Page 250 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

234 PART 3 ■ Hematology Laboratory Assessments

m m m

: TABLE 11.2 Basic Assessment of Anemias

■ A m m

■ C x Indices Supplementary

■ H m Results RBC Indices Testing

■ A m m
,
Normal MCV MCHC Serum iron

Other Measurement or Calculations Total iron-binding
capacity (TIBC)
I m m m , k

m (m m ), , Ferritin

,
m m - Decreased MCV MCHC Serum iron
m . T m : Total iron-binding

capacity (TIBC)
. R ( . )

. T m Ferritin

. R (RDW) m Increased MCV Serum vitamin B 12

x (RCMI) Serum folic acid

. P m

. R - m MCV mean corpuscular volume, adult reference range 80 to 96 fL;

. B m x m MCHC mean corpuscular hemoglobin concentration, adult reference
range 33% to 36%; MCH mean corpuscular hemoglobin, adult reference

range 27.5 to 33.2 pg.
Indications for Bone Marrow Examination

A q , , m x m

m x m ( C ) m m m m . T

m m k , m m m x m :

m : (M:E) . O m -

m m . ■ M m m

B mm m x m , P m m -

x ( F . . ). I m .

Clinical s igns and s ymptoms : weaknes s , fatigue, and pallor

Complete blood count with differential, RBC indices and morphology, reticulocyte count

Hemoglobin decreas ed: males <13.0 g/dL, females <12 g/dL

Clas s ification by RBC indices

Low MCV, MCHC Normal MCV, MCHC High MCV
Microcytic, hypochromic Normocytic, normochromic Macrocytic

Typical of maturation defects Typical of hypoproliferation Typical of maturation defect

Iron deficiency anemia (some) Bone marrow disorder Vitamin B deficiency
12
Thalassemia Iron deficiency anemia (some) Folate deficiency
Sideroblastic anemia Anemia of chronic disorders Excessive alcohol ingestion
Autoimmune disease Hypothyroidism

FIGURE 11.4 A m m .