                                      m     x

               B                                                                       ,                 -                            ,                q                               m       m

                       z                            m   k                                           I                      (                       z  ,            ,                                                ),

                         x            .                                                                                         ,        B        . B    m

                    T                                                              B-                  :                                                                                . T

               B-      , CD    , B          , m            z       B        ,        B          .                                               j                                                 m

               N          I  M (  I  M)                      B                        mm                                         B       .

                q           m                                            . Imm       mm  -

                               (I  )                                           -                        -                  Natural Killer Lym phocytes

                                     .                                                                                     NK    m                   NK                                   m

                    B                                                            :                                                        .          ,                                    z                 q

                                                                                                                            m                              mm              m

                .  CD                          m                        m  m       B        ,                                                  m                      .
                          m                         ,          x             m  m       B                                       NK         ,                    m  CD    +      m                             -

                                                                   m     ,                                                             ,                                   mm              m. U    k

                            mm                                         m                          .

                .  B                            z            -                                                             B    m                                                        -              mm
                                                                                                                                  m, NK                                      -                          mm  -
                .  B            MZ                              z              -                                                                         m              m                         .

                                   .
                                                                                                                                NK                  m      B                                               :
                .  R              B        ,                  m                            ,                                                                                                      m     x

                             m            IL-                                     m          .

                .  A    -                 B         (ABC )                                                                                            m
                                                                                                                              x      . NK                                                              -        ,
                     B-                                                     . T                    k                                          m ,                  k     m                                     m

                     CD            CD       x            . T               CD    /                                                                           .

                     m   k              x             B        . F                 , ABC                                        O        W       -                                           m     ,  NK

                                                                                                        .
                                                                                                                                  m                           m              m

                    C           ,         m                         k                                                                     m                                            z

                                       m     B-                        IL-     (      B  x   .  ).                                                m.

               B                                m                                                                               T                                     m     NK                            -

                  m        (              )                .  P                         B                                                                                              .           mm            -

                          m         mm                                   m                                                                                                 NK         ,  CD

                          m                      m          ,                q                                             CD           m ,                                                     . CD                 m
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