Page 216 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

200 PART 2 ■ Hematopoiesis and Cellular Maturation

m , CD m- m z m m

, m : mm . B ,

m m ,
■ P m - - k

■ m ( ), B , .

T m B m -

M m x q -

: m m m - - m . L m

m m . m m q -

T x . A - m

m . T m - x B ,

, m - x m -

, . T z . L m

m k m m . m , m ,

I m , m k , m , m

m m m -

m . V x m .

m m k . T

m m m k T Lymphocytes

m m , -

m ( . ., q mm - m q m

m [AIDS]), k m ( C ), m . B m m -

m mm . m . S m
q m k , CCR CCR . T m

N
Major Lymphocyte Membrane - m – m .

Characteristics and Development M ( F . . ) z

T m m m m m m k . E B

m . T m- z m D , CD , CD ,

( x m m m k ) m . H , m k ,

. . C mm CD CD , mm

. O m k q m -

. S m m k m .
Cell Differentiation Antigen
TABLE 9.7 T m k m , CD
Distribution
CD , m k m k m m

Cell Differentiation Antigen .

Antigen Distribution Cluster Designation I , CD m
: T T . T m

CD2 78%–88% T cells, NK cells k -

CD3 68%–82% mature T cells . T mm -

m m ; T mm
CD4 35%–55% mature T cells, monocytes
m x , m -
CD5 65%–79% T cells, B-cell subset . A m T m

CD7 75% T cells and NK cells - mm ; T

CD8 20%–36% mature T cells m mm .

, CD -
CD10 90% of common ALLs, granulocytes,

(CALLA) immature B cells m x : T , T , T , -
( ) .
CD19 5%–15% B cells CD mm . T

CD20 5%–15% B cells CD

CD21 5%–15% mature B cells, dendritic cells
■ H B m m k
CD22 5%–15% B cells ■ I m m

CD34 Bone marrow progenitor cells, TdT+ cells,

some acute leukemias ■ R , ,
mm
Adapted with permission from Turgeon M. Immunology and Serology in

Laboratory Medicine, 4th ed, St. Louis, MO: Mosby, 2006:63. ■ P k m k mm